Geraldine Guasch, PhD
Appointment
Assistant Professor of Pediatrics, University of Cincinnati College of Medicine
Email
geraldine.guasch@cchmc.org
Phone
513-803-2607
Fax
513-636-4317
Credentials
Postdoctoral research fellow: The Rockefeller University, New York, NY, 2002-2008
Topic: Isolation of hair follicle stem cells and characterization of their molecular signature. Analysis the roles of TGFβ-mediated signaling pathways in skin stem cell biology.
PhD: University of Aix-Marseille, France, Immunology/Oncology, 2002
Topic: Identification of genes involved in chromosomal translocations associated with stem cell myeloproliferative disorder. Characterization of the molecular mechanism that induces the leukaemic phenotype in the haematopoietic cells of the patients. Identification of putative target for therapy of this myeloproliferative disease.
BS: University Montpellier II, France, Biochemistry, 1997
Awards and Honors
Trustee Grant Award, Cincinnati Children’s Hospital Research Medical Center, 2009
SID Eugene M. Farber Endowment Travel Awards, 2009
Human Frontier Science Program Organization, 2002-2005
National Award Best PhD in Immunology-Oncology of the Year, 2002
French Fellowship ‘Foundation for Medical Research’’, 2002
French Fellowship ‘’National league against cancer’’, 2001-2002
French Ministry of Research Fellowship, 1998-2001
Research
In our laboratory we are using the mouse as a model system to investigate the role of stem cells in tumor development. Our long-term goal is to understand whether skin cancers arise from stem cells and whether tumors maintain stem cells, using a combination of genetics and biochemical studies.
Visit the Guasch Lab web site.
Publications, Most Recent
Guasch G, Schober M, Pasolli A, Conn E, Polak L, Fuchs E. Loss of TGFβ signalling destabilizes homeostasis and promotes squamous cell carcinomas in stratified epithelia. Cancer Cell 2007;12:313-27.
*Li J, *Greco V, *Guasch G, Fuchs E, Mombaert P. Mice cloned from skin cells. Proc Natl Acad Sci USA 2007;104: 2738-43. (* contributed equally to this work).
Lowry W, Blanpain C, Nowak J, Guasch G, Lewis L, Fuchs E. Defining the impact of β-catenin/Tcf transactivation on epithelial stem cells. Genes & Dev 2005;13:1596-611.
Guasch G, Fuchs E. Mice in the world of stem cell biology. Nature Genetics 2005;37(11):1201-6. [review]
Tumbar T, Guasch G, Greco V, Blanpain C, Lowry W, Rendl M, Fuchs E. Defining the epithelial stem cell niche in skin. Science 2004;303:359-63.
Fuchs E, Tumbar T, Guasch G. Socializing with the neighbors: stem cells and their niche. Cell 2004;116: 769-78. [review]
Guasch G, Delaval B, Arnoulet C, Xie MJ, Xerri L, Sainty D, Birnbaum D, Pebusque MJ. FOP-FGFR1 tyrosine kinase, the product of a t(6;8) translocation, induces a fatal myeloproliferative disease in mice. Blood 2004;103:309-12.
Guasch G, Popovici C, Chaffanet M, Mugneret F, Pontarotti P, Birnbaum D., Pébusque M.J. Endogenous retroviral sequence is fused to FGFR1 kinase in the 8p12 stem cell myeloproliferative disorder with t(8;19)(p12;q13.3). Blood 2003;101:286-8.
Guasch G, Ollendorff V, Borg JP, Birnbaum D, Pébusque M-J. 8p12 stem cell myeloproliferative disorder: the FOP-Fibroblast growth factor receptor 1 fusion protein of the t(6;8) translocation induces cell survival mediated by mitogen-activated protein kinase and phosphatidylinositol 3-Kinase/AKT/mTOR pathways. Mol Cell Biol 2001;21:8129-42.
Professional Organization Memberships
Contact Us
The Guasch laboratory is part of the Division of Developmental Biology at Cincinnati Children's Research Foundation and the University of Cincinnati School of Medicine. Our lab is located in Location S (Research Foundation Building), Room S3.350.
Graduate students are welcome and encouraged to apply. For more information, please contact Geraldine Guasch at 513-803-2607.
