Developmental Biology

Nadean L. Brown, PhD

Appointment

Assistant Professor

Email

nadean.brown@cchmc.org

Phone

513-636-1963

Fax

513-636-4317

Position History

PhD, Cellular and Molecular Biology, University of Wisconsin, Madison, WI 1994

Postdoctoral Fellowship, Department of Biology, University of Michigan 1995-1996

Postdoctoral Fellowship, Departments of Human Genetics and Internal Medicine, 1996-1999

Assistant Professor, Division of Developmental Systems Biology, Department of Pediatrics, Northwestern University Medical School, Chicago, IL, 2000-2002

Research

Visit the Brown Lab Site.

Research Grants and Contracts

NIH EY18097 4/2008-4/2012 - Cell-Cell Signaling during Mammalian Eye Formation

Grant-In-Aid from The Glaucoma Foundation 1/2007-12/2007 In Vivo Investigation of Optic Nerve Formation and Connectivity within the Mouse Brain

NIH EY13612 8/2004-8/2008 - Investigation of Mammalian Retinal Neuron Development

NIH EY13612 8/2001-2004 - Investigation of Mammalian Retinal Neuron Development

Publications, Most Recent

Nadean Brown's publications as listed by PubMed

Rowan S, Conley K, Le TT, Donner AL, Maas RL, Brown, NL. Notch signaling is required for mouse lens growth and differentiation.Developmental Biology Submitted.

Blackburn DC*, Conley K*, Platchetzki D, Kempler K, Battelle BA, Brown NL. Isolation and expression of Pax6 and atonal homologues in the American Horseshoe Crab, Limulus polyphemus. (*Co-First Authors) Developmental Dynamics 2008 In Revision.

Riesenberg AN, Le TT, Willardson MI, Blackburn DC, Vetter ML, Brown NL. Initiation of mouse retinal neurogenesis via Pax6 regulation of Math5 expression.Developmental Biology 2008 In Revision.

Willardson MI, Suli A, Marsh-Armstrong N, Chen CB, Moore KB, Brown NL, Vetter ML. Temporal regulation of Ath5 gene expression during eye development.Developmental Biology 2008 In Revision.

Hufnagel R, Riesenberg AN, Saul SM, Brown NL. Conserved regulation between Math5 and Math1 as revealed by Math5-GFP transgenes.Molecular and Cellular Neuroscience 2007; 36: 435-488.

Le TT, Wroblewski E, Patel S, Riesenberg AN, Brown NL. Math5 is required for both early retinal neuron determination and cell cycle progression.Developmental Biology 2006; 295:764-778.

Harzsch S., Vilpoux SK, Blackburn DC, Platchetzki D, Brown NL, Melzer R, Battelle BA. Evolution of arthropod visual systems: development of the eyes and central visual pathway of the horseshoe crab Limulus polyphemus.Developmental Dynamics 2006; 235:2641-2655.

Hutchenson D, Hanson M, Moore KB, Le TT, Brown NL, Vetter ML. bHLH-dependent and -independent modes of Ath5 gene regulation during retinal development.Development 2005;132:829-839.

Philips GT, Stair CN, Lee HY, Wroblewski E, Berberoglu MA, Brown NL, Mastick GS. Precocious retinal neurons: Pax6 regulates the timing of differentiation and the determination of cell type.Developmental Biology 2005; 279:308-321.

Brzezinski J*, Brown NL*, Tanikawa A, Bush RA, Sieving P, Vittaterna MH, Takahashi J, Glaser T. Abnormalities in circadian behavior and retinal electrophysiology in Math5 mutant mice.Invest Ophth Vis Sci 2005; 46:2540-2551. *Co-First Authors

Lee HY, Wroblewski E, Philips GT, Stair CN, Conley K, Reedy M, Mastick GS, Brown NL. Multiple requirements for Hes1 during early eye formation.Developmental Biology 2005; 284:464-478.

Professional Organization Memberships

Teaching

I contribute one lecture on evolution and development to the Intro to Devlopmental Biology course (MDB program), and one lecture for each course on vertebrate eye development in the Advanced Developmental Biology course (MDB program) and Neurodevelopment and Plasticity Course (Neuroscience Program).