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Developmental Biology

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Noah F. Shroyer, PhD

Title

Assistant Professor

Email

noah.shroyer@cchmc.org

Phone

513-636-0129

Fax

513-636-5581

Credentials

BS: Microbiology and Biochemistry, Louisiana State University, Baton Rouge, LA, 1995.

PhD: Cell and Molecular Biology, Baylor College of Medicine, Houston, TX, 2001.

Postdoctoral: Molecular and Human Genetics, Baylor Colege of Medicine, Houston, TX, 2001-2005.

Position History

Assistant Professor, Department of Pediatrics, Baylor College of Medicine, 2005-2006.

Awards and Honors

NEI predoctoral training grant, 1996-2001.

Claude W. Smith Fellowship Award, 1999.

Best Oral Presentation, Cell and Molecular Biology Program, 2000.

NIDDK postdoctoral training grant, 2002-2003.

NRSA individual postdoctoral fellowship, 2003.

Texas Gulf Coast Digestive Diseases Center Pilot / Feasibility award, 2005-2006.

Poster of Distinction, Department of Pediatrics Fellows' Day, 2005.

Research Scholars Award, AGA / Foundation for Digestive Health and Nutrition, 2005-2008.

Travel Award, FASEB Conference "Innovations in GI Research and Therapy", 2005.

NIDDK Mentored Research Scientist Development Award (K01), 2005-2009.

Research

The Shroyer laboratory seeks to understand the molecular mechanisms of intestinal epithelial development, and how these pathways are impacted during diseases such as inflammatory bowel disease and colon cancer.

Three current aims include:

  1. Characterizing the molecular pathway for intestinal epithelial differentiation. We are currently studying the targets of the transctription factors Math1 and Gfi1.
  2. Identify the role of the intestinal secretory cells in inflammatory bowel disease. We are manipulating the number of secretory cell types in the intestine to understand their contribution to inflammation and injury repair.
  3. Understand the role for Math1 and Gfi1 in proliferative homeostasis and cancer of the intestine and colon. Using genetically modified mice, we will determine the role for these transcription factors in regulating proliferation and tumorigenesis.

Research Grants and Contracts

American Gastroenterological Association Foundation for Digestive Health and Nutrition; Intestinal secretory lineage differentiation and function; 07/2005-06/2008; Primary Investigator.

National Institutes of Health, National Institute of Diabetes and Digestive and Kidney Diseases; Intestinal secretory lineage development and function; 09/2005-08/2009; Primary Investigator.

Publications, Most Recent

Yatsenko, A.Y.; Shroyer, N.F.; Lewis, R.A.; Lupski, J.R.: An ABCA4 genomic deletion in patients with Stargardt disease.Human Mutation, 2003; 21:636-644.

Shroyer, N.F.; Wallis Shultz, D.; Venken, K.J.T.; Bellen, H.J.; Zoghbi, H.Y.: Gfi1 functions downstream of Math1 to control intestinal secretory cell subtype allocation and differentiation.Genes and Development, 2005; 19:2412-7.

Professional Organization Memberships

American Gastroenterological Association

Gastroenterology Research Group

Presentations, Most Recent

Helmrath, M.; Shroyer, N.F.; Zoghbi, H.Y.; Henning, S.J.: The role of Math1 (Mouse Atonal Homolog 1) dependent intestinal secretory cells in adaptation following a massive small bowel resection. Presented at the 89th Clinical Congress of the American College of Surgeons Surgical Forum; 2003; Chicago, IL.

Shroyer, N.F.; Zoghbi, H.Y.: Microarray-based expression profiling of embryonic intestine from Math1 null mice. Presented at Digestive Diseases Weak; 2004; New Orleans, LA.

Shroyer, N.F.; Shultz, D.W.; Venken, K.; Bellen, H.; Zoghbi, H.Y.: Intestinal differentiation and function. Presented at the 21st Interdisciplinary Neonatal Nutrition and Gastroenterology Symposium; 2004; Ft. Lauderdale, FL.

Shroyer, N.F.; Shultz, D.W.; Venken, K.; Bellen, H.; Zoghbi, H.Y.: Gfi1 Functions Downstream Of Math1 To Control Intestinal Secretory Cell Differentiation. Presented at Digestive Diseases Weak; 2005; Chicago, IL.

Shroyer, N.F.; Shultz, D.W.; Venken, K.; Bellen, H.; Zoghbi, H.Y.: Gfi1 Functions Downstream Of Math1 To Control Intestinal Secretory Cell Differentiation. Presented at the FASEB Summer Research Conference "Gastrointestinal Tract XI: Innovations in GI Research and Therapy."; 2005; Snowmass Village, CO.

Shroyer, N.F.; Wang, V.Y-C.; Zoghbi, H.Y.: Intestine specific deletion of Math1 reveals its roles in epithelial cell fate determination and homeostasis. Presented at Digestive Disease Week; 2006; Los Angeles, CA.

Shroyer, N.F.; Helmrath, M.A.; Wang, V.Y-C.; Henning, S.J.; Zoghbi, H.Y.: Adaptation following massive small bowel resection requires Math1 dependent intestinal secretory lineages. Presented at Digestive Disease Week; 2006; Los Angeles, CA.

Related Areas

This person works in these other areas at Cincinnati Children's Hospital Medical Center: