Rashmi S. Hegde, PhD
Title
Professor, Cincininnati Children's Hospital Medical Center
Appointment
Professor, University of Cincinnati College of Medicine
Email
rashmi.hegde@chmcc.org
Phone
513-636-5947
Fax
513-636-6772
Bio
Rashmi Hegde received her PhD in Medicinal Chemistry from the University of Pittsburgh in 1989. She received post-doctoral training in the Department of Molecular Bioophysics and Biochemistry at Yale University, where she was a fellow of the National Cancer Center. She was appointed Assistant Professor of Biochemistry at New York University School of Medicine and the Skirball Institute of Biomolecular Medicine in 1994. She is presently a full Professor in the Department of Pediatrics, University of Cincinnati College of Medicine and the Division of Developmental Biology at Childrens Hospital Research Foundation.
Credentials
PhD: University of Pittsburgh, Pittsburgh, PA, 1989
Post-doctoral Fellowship: Yale University, 1989-1994
Assistant Professor: New York University School of Medicine, Skirball Institute, 1994-2000
Associate Professor: (2001 - 2007) Cincinnati Children's Hospital Medical Center
Professor (2008 - present): Cincinnati Children's Hospital Medical Center
Awards and Honors
1993 National Cancer Center post-doctoral fellowship
1994 American Cancer Society Institutional Research Grant
1995 Whitehead Presidential Research Fellowship for Junior Investigators
1999 Dean's Recognition Citation for Excellence in Medical Education, NYU Med. Center
Research
Visit the Hegde Lab Site.
Molecular mechanisms underlying early stages in embryonic organ development, molecular basis of developmental defects and cancer, protein-DNA interactions, X-ray crystallography
Research Grants and Contracts
Mechanism of Action of Retinal Determination Proteins
Type: RO1 (2004 - 2010) EY014648
Role: PI
Eyes Absent Phosphatase inhibitors in eye diseases
Type: R21 (2009 - 2011) EY019125
Role: PI
CRIM1-ß catenin – cadherin interactions in eye development and disease
Type: R01 (2009-2011) EY019377
Role: PI
Publications, Most Recent
Rashmi Hegde's publications as listed by PubMed
Miller S.J., Lan Z.D., Hardiman A., Wu J., Kordich J.J., Patmore D.M., Hegde R.S., Cripe T.P., Cancelas J.A., Collins M.H., Ratner N. (2009) “Inhibition of Eyes Absent Homolog 4 expression induces malignant peripheral nerve sheath tumor necrosis.” Oncogene, Nov. 9 Epub ahead of print
Trompette A., Divanovic S., Visintin A., Madan R., Blanchard C., Hegde R.S., Wills-Karp M., Gioannini T.L., Weiss J.P., Karp C.L.(2009) “Allerginictiy resulting from functional mimicry of a Toll-like receptor complex protein.” Nature, 457(7229):585-8.
Tan M., Xia M., Chen Y., Bu W., Hegde R.S. Meller J., Li X., Jiang X. (2009) “Conservation of carbohydrate binding interfaces – Evidence of human HBGA selection in Norovirus evolution.” PLoS ONE, 4(4):e5058
Morrelae R., Fernandez-Fuentes N., Chen Z., Hegde R.S., Butsch-Kovacis M., Wells S.I., (2009) “Insights from transcriptional profiling of human papillomavirus infection and associated carcinogenesis.” review in Molecular Biology of Tumor Virus Gene Products169-196 (Publisher: Research Signpost, Editor: Kenichi Yoshida)
Blakaj D.M., Fernandez-Fuentes N., Chen Z., Hegde R.S., Fiser A., Burk R.D., Brenowitz M. (2009) “Evolutionary, structural and electrostatic relationships among the papillomavirus E2 protein DNA binding domains.” Frontiers in Bioscience, 14:900-17
Bu W., Mamedova A., Xia M., Tan M., Jiang J., Hegde R.S. (2008) “Structural basis for the receptor binding specificity of the Norwalk virus.” J. Virology 82(11):5340-7
Hu S.H., Mamedova A., Hegde R.S. (2008) “DNA binding and regulation mechanisms of the SIX family of retinal determination proteins.” Biochemistry, 47:3586-3594
Liu, Y., Henry, G.D., Hegde, R.S., Baleja J.D. (2007) “Solution structure of the hDlg/SAP97 PDZ2 domain and its mechanism of interaction with HPV-18 papillomavirus E6 protein.” Biochemistry 46(38):10864-74
Hegde R.S. (2006) “Papillomavirus proteins and their potential as drug design targets.” Future Virology, 1(6):795-810
Rayapureddi J.P. and Hegde R.S. (2006) “Branchio-oto-renal syndrome associated mutations in Eyes Absent 1 result in loss of phosphatase activity.” FEBS Letters 580(16):3853-3859
Liou B., Kazmierczek A., Zhang M., Scott C.R., Hegde R.S., Grabowski G. (2006) “Analyses of variant Acid -Glucosidases: Effects of Gaucher disease mutations.” Journal of Biological Chemistry 281(7):4242-53
Blakaj D.M., Kattamuri C., Khrapunov S., Hegde R.S., Brenowitz M. (2006) “Indirect readout of DNA sequence by papillomavirus E2 proteins depends upon cation uptake.” Journal of Molecular Biology 358(1):224-40
Seufert D.W., Hegde R.S., Nekkalapudi S., Kelly L.E., El-Hodiri H.M. (2005) “Expression of a novel Ski-like gene in Xenopus Development.” Gene Expression Patterns 6(1):22-8
Rayapureddi J.P., Kattamuri C., Chan F.H., Hegde R.S. (2005) “Characterization of a plant, tyrosine-specific phosphatase of the aspartyl class.” Biochemistry 44(2):751-8
Teaching
Join members of the Visual Systems Research Group for the The Great Lakes and Abrahamson Pediatric Eye Institute Vision Research Conference, November 11-12, 2005. Learn more about this conference here.
Special Interests
Research in the Hegde Laboratory is aimed at understanding the structural basis for specificity in macromolecular interactions. Currently the two main areas of interest in the laboratory are:
- proteins involved in early vertebrate development
- proteins involved in the life- and infection-cycles of the cancer-associated papillomaviruses.
