Developmental Biology

Christopher Wylie, PhD

Title

William Schubert Professor of Pediatrics

Appointment

Professor of Pediatrics, and Director of the Division of Developmental Biology

Email

christopher.wylie@cchmc.org

Phone

513-636-2090

Fax

513-636-4317

Bio

After spending his early years in Kenya, Chris Wylie moved to England. He attended University College Hospital Medical School, where he gained a B.Sc. in Anatomy, and a PhD in Developmental Biology. He held faculty positions at University College London, and St. George's Hospital Medical School before taking the Frederick James Quick Chair of Biology at Cambridge University in 1989. In 1994, he accepted the Martin Lenz Harrison Chair of Development and Genetics at the University of Minnesota School of Medicine in 1994, where he led the University of Minnesota Developmental Biology Center. In 2000, he moved to the Cincinnati Children's Hospital to become the Director of the Developmental Biology Division, and the first William K. Schubert Professor in the Department of Pediatrics. He was the founding Editor of the International journal "Development", and has served as President of the Society for Developmental Biology.

Awards and Honors

First Class Honours in the University of London B.Sc. examination
Member of the UK Medical Research Council Cell Biology Grants Committee (Study Section) 1985-89. -Member of the Medical Research Council Training Awards Panel 1989-93
External Examiner for the Universities of Singapore, Cambridge, London, Glasgow, Oxford
Member of the Wellcome Trust Equipment Committee (a study section for major grant applications for equipment and rebuilding) 1993-4
University Grants Committee Medical Sciences Panel (a government committtee setup to rank medical research in British Medical Schools, for funding purposes), 1992 and 2001
Fellowship of Darwin College Cambridge, 1989-94
Numerous site visit committees for UK Medical Research council and Science Research Council
NIH study section CDF5 (HED2) 1996- 2000
Chair, Burroughs Wellcome Advisory Panel 1996-9
Scientific Council, Stazione Zoologica, Naples 1996- 9
President, Society for Developmental Biology, 1999-2000
Burroughs Wellcome Foundation Career Award Panel 2000-4
Damon Runyon/Walter Winchell Award Panel 2000-4
Advisory Board, Princeton University Dept of Molecular Biology, 2003-

Research

Chris Wylie's research studies the early development of vertebrate embryos, using both Xenopus and the mouse as model systems. Current projects include the formation of the ectodermal organs, the control of the actin skeleton in the early embryos, and cell migration in the early vertebrate embryo.

Visit the Wylie-Heasman Lab Site.

Research Grants and Contracts

Maternal Control of Actin Assembly in Xenopus Embryos
NIH R01 HD044764-01A1
2004-2009

Ectoderm Formation in the Early Xenopus Embryo
NIH R01 HD45737-01A1
2004-2009

Presentations

2002

American Society for Cell Biology Annual meeting. San Francisco UCSF, invited seminar
University of California, Berkeley, invited seminar
Baylor Medical College, invited seminar
Howard Hughes Medical Institute/Burroughs Wellcome Fund, course in scientific management for the starting invesigator, invited speaker
The Lynch Lectures, University of Notre Dame International Xenopus meeting, Cambridge UK
Germ Cells, Cold Spring Harbor symposium meeting
Washington University, St. Louis, invited seminar Copenhagen Workshop on Carcinoma in situ and Cancer of the Testis

2003

1st international symposium in Cell and Developmental Biology, RIKKEN Institute, Kobe, Japan
Mount Sinai Medical School, invited seminar
Gordon Conference in Developmental Biology, New Hampshire
Case Western University College of Medicine, invited seminar
The Stowers Institute, Kansas City, invited seminar

2004

International Xenopus meeting, Woods Hole
Northwestern University, Evanston Il., invited seminar
Gordon Conference on Mammalian Development and Reproduction Germ Cells, Cold Spring Harbor symposium meeting
University of Toronto, Samuel Lumenfeld Institute, invited seminar
Princeton University, invited seminar
Institute for Cancer Research, UK, symposium on testicular tumors

Publications, Most Recent

Christopher Wylie's publications as listed by PubMed

Houston D and Wylie C. (2003) The Xenopus LIM-homeodomain protein Xlim5 regulates the differential adhesion properties of early ectoderm cells. Development 130: 2695-2704

Molyneaux K. A., Schaible K, and Wylie C. (2003) gp130, the shared receptor for the LIF/IL6 cytokine family in the mouse, is not required for early germ cell differentiation, but is required cell-autonomously in oocytes for ovulation. Development 130: 4287-4294

Yokota C., Kofron M., Zuck M., Houston D., Isaacs H., Asashima M., Wylie C. and Heasman J. (2003) A novel role for a nodal-related protein; Xnr3 regulates convergent extension movements via the FGF receptor. Development 130: 2199-2212

Molyneaux K.A, Zinszner H., Kunwar P.S., Schaible K., Stebler J., Sunshine M.J., O'Brien W., Raz E., Littman D., Wylie C., and Lehmann R. (2003) The chemokine SDF1/CXCL12 and its receptor CXCR4 regulate mouse germ cell migration and survival. Development 130: 4279-4286

Molyneaux K.A., and Wylie C. (2003) Mechanisms controlling mammalian germ cell migration. Topical Endocrinology 22 1-5

Molyneaux, K.A, and Wylie C. (2003) The genome and the germ cell. Genome Biol. 4 303-5

Sundaram, N, Tao, Q, Wylie, C. and Heasman, J. (2003) The role of maternal CREB in early embryogenesis of Xenopus laevis. Dev Biol. 261: 337-52

Stallock, J., Molyneaux, K., Schaible, K., Knudson, C.M., and Wylie, C. (2003). The pro-apoptotic gene Bax is required for the death of ectopic primordial germ cells during their migration in the mouse embryo. Development 130: 6589-6597

Molyneaux, K., Wang, Y., Schaible, K., and Wylie, C. (2004) Transcriptional profiling identifies genes differentially expressed during and after migration in murine primordial germ cells. Gene Expr.Patterns 4 167-81

Kofron M, Wylie C, Heasman J. (2004) The role of mixer in patterning the early Xenopus embryo. Development 131 2431-41

Kofron, M., Puck, H., Standley, H., Wylie, C., Old, R., Whitman, M., and Heasman, J., (2004) New roles for FoxH1 in patterning the early embryo. Development 131 5065-78

Molyneaux, K., and Wylie, C. (2004) Primordial germ cell migration. Int. J. Dev. Biol. 48 537-44

Stebler, J., Spieler, D., Slanchev, K., Molyneaux, K., Richter, U., Cojocaru, V., Tarabykin, V., Wylie, C., Kessel, M., and Raz, E. (2004) Primordial germ cell migration in the chick and mouse embryo: the role of the chemokine SDF-1/CXCL12. Dev. Biol. 272 351-61