Endocrinology

Susan R. Rose, MD

Appointment

Professor of Pediatrics

Email

susan.rose@cchmc.org

Phone

513-636-4744

Credentials

MD: Case Western Reserve School of Medicine, 1980.

MEd: School Psychology, University of Dayton, 1972.

Residency: The Cleveland Clinic, 1983.

Fellowship: National Institutes of Health, 1986.

Certification: Pediatrics, 1985; Pediatric Endocrinology, 1986.

Awards and Honors

Profile published in Austral-Asian Journal of Cancer, Vol. 6, No.4, October 2007
Eminent Scientist of the Year 2007 North America, World Scientists Forum International Awards
Best Clinical Poster Award, Nineteenth Annual Fanconi Anemia Research Fund Scientific Symposium, October 9, 2007, Chicago, IL
The Best Doctors in America, 1996-2008
Guide to America's Top Pediatricians, 2004-2005
Who'sWho in Medicine and Healthcare, 1997 to 2000
Who'sWho in the South and Southwest, 1996 to 2000
Young Investigator Award, Southern Society of Pediatric Research, 1995
Community Service Award recognizing role in mentoring high school students in science research, American Medical Women's Association, 1994
Certificate of Recognition for Invaluable Assistance in the Education and Training of Medical Students, University of New Mexico School of Medicine, 1991 / 1992

Research Grants and Contracts

Pfizer Global Pharmaceuticals, Endocrinopathies after head injury, PI Susan R. Rose, $80,300, (#GA90005Z), 2006-2008.

Fanconi Anemia Foundation, Thyroid hormone in Fanconi anemia, PI Susan R Rose, $30,000, 2004-2007.

NIH, A pilot trial of oxandrolone for the treatment of bone marrow aplasia in patients with Fanconi anemia, PI Franklin O. Smith (partial salary support)

NIH, Bone mineral density in childhood study, PI Heidi Kwalkwarf (partial salary support)

NIH, Triptorelin for ovary protection in childhood onset lupus, PI Hermine Brunner (partial salary support)

Endocrinopathies in Fanconi anemia, PI Susan R Rose

Publications, Most Recent

Growth Charts, Slide Sets

Rose SR. Growth charts for Children with Noonan Syndrome. Novo Nordisk, 2007.

Biller B, Nishi Y, Rose S, Schmiegelow K, Shalet S, Sklar C, Toogood A, Waguespack SG, Yafi M, Yokoya S. Childhood cancer survivors: a slide kit on efficacy and safety of GH treatment. Novo Nordisk, 2006.

Rose SR. Growth charts with SD Z-score lines for height and body mass index, children and infants, plus chart for SGA, based on NCHS data. Novo Nordisk, 2006.

Book Chapters

Rutter M, Racine M, Rose SR. The Endocrine Society's 89th Annual Meeting, Toronto, June, 2007. In Highlights, Volume 15, 2007, Medical Forum International BV, Zeist, The Netherlands, pp 1-33.

Cameron F, Rose SR, et al. 45th Meeting of the European Society for Paediatric Endocrinology, Helsinki, Finland, June, 2007. In Highlights, Volume 15, 2006, Medical Forum International BV, Zeist, The Netherlands.

Dawodu A, Rose SR. Thyroid disease. In The 5-Minute Obstetrics and Gynecology Consult. Ed: PJ Adams Hillard, Lippincott, Williams and Wilkins, 2007.

Eyal O, Rose SR. Thyroid disease. In Rogers Textbook of Pediatric Intensive Care. Ed: Rogers, Lippincott, 2007.

Burns KC, Rose SR. Endocrine Sequellae of Pediatric Malignancies.AACE Self-Assessment Profile in Endocrinology and Metabolism. Ed. Speiser P, Palumbo PJ. 2007.

Rose SR. Growth hormone deficiency: Growth hormone tests and growth hormone measurements. In Growth Hormone Therapy in Pediatrics—20 Years of KIGS. Eds. MB Ranke, Price DA, Reiter EO. Karger, Basel. 2007, pp38-46.

Cameron F, Rose SR, et al. 44th Meeting of the European Society for Paediatric Endocrinology, Rotterdam, The Netherlands, July, 2006. In Highlights, Volume 14, 2006, Medical Forum International BV, Zeist, The Netherlands.

Sundararajan S, Racine M, Rose SR. The Endocrine Society's 88th Annual Meeting, Boston, June, 2006. In Highlights, Volume 14, 2006, Medical Forum International BV, Zeist, The Netherlands, pp 1-33.

Leung W, Rose SR, Merchant TE. Neuroendocrine complications of cancer therapy. In Survivors of Childhood and Adolescent Cancer, 2nd Edition, ed Schwartz CL, pp 51-80. Springer-Verlag GmBH & Co, Berlin, 2005.

Rose SR. The thyroid. In Neonatal - Perinatal Medicine: Diseases of the Fetus and Infant. 8TH Edition. Editors: AA Fanaroff & RJ Martin. Mosby, Inc, St Louis, 2006, volume 2, pp 1523-50.

Achermann J, Cameron F, Rose SR. Overnight Reports, ESPE/LWPES 7th Joint Meeting Paediatric Endocrinology, Lyon, France, 2005, Medical Forum International BV, Zeist, The Netherlands.

Racine M, Sundararajan S, Rose SR. Summary of the 87th Annual Meeting of the Endocrine Society, San Diego, CA, June 2005. In Highlights, Volume 13, 2005, Medical Forum International BV, Zeist, The Netherlands, pp 1-37.

Allen D, Rose SR, Reiter E. Normal growth and growth disorders. In Principles and Practice of Pediatric Endocrinology. Editors: MS Kappy, DB Allen, ME Geffner. Charles C. Thomas Publisher, LTD, Springfield, IL. 2005, pp 77-216.

Review articles

Lee PA, Rose SR. Use of GnRH agonists in GH-deficient patients: Arguments for and against.Pediatric Endocrinology Reviews (In press) 2008.

Rose SR. Mechanisms of hypothalamic-pituitary injury in oncology survivors.The Endocrinologist (in press) March-April, 2008.

Rose SR. Obesity and growth disorders: Honoring George A Burghen.The Endocrinologist 2007; 17: 267-72.

Rutter MM, Rose SR. Long-term endocrine sequelae of childhood cancer.Curr Opin Pediatr 2007; 19: 480-7.

Rose SR. TSH above 3 is not usually normal.The Endocrinologist 2006; 16: July- Aug.

American Academy of Pediatrics; Rose SR; Section on Endocrinology and Committee on Genetics, American Thyroid Association; Brown RS; Public Health Committee, Lawson Wilkins Pediatric Endocrine Society; Foley T, Kaplowitz PB, Kaye CI, Sundararajan S, Varma SK. Update of newborn screening and therapy for congenital hypothyroidism, from the AAP Section on Endocrinology and Committee on Genetics, American Thyroid Association Public Health Committee, and Lawson Wilkins Pediatric Endocrine Society.Pediatrics 2006; 117: 2290-2303.

Rose SR. Update: ACTH: Hidden hormone deficiency in cancer survivors. In: UpToDate, Rose, BD (Ed), UpToDate, Waltham, MA, 2005.

Rose SR. Update: Endocrine surveillance in childhood cancer survivors. In: UpToDate, Rose, BD (Ed), UpToDate, Waltham, MA, 2005.

Kaplowitz P and AAP Section on Endocrinology. Focus on Subspecialites: Guidelines for pediatricians with regard to which short children would benefit from a referral to a pediatric endocrinologist.AAP News, Dec, 2005

Schwartz R, Rose SR, Root A. Update in pediatric endocrinology, Audiotape and Text for CME

Rose SR, Vogiatzi MG, Copeland KC. A general pediatric approach to evaluating a short child.Pediatr Rev. 2005; 26:410-20.

Rose SR. Workshop on Turner Syndrome: How can very early treatment start and/or GH dosing based on IGF-I titrating improve treatment outcome in young Turner women? Medical Forum International BV, Zeist, The Netherlands. 2005, Vienna, Austria, p 1-8.

Article review and comment

Rose SR. Commentary: Will we miss confirming GHD in adult GH retesting after irradiation?International Growth Monitor. 2006; 16 (1):13-14.

Rose SR. Commentary: Low growth hormone after childhood Cushing disease.International Growth Monitor. 2004; 14 (2): 9-10.

Rose SR. Commentary: Adult height after growth hormone therapy after childhood brain tumours.International Growth Monitor. 2004; 14 (1): 11-12.

Journals

Razlauskaite R, Evans AT, Villabona CV, Abdu T, Ambrosi B, Atkinson B, Choi CH, Courtneey H, Gonc N, Maghnie M, Rose SR, Tordjman K, Oelkers W, Soule S. Meta-analysis of tests for hypothalamic-pituitary adrenal insufficiency: Low-dose corticotrophin test is superior to standard-dose. (in preparation)

Eyal O, Blum S, Mueller R, Smith F, Rose SR. Improved growth velocity during thyroid therapy of subtle hypothyroidism in Fanconi Anemia. (in preparation)

Van der Kaay D, Rose SR, de Jong F, Odink R, Bakker-van Waarde W, Sulkers E, Hokker-Koelega A. Overnight levels of luteinizing hormone, follicle stimulating hormone and growth hormone before and during GnRHa treatment in short girls born small for gestational age. (in preparation)

Van der Kaay D, de Jong F, Rose SR, Odink R, Bakker-van Waarde W, Sulkers E, Hokker-Koelega A. Overnight levels of luteinizing hormone, follicle stimulating hormone and growth hormone before and during GnRHa treatment in short boys born small for gestational age. (submitted)

Elder D, D'Alessio DA, Eyal O, Mueller R, Smith F, Kansra A, Rose SR. Abnormalities in glucose tolerance are common in children with Fanconi anemia and associated with impaired insulin secretion. (submitted)

Dorn L Rotenstein D, Rose SR, Berga S, Louks T. Differences in endocrine parameters and psychopathology in girls with premature adrenarche versus on-time adrenarche.J Pediatr Endocrinol Metab (in press) 2007

May M, Rose SR. Oral hydration during growth hormone stimulation with clonidine.J Pediatr Nurs 2007; 22: 383-7.

Leung W, Ahn H, Rose SR, Phipps S, Smith T, Gan K, O'Connor M, Hale GA, Kasow KA, Barfield RC, Madden RM, Pui CH. A prospective cohort study of late sequelae of pediatric allogenic hematopoietic stem cell transplantation.Medicine
2007; 86: 215-24.

Inge TH, Pfluger P, Zeller M, Rose SR, Burget L, Sundararajan S, Daniels SR, Tschoep M. Gastric bypass for treatment of hypothalamic obesity after craniopharyngioma therapy.Nat Clin Prac Endocrinol Metab 2007; 3: 606-9.

Rose SR. Pharmacologic and physiologic regulators of the nocturnal TSH surge; A clinical research center study.Recent Advances and Research Updates. ISSN 0972-4699, 2007; 8:219-29.

Sherafat-Kazemzadeh R, Mehta SN, Care MM, Kim MO, Williams DA, Rose SR, and the FA Comprehensive Care Center. Small pituitary size in children with Fanconi Anemia.Pediatr Blood Cancer 2007; 49: 166-70.

Razzouk BI, Rose SR, Hongeng S, Wallace D, Smeltzer MP, Zacher M, Pui C-H, Hudson MM. Obesity in survivors of childhood acute lymphoblastic leukemia and lymphoma.J Clin Oncol 2007; 25:1183-89.

Eyal O, Sundararajan S, Inge TH, Rose SR. Obesity in patients with craniopharyngioma.The Endocrinologist 2006;16:286-93.

Kaste SC, Rai SN, Fleming K, McCammon EA, Tylavsky FA, Danish RK, Rose SR, Sitter CD, Pui CH, Hudson MM. Changes in bone mineral density in survivors of childhood acute lymphoblastic leukemia.Pediatr Blood Cancer 2006; 46:77-87.

Rose SR, Shulman DI, Larsson P, Wakley LR, Wills S, Bakker B. Gender does not influence prepubertal growth velocity during growth hormone therapy—Analysis of United States KIGS data.J Pediatr Endocrinol Metab 2005;18:1045-51.

Lomenick JP, Smith WJ, Rose SR. Autoimmune thyroiditis in patients with 18q deletion syndrome.J Pediatr 2005; 147:541-3.

Quigley CA, Gill AM, Crowe BJ, Roberts K, Chipman JJ, Rose SR, Ross JL, Cassorla FG, Wolka AM, Wit JM, Rekers-Mombarg LTM, Cutler GB Jr. Safety of growth hormone treatment in pediatric patients with idiopathic short stature.J Clin Endocrinol Metab 2005;90:5188-96.

Schaub RL, Hale D, Rose SR, Leach RJ, Cody JD. The spectrum of thyroid abnormalities in individuals with 18q deletions.J Clin Endocrinol Metab 2005; 90: 2259-63.

Rose SR, Danish RK, Kearney NS, Schreiber RE, Lustig RH, Burghen GA, Hudson MM. ACTH deficiency in childhood cancer survivors.Pediatr Blood Cancer 2005;45:808-13.

Abstracts, Presented and Published

Kaulfers AM, Blum S, Backeljauw PF, Rose SR. Endocrinopathies after head injury in children.Pediatric Res 2008 abst

Kaulfers AM, Blum S, Reifschneider K, Backeljauw PF, Rose SR. Endocrinopathies after head injury in children.
European Pediatric Endocrine Society. Horm Res 2007, 68 (suppl 1): 184, abst P02-591.

Eyal O, Blum S, Rose SR, and the FA Comprehensive Care Center. Improved growth velocity during thyroid therapy of subtle hypothyroidism in Fanconi Anemia. The Endocrine Society's 89th Annual Meeting, 2007, abst P2-505. Also, Nineteenth Annual Fanconi Anemia Research Fund Scientific Symposium 2007, Chicago, IL.

Dorn L, Rotenstein D, Rose S, Clark L, Jillard C, Grimes S. What about adrenarche: Do adrenal androgens have activating effects on mood and behavior? Society for Research on Adolescence, Biennial meeting, 2006.

Kazlauskaite R, Villabona CV, Tordjman K, Rose SR, Choi CH, Ambrosi B, Maghnie M, Nazli Gönç E, Evans A. Meta-analysis of ACTH-analog stimulation testing in central adrenal insufficiency. The Endocrine Society's 88th Annual Meeting, 2006, abst P3-732.

Rose SR, May M. Oral hydration during arginine-clonidine test. The Endocrine Society's 88th Annual Meeting, 2006, abst P2-666.

Reifschneider K, Blum SD, Weiss M, Rose SR. Endocrinopathies after head injury in children. The Endocrine Society's 88th Annual Meeting, 2006, abst P1-826.

FO Smith, P Kelly, R Harris, SR Rose, M Altaye, S Radtke, M Haren, DA Williams. A Pilot Trial of Oxandrolone for the Treatment of Bone Marrow Failure (BMF) in Patients with Fanconi Anemia (FA). Seventeenth Annual Fanconi Anemia Research Fund Scientific Meeting, Geneva, Switzerland, September, 2005.

Kansra A, Rose SR, Fanconi Anemia Comprehensive Center. Fanconi Anemia and diabetes. LWPES/ ESPE 7th Joint Meeting, Lyon, France. Horm Res 2005; 64 (suppl 1): 142, abst #481.

Sherafat R, Mehta S, Williams D, Rose SR. Pituitary size in Fanconi Anemia. The Endocrine Society's 87th Annual Meeting, 2005, abst P2-500.

Editing

Scientific Editor of Highlights, a quarterly international journal of invited articles focusing on developmental issues of childhood growth, published by Medical Forum, The Netherlands, 1992 to present.

Editor, with Deborah Jones: Chronic Renal Failure by F. Perfumo. Medical Forum International, The Netherlands, 1998.

Professional Organization Memberships

Fellow of the American Academy of Pediatrics (FAAP): Executive Committee, Endocrine Section
American Academy of Pediatrics, Ohio Chapter
The Endocrine Society
Growth Hormone Research Society (GRS)
Lawson Wilkins Pediatric Endocrine Society (LWPES)
Pediatric Endocrine Alliance for Neuro-Oncology Patients (PEANOP)
Southern Pediatric Endocrine Society (SPES)
Women in Endocrinology