Fukun Guo, PhD
Title
Research Instructor
Email
fukun.guo@cchmc.org
Phone
513-803-0940
Fax
513-636-3768
Credentials
BS: Jilin University, China, 1994
MS: Academy of Military Medical Sciences, China, 1997
PhD: First Military Medical University, China, 2000
Postdoctoral Research Associate: University of Tennessee, Memphis, TN, 2002
Postdoctoral Research Associate: Cincinnati Children's Hospital Medical Center, Cincinnati OH 2002-2004
Research Associate: Southern Medical University, Guangzhou, Guangdong, China, 2000Research
Research Assocaite: Cincinnati Childrens Hospital Medical Center, Cincinnati, OH 2004
Research Instructor: Cincinnati Children's Hospital Medical Center, Cincinnati, OH 2005-present
Awards and Honors
- University of Cincinnati College of Medicine, Poster Session Award (Second place), 2004
- The General Logistics Department of the Chinese People’s Liberation Army, Outstanding Contribution Award (Second-class), 2001
- Chinese Academy of Sciences, Scholarship, 2000
- Outstanding Postgraduate, Guangdong province, China, (First-class), 2000
Research
Rho GTPases and T and B lymphocyte development and function
Research Grants and Contracts
Genetic and biochemical evaluation of Rac1 GTPase signaling mechanism in primary cells. Principal Investigator. Beginning-Grant-In-Aid, American Heart Association. 2007-2009.
Physiological Role of Cdc42 in T Cell Polarity. Principal Investigator. Trustee Grant, Cincinnati Children’s Hospital Medical Center. 2009-2011.
Publications, Most Recent
Connect to Fukun Guo's publications on PubMed
1. Fukun Guo, Chinavenmeni S. Velu, H. Leighton Grimes, Yi Zheng. Rho GTPase Cdc42 is essential for B lymphocyte development and activation. Blood, 114(14):2909, 2009.
2. Fukun Guo, Jose A. Cancelas, David Hildeman, David A. Williams, Yi Zheng. Rac GTPase isoforms, Rac1 and Rac2, play a redundant and crucial role in T-cell development. Blood, 112 (5): 1767, 2009.
3. Xiaoling Zhang, Xun Shang, Fukun Guo, Kim Murphy, Michelle Kirby, Patrick Kelly, Lilith Reeves, Franklin O. Smith, David A. Williams, Yi Zheng, Qishen Pang. Defective homing is associated with altered Cdc42 activity in cells from Fanconi anemia group A patients. Blood, 112 (5):1683, 2009.
4. Fukun Guo, Marcella Debidda, Linda Yang, David A. Williams, Yi Zheng. Genetic deletion of Rac1 GTPase reveals its critical role in actin stress fiber formation and focal adhesion complex assembly. Journal of Biological Chemistry, 281(27):18652, 2006.
5. Nóra Nusser, Elvira Gosmanova, Natalia Makarova, Yuko Fujiwara, Linda Yang, Fukun Guo, Yongneng Luo, Yi Zheng and Gábor Tigyi. Serine phosphorylation differentially affects RhoA binding to effectors: Implications to NGF-induced neurite outgrowth. Cellular Signalling, 18(5):704, 2006.
Presentations, Most Recent
Fukun Guo, Wei Liu, Kaari Lynch, Jose Cancelas, George Thomas, Sara Kozma, Yi Zheng. Role of mTOR in hematopoiesis and hematopoietic stem cell regulation. Presented at the 7th Midwest blood club annual symposium. Cincinnati, OH. April 30-May 1, 2009.
Fukun Guo, Yi Zheng. The Rho GTPase Cdc42 is essential for B lymphocyte development and activation. Presented at the 50th ASH annual meeting. San Francisco, CA. December 6-9, 2008.
Fukun Guo, David Hildeman, Jun Mo, Yi Zheng. Gene targeting of Cdc42 reveals its essential role in T cell development and homeostasis. Presented at the 49th ASH annual meeting. Atlanta, GA. December 8-11, 2007.
Fukun Guo, David Hildeman, Yi Zheng. Cdc42 is essential for T-cell development and activation. Presented at the 35th Annual Autumn Immunology Conference. Chicago, IL. November 17-20, 2006.
Professional Organization Memberships
- Active member of the American Association for Cancer Research
- Active member of the American Society of Hematology
