Fukun Guo, PhD
Title
Research Instructor
Email
fukun.guo@cchmc.org
Phone
513-803-0940
Fax
513-636-3768
Credentials
BS: Jilin University, China, 1994
MS: Academy of Military Medical Sciences, China, 1997
PhD: First Military Medical University, China, 2000
Awards and Honors
- Outstanding Poster Award, University of Cincinnati College of Medicine (2004)
- Outstanding Contribution Award, The General Logistics Department of the Chinese People's Liberation Army (2001 )
- Outstanding Postgraduate, Guangdong province, China (2000)
- Scholarship of the Chinese Academy of Sciences (2000)
Research Grants and Contracts
2007-2009: American Heart Association Beginning-Grant-In-Aid, “Genetic and biochemical evaluation of Rac1 GTPase signaling mechanism in primary cells” (PI: Fukun Guo).
Publications, Most Recent
Connect to Fukun Guo's publications on PubMed
Nusser N, Gasmanova E, Makarova N, Fujiwara Y, Yang L, Guo F, Luo Y, Zheng Y, Tigyi G. Serine phosphorylation differentially affects RhoA binding to effectors: Implications to NGF-induced neurite outgrowth.Cell Signal. 2006, 18(5): 704-714.
Guo F, Debidda M, yang L, Williams DA, Zheng Y. Genetic deletion of Rac1 GTPase reveals its critical role in actin stress fiber formatino and focal adhesion complex assembly.J Biol Chem. 2006;281(27): 18652-18659.
Vanni C, Ottaviano C, Guo F, Puppo M, Varesio L, Zheng Y, Eva A. Constitutively active Cdc42 mutant confers growth disadvantage in cell transformation.Cell Cycle. 2005 Nov;4(11):1675-82.
Nusser N, Gosmanova E, Makarova N, Fujiwara Y, Yang L, Guo F, Luo Y, Zheng Y, Tigyi G. Serine phosphorylation differentially affects RhoA binding to effectors: Implications to NGF-induced neurite outgrowth.Cell Signal. 2005 Aug 15; [Epub ahead of print].
Skowronek KR, Guo F, Zheng Y, Nassar N. The C-terminal basic tail of RhoG assists the guanine nucleotide exchange factor Trio in binding to phospholipids.J Biol Chem. 2004 Sep 3;279(36):37895-907.
Gao Y, Dickerson JB, Guo F, Zheng J, Zheng Y. Rational design and characterization of a Rac GTPase-specific small molecule inhibitor.Proc Natl Acad Sci U S A. 2004 May 18;101(20):7618-23.
Debreceni B, Gao Y, Guo F, Zhu K, Jia B, Zheng Y. Mechanisms of guanine nucleotide exchange and Rac-mediated signaling revealed by a dominant negative trio mutant.J Biol Chem. 2004 Jan 30;279(5):3777-86.
Guo F, Zheng Y. Rho family GTPases cooperate with p53 deletion to promote primary mouse embryonic fibroblast cell invasion.Oncogene. 2004 Jul 22;23(33):5577-85.
Guo F, Zheng Y. Involvement of Rho family GTPases in p19Arf- and p53- mediated proliferation of primary mouse embryonic fibroblasts.Mol Cell Biol. 2004 Feb;24(3):1426-38.
Guo F, Gao Y, Wang L, Zheng Y. The p19Arf-p53 tumor suppressor pathway regulates cell motility by suppression of PI3 kinase and Rac1 GTPase activities.J Biol Chem. 2003 Apr 18;278(16):14414-9.
Professional Organization Memberships
American Association for Cancer Research (2002-present)
Special Interests
Rho GTPases and T and B lymphocyte development and function
