Experimental Hematology and Cancer Biology

Paul R. Andreassen, PhD

Appointment

Assistant Professor of Pediatrics

Email

paul.andreassen@cchmc.org

Phone

(513) 636-0499

Fax

(513) 636-3768

Credentials

BS: Willamette University, Salem, Oregon, 1984

PhD: University of Washington, Seattle, Washington, 1995

Position History

2006-Present: Member, Graduate program in Cancer and Cell Biology, University of Cincinnati, Cincinnati, OH.
2004-Present: Assistant Professor of Pediatrics, Cincinnati Children's Hospital Medical Center, Division of Experimental Hematology, Leukemia Biology Program, Cincinnati, OH.
2000-2004: Postdoctoral Research Fellow, Department of Pediatric Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA.
1993-1999: Researcher, Institut de Biologie Structurale (CEA-CNRS), Grenoble, France.
1986-1992: Predoctoral Research Fellow, Department of Pathology, Fred Hutchinson Cancer Research Center and the University of Washington, Seattle, WA.

Awards and Honors

Special Fellow Award, Leukemia and Lymphoma Society (2001-2004)

Magna Cum Laude, Willamette University (1984)

Research

Connect to Paul Andreassen's laboratory page

Our research focuses on the relationship of cell cycle checkpoints and DNA damage responses to the genetic instability that underlies the development of cancer. We are studying the rare disease Fanconi Anemia (FA) to gain insight into this process. FA is characterized by chromosome instability, progressive bone marrow failure, and a predisposition to leukemia and other cancers. The lab is using biochemical, genetic, and cell biological approaches to understand the regulation and function of FA proteins in DNA repair.

Research Grants and Contracts

NIH R01 HL085587 (PI: Paul Andreassen)

National Heart, Lung, and Blood Institute 7/8/2008 - 6/30/2013

"FANCD2 monoubiquitination in DNA damage responses"

Publications, Most Recent

Connect to Paul Andreassen's publications on PubMed

Krejci O, Wunderlich M, Geiger H, Chou FS, Schleimer D, Jansen M, Andreassen PR and Mulloy JC. p53 signaling in response to increased DNA damage sensitizes AML-ETO cells to stress-induced death.Blood 2008 111:2190-2199.

Andreassen PR, Ho GP, D'Andrea AD. DNA damage responses and their many interactions with the replication fork. Carcinogenesis. 2006 27:883-892.

Cantor SB and Andreassen PR. Assessing the link between BACH1 and BRCA1 in the FA pathway. Cell Cycle. 2006 Jan;5(2):164-7.

Litman R, Peng M, Jin Z, Zhang F, Zhang J, Powell S, Andreassen PR and Cantor SB. BACH1 is critical for homologous recombination and appears to be the Fanconi anemia gene product FANCJ.Cancer Cell. 2005 Sep;8(3):255-65.

Montes de Oca R, Andreassen PR, Gregory RC, Taniguchi T, Houghtaling S, Grompe M and D'Andrea AD. Regulated interaction of the Fanconi Anemia protein, FANCD2, with chromatin.Blood. 2005 Feb 1;105(3):1003-9.

Skoufias DA, Lacroix FB, Andreassen PR, Wilson L, Margolis RL. Inhibition of DNA decatenation, but not DNA damage, arrests mammalian cells at metaphase.Mol Cell. 2004 Sep 24;15(6):977-90.

Andreassen PR, Skoufias D and Margolis RL. Analysis of the spindle assembly checkpoint in HeLa cells.Methods Mol Biol. 2004;281:213-25.

Andreassen PR, D'Andrea AD and Taniguchi T. Phosphorylation by ATR couples FANCD2 monoubiquitination to the DNA damage response.Genes Dev. 2004 Aug 15;18(16):1958-63.

Wang XZ, Andreassen PR, and D'Andrea AD. Functional Interaction of FANCD2 and BRCA2/FANCD1 in chromatin.Mol Cell Biol. 2004 Jul;24(13):5850-62.

Andreassen PR, Lohez OD and Margolis RL. G2 and spindle assembly checkpoint adaptation, and tetraploidy arrest: implications for intrinsic and chemically induced genomic instability.Mutat Res. 2003 Nov 27;532(1-2):245-53. Review.

Mollinari C, Reynaud C, Martineau-Thuillier S, Monier S, Kieffer S, Garin J, Andreassen PR, Boulet A, Goud B, Kleman J-P and Margolis RL. The mammalian passenger protein TD-60 is an RCC1 family member with an essential role in prometaphase to metaphase progression.Dev Cell. 2003 Aug;5(2):295-307.

Margolis RL, Lohez OD and Andreassen PR. G1 tetraploidy checkpoint and the suppression of tumorigenesis. J Cell Biochem. 2003 Mar 1;88(4):673-83. Review.

Lohez OD, Lacroix FB, Borel F, Andreassen PR and Margolis RL. Arrest of mammalian fibroblasts in G1 in response to actin inhibition is dependent on retinoblastoma pocket proteins but not on p53.J Cell Biol. 2003 Apr 14;161(1):67-77.