Experimental Hematology and Cancer Biology

Ruhikanta A. Meetei, PhD

Appointment

Assistant Professor

Email

ruhikanta.meetei@cchmc.org

Phone

513-636-1768

Fax

513-636-3768

Credentials

BS: Manipur University, India, 1989

MS: Manipur University, India, 1992

PhD: Indian Institute of Science, Bangalore, India, 2000

Awards and Honors

American Society of Hematology Junior Faculty Scholar Award (2006-08)
Discovery Award at the 2005 FARF Scientific Symposium for the cloning of the FANCB and FANCM genes (2005)
Appreciation Award at the 2003 FARF Scientific Symposium for the discovery of the FANCL gene (2003)
Senior Research Fellowship award, Council of Scientific and Industrial Research Government of India,New Delhi (1996-1999)
Junior Research Fellowship award, Council of Scientific and Industrial Research Government of India, New Delhi (1993-1995)
State Merit Scholarship award, Government of Manipur, India(1983-1989)

Research

Research in my laboratory focuses on functional analysis of Fanconi anemia gene products. The major research focus includes identification of new FA genes and signal transduction pathways that regulate DNA damage induced activation of the FA-core complex. Important technologies include biochemical purification of multiprotein complexes from human cell extracts, immunoprecipitation, RNAi, and biochemical assays. My long-term research goal is to use Fanconi anemia as a model system to study some of the important fundamental questions of cancer biology in general.

Publications, Most Recent

Connect to Ruhikant Meetei's publications on PubMed

Meetei AR, Medhurst AL, Ling C, Xue Y, Singh TR, Bier P, Steltenpool J, Stone S, Dokal I, Mathew CG, Hoatlin M, Joenje H, de Winter JP, Wang W. A human ortholog of archaeal DNA repair protein Hef is defective in Fanconi anemia complementation group M. Nat Genet. 2005 Sep;37(9):958-63.

Yin J, Sobeck A, Xu C, Meetei AR, Hoatlin M, Li L, Wang W. BLAP75, an essential component of Bloom's syndrome protein complexes that maintain genome integrity.EMBO J. 2005 Apr 6;24(7):1465-76.

Meetei AR, Levitus M, Xue Y, Medhurst AL, Zwaan M, Ling C, Rooimans MA, Bier P, Hoatlin M, Pals G, de Winter JP, Wang W, Joenje H. X-linked inheritance of Fanconi anemia complementation group B.Nat Genet. 2004 Nov;36(11):1219-24.

Meetei AR, Yan Z, Wang W. FANCL replaces BRCA1 as the likely ubiquitin ligase responsible for FANCD2 monoubiquitination.Cell Cycle. 2004 Feb;3(2):179-81.

Meetei AR, de Winter JP, Medhurst AL, Wallisch M, Waisfisz Q, van de Vrugt HJ, Oostra AB, Yan Z, Ling C, Bishop CE, Hoatlin ME, Joenje H, Wang W. A novel ubiquitin ligase is deficient in Fanconi anemia.Nat Genet. 2003 Oct;35(2):165-70.

Meetei AR, Sechi S, Wallisch M, Yang D, Young MK, Joenje H, Hoatlin ME, Wang W. A multiprotein nuclear complex connects Fanconi anemia and Bloom syndrome.Mol Cell Biol. 2003 May;23(10):3417-26.