| Li Guo, PhD Research Fellow 513-636-3502 |
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I am currently studying the role of Rho GTPases Rac1 and Cdc42 in Schwann cell growth and tumorigenesis. I like working in this lab because the people are nice, and the work is creative. It is good if we can find answers for unknown things by running experiments, and it is great if our findings can contribute to understanding and treating human disease.
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| Walter Jessen, PhD Research Associate 513-636-0955 |
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I am currently working to assemble and mine multi-experiment datasets generated by the Ratner lab and the NF1 Microarray Consortium, including GeneChip data from human and mouse models of NF1, NF2 and Schwannomatosis. The analyses of Schwann cells and human tumors have already provided a number of novel targets for preclinical study.
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| Edwin Jousma, MS Visiting Research Scientist 513-636-3502 |
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I am working in the framework of the NF1 pre-clinical therapeutic trial. We are screening candidate drugs that may prevent neurofibromas from growing. In order to do so, mice are given drugs daily and tumor growth and development are tracked by MRI. I joined the Ratner lab in July, 2008, coming from Amsterdam, the Netherlands. I like working here: it’s a very positive environment with inspiring people! |
| Nate KolasinskiLaboratory Aide, UC Pre-Med Student 513-636-3502 |
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As the undergraduate student helper in Dr. Ratner's Lab, my duties include keeping the lab's work areas stocked with various supplies and autoclaved items, properly taking care of all animal cages and bodies, and genotyping the mice in Dr. Mayes' colonies. I also have the fortune of working with Deanna and Sara on a small portion of their TC21/R-Ras2 project. I am extremely grateful for the opportunity Dr. Ratner has given me. I love working here because Dr. Ratner and her staff continually challenge me intellectually, and absolutely everyone here is willing to help me in my endeavors! |
| Debra Mayes, PhD Research Fellow 513-636-3502 |
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NF1 and Ras activation in oligodendrocyte progenitor cell development and myelination” - This project focuses upon the role and mechanism of the Nf1 protein in regulating oligodendrocyte progenitor cell proliferation and differentiation within the brain. I joined Nancy’s lab in June 2006. I love coming to work because Nancy is a very genuine mentor who allows the people in her lab a great deal of intellectual freedom. All the projects are challenging, interesting, and have the potential to become translational. Because of this, I feel I can impact people’s lives through my work.
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| Chandra Moon, BS Research Assistant II 513-636-3502 |
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I joined Nancy's lab in August 2007. I recently began a project studying Rac1 and Cdc42 function in conjunction with Li Guo. My main responsibilities are managing the lab and maintaining mouse colonies. Working in Nancy’s lab has allowed me the opportunity learn cutting-edge techniques while working with some of the world’s most renowned scientists.
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| Deanna Patmore, BS UC Graduate Student 513-636-3502 |
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Along with other members of the lab, I am interested in knowing if the effects of neurofibromin mutation, unrelated to Ras-GTP, can be explained by the activation of the Ras protein of R-Ras2/TC21.
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| Melissa Rawe, BS UC Graduate Student 513-636-3502 |
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I am a University of Cincinnati co-op student here in the Ratner lab. This job is allowing me to take my academic knowledge and apply it in the real world. This hands on experience has been priceless, I know that all of the skills I have acquired here will help me successfully meet my career goals. I am learning new things every day. Currently, I am working on a drug screening project comparing efficacy of various compounds between NF related and sporadic MPNSTs. Using this approach we hope to find new compounds that specifically target NF1 mutant cells.
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| Tilat Rizvi, PhD Assistant Professor (513636-4323 |
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I have been working with Dr. Nancy Ratner for many years. Dr. Ratner is a very successful scientist running 8-10 projects side-by-side, providing a wonderful opportunity for scientific interaction and healthy discussion. My main interest of research is oligodendrocytes in relation to demyelination and remyelination using mouse model system for human disease Neurofibromatosis Type 1 (NF1).
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| Sara Welch Research Assistant IV 513-636-3502 |
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I work on the TC21 R-Ras2 project. Ras and nonRas mediated pathways need to be more fully understood to develop more effective therapies. We have some exciting mouse models that will help us study TC21 with in vitro and in vivo techniques. I have worked in Nancy's lab since Dec. 2005. Working at Children's Hospital and specifically in Nancy's lab is great. It is a friendly, cooperative environment which is wonderful for research.There are always new things to learn. We also have this shiny new research building where we do our experiments |
| Jianqiang Wu, M.D., M.S. Research Instructor 513-636-3502 |
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Current projects I am working on include Neurofibroma origin in neurofibromatosis type 1 (NF1) and Preclinical therapeutic trial on neurofibromas. I like working in the Ratner lab because we have a good team and the members are willing to help each other.
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| Rachel Oberst, BS UC Graduate Student 513-636-3502 |
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| Bob Hennigan, PhD Visiting Research Scientist 513-636-3502 |
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