Mulloy Lab

James C. Mulloy, PhD

Title

Assistant Professor of Pediatrics in Experimental Hematology

Appointment

Assistant Professor of Pediatrics, University of Cincinnati

Email

james.mulloy@cchmc.org

Phone

513-636-1844

Fax

513-636-3768

Credentials

BA: (Biology), cum laude, St. Anselm College, Manchester, New Hampshire, 1986

MS: (Microbiology), Rutgers University-University of Medicine and Dentistry, New Brunswick, New Jersey, 1989

PhD: (Microbiology), Rutgers University-University of Medicine and Dentistry, New Brunswick, New Jersey, 1992

Position History

2007-present: Member, Graduate Program in Molecular and Developmental Biology, Cincinnati Children’s Hospital, Cincinnati OH

2006-present: Member, Graduate Program in Cancer and Cell Biology, University of Cincinnati, Cincinnati OH

2003-present: Assistant Professor of Pediatrics, CCHMC, Division of Experimental Hematology, Leukemia Biology Program, Cincinnati OH

2001-2003: Senior Research Scientist, Sloan-Kettering Institute, New York NY

1998-2001: Research Associate, Sloan-Kettering Institute, New York NY

1997-1998: NCI Biotechnology Fellow, Basic Research Laboratory, National Cancer Institute, National Institutes of Health, Bethesda, Maryland

1992-1997: Intramural Research Fellow, Laboratory of Tumor Cell Biology, National Cancer Institute, National Institutes of Health, Bethesda, Maryland

1990-1992: Graduate Assistant, Department of Pathology, University of Medicine and Dentistry-Robert Wood Johnson Medical School, New Brunswick, New Jersey

1986-1990: Teaching Assistant, Department of Microbiology and Molecular Genetics, Rutgers University, New Brunswick, New Jersey

Awards and Honors

2001-2006: The Howard Temin Award, K01 CA90370-01 Research Grant , received from the National Cancer Institute, NIH

Research

Connect to Jim Mulloy's laboratory webpage

Research Grants and Contracts

K01 CA90370      05/16/01 – 04/30/06
NIH/NCI
Role of AML1/ETO in Hematopoiesis and Leukemogenesis
Role: Principal Investigator

Translational Research Initiative     07/01/03 – 06/30/04
CCHMC
The Nerve Growth Factor Receptors in Acute Leukemia:
Implications for Therapeutic Intervention
Role: Principal Investigator

CancerFree Kids Pediatric Cancer Research Alliance         04/01/05 – 03/31/06
Identification of the Genes Regulated by Leukemia Fusion
Proteins and the Role They Play in Leukemia Development
Role: Principal Investigator

UC Cancer Center Pilot Grant      03/01/06 – 02/28/07
Genetic screen for pathways cooperating with AML1-ETO
in leukemia induction (relinquished due to overlapping new award)
Role: Principal Investigator

UC Cancer Center Pilot Grant      12/01/06 – 06/30/07
A Novel Model of MLL-AF9 Leukemia using
Primary Human HSPC in NOD/SCID mice
Role: Principal Investigator

Translational Research Initiative     07/01/07 – 06/30/08
CCHMC
Leukemia Fusion Gene Expression in Human HSPC:
A Novel Model for Therapeutic Testing
Role: Principal Investigator

Ohio Cancer Research Associates      08/01/06 – 07/31/08
Genetic screen for pathways cooperating with
AMLl-ETO in leukemia induction
Role: Principal Investigator

Current
R21 DK071103-01A1          5/01/06 – 04/30/09
NIH, NIDDK
RUNX-fusion Target Genes in Normal and Leukemic Hematopoiesis
Role: Principal Investigator

R01 CA118319-01             4/15/06 - 02/28/11
NIH, NCI
The Role of CBFβ-MYH11 in Acute Myeloid Leukemia
Role: Principal Investigator

ASH Scholar Award   (Junping Wei)        07/01/07 – 06/28/09
A Novel Model of MLL-AF9 Leukemia using
Primary Human HSPC in NOD/SCID mice
Role: Mentor

Pediatric Scientist Development Program (Ben Mizukawa)    07/01/08 – 06/30/10
Association of Medical School Pediatric Department Chairs
Characterization of Rac GTPases in Acute Myeloid Leukemia
(AML) and their Potential as Therapeutic Targets
Role: Co-Mentor

G&P Foundation for Cancer Research        06/01/08 – 5/31/11
Microenvironment and Flt3 Signaling in MLL Leukemia
Role: Principal Investigator

APRC Supplemental Award for R01 CA118319    07/01/08 – 06/30/10
NIH, NCI
Collaboration with Drs. Janet Rowley and Jianjun Chen
The Role of miRNAs in Cytogenetically Defined Acute Leukemia
Role: Principal Investigator

Hope Street Kids Fellowship (Kevin Link)            07/01/08 – 6/30/10
Targeting the FLT3 signaling pathway in MLL-AF9 leukemia
Role: Mentor

Pending:
R01 CA138223-01                 9/1/08 – 8/31/13
NIH, NCI
Identification, Characterization and Therapeutic
Targeting of Human Leukemia Stem Cells
Role: Principal Investigator

Publications, Most Recent

Connect to James Mulloy's publications on PubMed

Wei, J., Wunderlich, M., Fox, C., Alvarez, S., Cigudosa, J.C., Wilhelm, J.E., Zheng, Y., Cancelas, J.A., Gu, Y., Jansen, M., DiMartino, J.F. and Mulloy, J.C. Microenvironment Determines Lineage Fate in a Human Model of MLL-AF9 Leukemia. Cancer Cell. 2008 Jun;13(6):483-95.

Krejci, O., Wunderlich, M., Geiger, H., Schleimer, D., Jansen, M., Andreassen, P.R. and Mulloy, J.C. p53 signaling in response to increased DNA damage sensitizes AML1-ETO cells to stress-induced death. Blood. 111(4): 2190-2199, 2008

Wunderlich, M., Krejci, O., Wei, J., and Mulloy, J.C. Human CD34+ cells expressing the inv(16) fusion protein exhibit a myelomonocytic phenotype with greatly enhanced proliferative ability. Blood, 108(5)1690-1697, 2006.

Mulloy JC, Jankovic V, Wunderlich M, Delwel R, Cammenga J, Krejci O, Zhao H, Valk PJ, Lowenberg B, Nimer SD. AML1-ETO fusion protein up-regulates TRKA mRNA expression in human CD34+ cells, allowing nerve growth factor-induced expansion.Proc Natl Acad Sci U S A. 2005 Mar 15;102(11):4016-21.

Mulloy JC, Cammenga J, Berguido FJ, Wu K, Zhou P, Comenzo RL, Jhanwar S, Moore MA, Nimer SD. Maintaining the self-renewal and differentiation potential of human CD34+ hematopoietic cells using a single genetic element. Blood. 2003 Dec 15;102(13):4369-76.

Cammenga J, Mulloy JC, Berguido FJ, MacGrogan D, Viale A, Nimer SD. Induction of C/EBPalpha activity alters gene expression and differentiation of human CD34+ cells.Blood. 2003 Mar 15;101(6):2206-14.

Mulloy JC, Cammenga J, MacKenzie KL, Berguido FJ, Moore MA, Nimer SD. The AML1-ETO fusion protein promotes the expansion of human hematopoietic stem cells.Blood. 2002 Jan 1;99(1):15-23.