Dao Pan, PhD
Title
Assistant Professor
Email
Dao.Pan@cchmc.org
Phone
513-636-6315
Fax
513-636-1330
Credentials
PhD: University of Minnesota, Minneapolis, MN, 1997
MS: Peking Normal University, Beijing, China, 1991
BS: Peking Normal University, Beijing, China, 1988
Awards and Honors
Best Teaching Assistant Award, University of Minnesota, 1996
Keystone Symposia on Molecular and Cellular Biology Travel Award, National Institutes of Health Grant E6, April 1997
Research
Connect to Dao Pan's laboratory webpageResearch Grants and Contracts
Recent
Translational Research Initiative Award 07/01/04 – 06/30/05
CCHMC
Title: Preclinical Study on In Vitro Gene Therapy for MPS Type I
Role: Principal Investigator
R21 AI61703-01A1 04/01/05-03/31/08
NIH, NIAID
Title: In Vivo BM Stem Cell Gene Transfer: Implication for Treatment of MPS Type I
Role: Principal Investigator
U54 HL70871-01 (Joiner CH) 04/01/03-03/31/08
NIH NHLBI
Title: Cincinnati Comprehensive Sickle Center
Project 4: KCI Cotransporter Gene Expression
Role: Principal Investigator (09/01/05-03/31/08)
IMM72 (Lesinski, GB) 02/07-01/08
Ohio State University Cancer Center
Title: Inhibition of Suppressors of Cytokine Signaling (SOCS) Proteins with Lentiviral Vectors Expressing Short Hairpin RNAs (shRNA).
Role: Co-investigator.
Current
U54 HL070871 (Joiner) 04/01/08-03/31/13
NIH NHLBI
Title: Comprehensive Sickle Cell Center
Project 4: (Joiner--PI) Genetic Manipulation of Red Cell Volume Regulation
Role: Co-investigator
URC interdisciplinary grant award 07/01/08-06/30/09
University of Cincinnati
Title: Genetic Engineering for Delivering large-molecules across the blood-brain barrier
Role: Principal Investigator
R01 NS064330 09/30/08-8/31/13
NIH NINDS
Title: Genetic Therapy for CNS Manifestations in MPS I via BBB-Targeted Protein Delivery
Role: Principal Investigator
Pending
Drug Delivery Research Grant 12/01/2008-11/30/2010
Michael J. Fox Foundation
Title: Genetic Engineering for BBB-targeted Fusion-protein Delivery: Implication for Treatment of Parkinson's Disease
Role: Principal Investigator
R03 No number assigned (Qin –PI) 04/01/09-03/31/11
NIH NIDDK
Title: Development of a lentiviral vector carrying the human Menkes protein gene for potential gene therapy of human Menkes disease
Role: Co-investigator
Publications, Most Recent
Connect to Dao Pan's publications on PubMed
Worsham N, Scheusler T, von Kalle C and Pan D (2006): In vivo gene transfer
into adult stem cells in non-conditioned mice by in situ delivery of a
lentiviral vector. Mol Ther, 14(4): 514-524.
Wang D, Worsham DN and Pan D (2008). Co-expression of MGMTP140K and IDUA in
primary hepatocytes from MPS I mice enables efficient selection with
metabolic correction. Gene Medicine, 10: 249-259.
Pan D*, Sciascia A, Vorhees C and Williams M (2008). Progression of
behavioral deficits during development in mice with Hurler Syndrome. Brain
Research, 1188(1): 241-253. (*correspondent author)
Pan D (2008). In situ gene transfer into murine bone marrow stem cells. In:
Genetic modification of hematopoietic stem cells. Humana Press.
Pan D, Stroncek DF, Whitley CB. Improved gene transfer and normalized enzyme levels in primitive hematopoietic progenitors from patients with mucopolysaccharidosis type I using a bioreactor.J Gene Med. 2004 Dec;6(12):1293-303.
Hartung SD, Frandsen JL, Pan D, Koniar BL, Graupman P, Gunther R, Low WC, Whitley CB, McIvor RS. Correction of metabolic, craniofacial, and neurologic abnormalities in MPS I mice treated at birth with adeno-associated virus vector transducing the human alpha-L-iduronidase gene.Mol Ther. 2004 Jun;9(6):866-75.
Graupman P, Pan D, Konair B, Hartung S, McIvor S, Whitley C, Low W, Lam CH. Craniofacial abnormalities in a murine knock-out model of mucopolysaccharidosis I H: a computed tomography and anatomic study.J Craniofac Surg. 2004 May;15(3):392-8.
Presentations, Most Recent
DN Worsham, K Bohn, D Kuhel, DA Williams, C von Kalle, and D Pan. "In vivo adult stem cell gene therapy in mice by in situ delivery of a self-inactivating lentiviral vector using intrafemoral injection." Annual meeting of American Society of Gene Therapy, St. Louis, MO, June 1-5, 2005, Oral presentation, international.
D Pan, C von Kalle, DA Williams, DN Worsham, K Bohn, and C Lutz. In Vivo Bone Marrow Stem Cell Gene Transfer In Mice By In Situ Delivery Of A 3rd-Generation Lentiviral Vector Using Intrafemoral Injection. Annual meeting of American Society of Hematology, San Diego, CA, Dec. 4-7, 2004. Poster presentation, international.
D Pan, R Gunther, JL Frandsen, T Kafri, RS McIvor and CB Whitley. Systemic Delivery of a 3rd-generation Lentiviral Vector into Iduronidase-deficient Neonatal Mice with Observation of In Vivo Hematopoietic Stem Cell Gene Transfer. Annual meeting of American Society of Hematology, San Diego, CA, Dec. 6-9, 2003. Oral presentation, international.
D Pan, R Gunther, JL Frandsen, T Kafri, RS McIvor and CB Whitley. Systemic Delivery of a 3rd-generation Lentiviral Vector into Iduronidase-deficient Neonatal Mice with Observation of In Vivo Hematopoietic Stem Cell Gene Transfer. 2nd Annual Midwest Blood Club Symposium, Indianapolis, IN, May 1-2, 2004. Oral presentation, local.
CB Whitley, D Pan, SD Hartung, JS Frandsen, R Gunther, WC Low, SU Walkley, RS McIvor. Intravenous Administration of Lentiviral Vector, or Adeno-associated Virus (AAV) Vector, Produces Metabolic and Phenotypic Correction of Hurler Syndrome in Mice. Annual meeting of American Society of Human Genetics, Los Angeles, CA, Nov. 4-8, 2003. Poster presentation, international.
D Pan, R Gunther, JL Frandsen, T Kafri, RS McIvor and CB Whitley. Correction of Hurler syndrome by a single IV administration of lentiviral vector to newborn mice. Annual meeting of American Society of Gene Therapy, Washington DC, June, 2003. Poster presentation, international.
Professional Organization Memberships
American Society of Human Genetics
American Society of Gene Therapy
Books
Ge H and Pan D (1989).
Australian National Antarctic Research Exploration, China Ocean Press (edition).
Special Interests
Hematopoietic stem cells, Mesenchymal stem/progenitor cells, Gene therapy, Human genetics, Translational research, Lysosomal storage diseases
