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Theodosia A. Kalfa, MD, PhD

Theodosia A. Kalfa, MD, PhD

Title

Assistant Professor of Pediatrics

Appointment

Assistant Professor of Pediatrics, University of Cincinnati College of Medicine

Email

theodosia.kalfa@cchmc.org

Phone

513-636-0989

Fax

513-636-3549

Credentials

MD: Aristotle University Medical School, Thessaloniki, Greece, 1990.

PhD: Aristotle University Medical School, Thessaloniki, Greece, 1997.

Residency: Pediatrics, University Of North Carolina, Chapel Hill, NC, 1999.

Fellowship: Pediatric Hematology / Oncology, Duke University Medical Center, Durham, NC, 2003.

Certification:
Board Certified in Pediatric Hematology-Oncology (American Board of Pediatrics), 2004
Board Certified in Pediatrics (American Board of Pediatrics), 2000
ECFMG Certification, 1995

Licenses:
Full and Unrestricted Medical License (OH Medical Board), 2003-present
Full and Unrestricted Medical License (NC Medical Board), 2000-present
Full and Unrestricted license of Medical Practice in Greece, 1990-present

Awards and Honors

  • ASPHO Young Investigator Award, 2006
  • Fellow of The American Academy of Pediatrics (F.A.A.P.), 2005
  • Research Scholar, Cincinnati Comprehensive Sickle Cell Center, 2003-2008
  • Research Scholar, Pediatric Center for Gene Expression and Development, 2004-2006
  • Fellowship for AACR workshop on Molecular Biology in Clinical Oncology, 2003
  • Medical Diploma awarded with honors, (Summa Cum Laude).
  • Scholarship for academic excellence, awarded by the National Honor Foundation (IKY), Greece, every year while in Medical School.

Research

Connect to Theodosia Kalfa's laboratory website

  • Signaling in erythrocytes
  • Erythropoiesis
  • Sickle Cell disease
  • Endothelial cell biology

Research Grants and Contracts

NIH/NHLBI K08 HL088126 (Kalfa). Rac1 and Rac2 GTPases in erythroid function and differentiation. 2/11/2008-11/30/2012.

NIH/NHLBI U54 HL070871 (Joiner). Genetic Manipulation of Red Cell Volume Regulation. 4/01/2008-3/31/2013.

Publications, Most Recent

Connect to Theodosia Kalfa's publications on PubMed

A Diwan, AG Koesters, D Capella, H Geiger, TA Kalfa, GW Dorn, II (2008).  Targeting erythroblast-specific apoptosis in experimental anemia. Apoptosis. Aug;13(8): 1022-30.

D. Daria, M.D. Filippi, E.S. Knudsen, R. Faccio, Z. Li, T. Kalfa, H. Geiger (2008): The retinoblastoma tumor suppressor is a critical intrinsic regulator for hematopoietic stem and progenitor cells under stress. Blood. Feb 15;111(4): 1894-902. 

L. Yang, L. Wang, T.A. Kalfa, J.A. Cancelas, X. Shang, S. Pushkaran, J. Mo, D.A. Williams, Y. Zheng (2007): Cdc42 critically regulates the balance between myelopoiesis and erythropoiesis. Blood. 2007 Dec 1;110(12):3853-61.

Diwan, A.G. Koesters, A.M. Odley, S. Pushkaran, C.P. Baines, B.T. Spike, D. Daria, A.G. Jegga, H. Geiger, B.J. Aronow, J.D. Molkentin, K.F. Macleod, T.A. Kalfa, and G.W. Dorn, 11 (2007): Unrestrained erythroblast development in Nix mice reveals a mechanism for apoptotic modulation of erythropoiesis. Proc Natl Acad Sci USA. 2007 Apr 17; 104(16):6794-9.

T.A. Kalfa, Pushkaran S, Mohandas N, Hartwig JH, Fowler VM, Johnson JF, Joiner CH, Williams DA, Zheng Y. Rac GTPases regulate the morphology and deformability of the erythrocyte cytoskeleton. Blood. 2006 Dec 1;108(12):3637-45.

Kalfa TA, Zimmerman SA, Goodman BK, McDonald MT, Ware RE. Pelger-Huet anomaly in a child with 1q42.3-44 deletion. Pediatr Blood Cancer. 2005 Jul 8.

Gonzalez-Gronow M, Kalfa T, Johnson CE, Gawdi G, Pizzo SV. The voltage-dependent anion chennel (VDAC) is a receptor for plasminogen kringle 5 on human endothelial cells. J Biol Chem. 2003 Jul 18;278(29): 27312-8.

Presentations, Most Recent

 T.A. Kalfa, S. Pushkaran, J.A. Cancelas, M. Jansen, J.F. Johnson, K. Hebel, D.A. Williams, Y. Zheng (2006). Deficiency of Rac1 and Rac2 GTPases Perturbs Erythroid Proliferation and Differentiation but Not Enucleation. Podium presentation in the ASH meeting, December 8-13, 2006, Orlando, Florida.

T.A. Kalfa, S. Pushkaran, N. Mohandas, J.H. Hartwig, V.M. Fowler., J.F. Johnson, C.H. Joiner, D.A. Williams, Y. Zheng (2006): Rac GTPases in Erythroid Function and Differentiation. Podium presentation in the Red Cell Conference, November 3-4, 2006, New Haven, Connecticut.

T.A. Kalfa, S. Pushkaran, N. Mohandas, J.H. Hartwig, J.F. Johnson, C.H. Joiner, D.A. Williams, Y. Zheng. Rac GTPases Regulate the Morphology and Deformability of the Erythrocyte Cytoskeleton. Young Investigator Award presentation in the Presidential Symposium, ASPHO, 2006, San Francisco, California.

T.A. Kalfa, S. Pushkaran, N. Mohandas, J.H. Hartwig, J.F. Johnson, C.H. Joiner, D.A. Williams, Y. Zheng. Rac GTPases Regulate the Morphology and Deformability of the Erythrocyte Cytoskeleton. Podium presentation in the National Sickle Cell meeting, April 8-12, 2006, Memphis, Tennessee.

Kalfa TA, Pushkaran S, Mohandas N, Hartwig JH, Johnson JF, Joiner CH, Williams DA, Zheng Y. Erythrocyte Cytoskeletal Defects Induced in Mice by Deletion of Rac GTPases. Podium presentation in the National Sickle Cell meeting, April 10-13, 2005, Cincinnati, Ohio.

Kalfa TA, Wahl ML, Pizzo SV. Angiostatin and Kringle 5 Interact with Adhesion Complexes of the Human Microvascular Endothelial Cells and Induce Tyrosine Phosphorylation of Focal Adhesion Kinase. Poster presentation in the AACR New Directions in Angiogenesis Research Conference, Chicago, Illinois.

Kalfa TA, Pizzo SV. Angiostatin and kringle 5 interact with adhesion complexes of the human microvascular endothelial cells. Podium presentation in the Duke Pediatric Fellow Research Symposium, Durham, North Carolina.

Professional Organization Memberships

  • American Society of Pediatric Hematology-Oncology
  • American Society of Hematology
  • American Academy of Pediatrics
  • American Association for Cancer Research
  • Medical Association of Thessaloniki and Panhellenic Medical Association, Greece

Abstracts

T.A. Kalfa, S. Pushkaran, J.A. Cancelas, J.F. Johnson, D. Daria, H. Geiger, D.A. Williams, Y. Zheng (2007). Rac GTPases Regulate Erythropoiesis Both in the Early Steps of Differentiation and in Enucleation. Blood, 110 (1 I), p5 10a.

A. Diwan, A.G. Koesters, A.M. Odley, T.A. Kalfa, G.W. Dom (2007). Enhanced Erythroblast Mobilization in Nix-Deficient Mice Confers Resistance to Phenylhydrazine-Induced Anemia Despite Accelerated Erythrocyte Turnover. Blood, 110 (ll),p1068a.

D. Pan, T.A. Kalfa, D. Wang, M. Risinger, S. Crahle, P. Ciraolo, R.S. Franco, C.H. Joiner (2007). Change in Expressional Profile of KC1 Cotransporter Genes during Human Erythroid Differentiation. Blood, 110 (1 I), p509a.

T.A. Kalfa, S. Pushkaran, J.A. Cancelas, M. Jansen, J.F. Johnson, K. Hebel, D.A. Williams, Y. Zheng (2006). Deficiency of Rac1 and Rac2 GTPases Perturbs Erythroid Proliferation and Differentiation but Not Enucleation. Blood, 108 (11), p142a.

H. Geiger, M-D. Filippi, T.A. Kalfa, D. Daria (2006). A Critical Role for the Retinoblastoma Tumor Suppressor Gene in Hematopoietic Stem Cells. Blood, 108 (11), p720a.

Invited Speaker, St. Jude Children's Research Hospital. Hematology Research Seminar. Rac GTPases in erythroid biology. Memphis, TN. March 12, 2008.

Invited Speaker, Emergency Medicine Division Lecture. Emergency Management of Sickle Cell Disease Complications. Cincinnati, OH. May 16, 2007.

Invited Speaker, Dr. Mohandas Narla Laboratory. New York Blood Center. Rac GTPases in Erythroid Function and Differentiation. New York. April 9, 2007.

Invited Speaker, Respiratory therapy seminar. Cincinnati Children's Hospital Medical Center. Acute Chest Syndrome in children with Sickle Cell Disease. Cincinnati, OH. October 16, 2006.

Invited Speaker, Hoxworith Blood Center (SRAG Seminar). Erythrocyte Cytoskeletal Defects Induced in Mice by Deletion of Rac GTpases. Cincinnati, OH. June 24, 2005.