Qishen Pang Laboratory Research Interests
Research in the Pang Laboratory at Cincinnati Children's Hospital Medical Center focuses on the genetic syndrome Fanconi anemia (FA). Children with FA are often born with congenital anomalies, almost uniformly develop aplastic anemia, and have a high risk of developing leukemias and other cancers. FA has been considered an excellent model for hematopoietic failure and leukemic evolution. Eleven FA genes (FANCA, FANCB, FANCC, FANCD1/BRCA2, FANCD2, FANCE, FANCF, FANCG, FANCJ, FANCL and FANCM) corresponding to distinct FA complementation groups have been cloned, raising the potential of using gene transfer technology to replace the defective gene with a functional transgene of the appropriate complementation group using autologous stem cell transplantation. However, the pathophysiology of FA is not well understood, and the success of all treatments to date is limited.
The two major research interests of the Pang lab are apoptosis in FA cells and the role of nucleophosmin in normal hematopoiesis and leukemia.
For further information regarding Dr. Pang's research, please contact Dr. Qishen Pang at 513-636-1152. For additional information about the Division of Experimental Hematology, please contact Dr. David Williams at 513-636-0364. The Division of Experimental Hematology can be found in Room 6529 of Location R (Research Foundation Building).
