Fanconi anemia (FA)
Fanconi anemia (FA) is an autosomal recessive disease characterized by progressive bone marrow failure, variable congenital anomalies, and a predisposition to cancer. Cells from FA children are hypersensitive to DNA cross-linking agents such as mitomycin C (MMC) and diepoxybutane. This property currently serves as the diagnostic test for FA. Somatic cell fusion studies show that FA is genetically heterogeneous, with at least twelve complementation groups identified thus far. The genes encoding the groups A (FANCA), B (FANCB), C (FANCC), D1 (FANCD1/BRCA2), D2 (FANCD2), E (FANCE), F (FANCF), G (FANCG), J (FANCJ), L (FANCL),and M (FANCM) have been cloned. Mutations in the three FA genes, FANCA, FANCC and FANCG are found in approximately 90% of the FA patients worldwide. For more information on Fanconi anemia, please visit http://www.fanconi.org.
For further information regarding Dr. Pang's research, please contact Dr. Qishen Pang at 513-636-1152. For additional information about the Division of Experimental Hematology, please contact Dr. David Williams at 513-636-0364. The Division of Experimental Hematology can be found in Room 6529 of Location R (Research Foundation Building).
