Stem Cell Biology Program
Stem Cell Biology is an area of focus for the Division of Experimental Hematology and Cancer Biology at Cincinnati Children's Hospital Medical Center. Researchers know that the production of billions of blood cells each hour is required to maintain normal health. Although a great deal is understood about the factors controlling the final steps of this production leading to mature neutrophils or red blood cells, initial steps involving the survival, proliferation and differentiation of hematopoietic stem and progenitor cells are incompletely understood.
Stem Cell Journal Covers
Reprinted with permission from Science Volume 294, Number 5542, Issue of 19 October 2001. Copyright 2003 AAAS.
Reprinted with permission from Science Volume 302, Number 5644, Issue of 17 October 2003. Copyright 2003 AAAS.
In part, this is due to the infrequent number of the hematopoietic stem cells estimated to be 1 in 100,000 nucleated cells of the bone marrow. The Stem Cell Program of the Experimental Hematology and Cancer Biology Division is studying the biology of hematopoietic stem and progenitor cells to understand the factors regulating the normal proliferation and differentiation of these cells and determinants of abnormal differentiation and growth in leukemia.
New knowledge gained from these studies will have important implications for understanding pathological conditions associated with genetic diseases and for designing improved methods to grow and expand these cells in the laboratory.
To learn more about the interests of the researchers in stem cell biology laboratories at Cincinnati Children's visit the following lab sites:
Stem Cell Biology Program
Jose Cancelas, MD, PhD (Hoxworth Blood Center)- Program Leader
Marie-Dominique Filippi, PhD
Hartmut Geiger, PhD
Thomas Leemhuis, PhD (Hoxworth Blood Center)
Kurt Schibler, MD (Division of Neonatology)
David Williams, MD
() Indicates primary appointment
Contact Us
For additional information, please contact Dr. Yi Zheng, Division of Experimental Hematology and Cancer Biology, 513-636-0364. The Division of Experimental Hematology and Cancer Biology can be found in Room 7.205 of Location S (Research Foundation Building).
