Mobilization of Hematopoietic Stem Cells/Stem Cell Trafficking
Regulation of G-CSF induced mobilization of hematopoietic stem and progenitor cells into the periphery and subsequent harvesting of these cells by apheresis is now a routine clinical method to collect stem cells for transplantation purposes. Unfortunately, the molecular mechanisms that influence and regulate this mobilization are still poorly understood, which renders it very difficult to systematically improve mobilization regimens or find alternative approaches for people that fail to mobilize when the standard regimen is applied.
Due to its nature, mobilization is best studied in an animal system. Studying mobilization in the mouse serves as a useful surrogate system for the human setting, as it allows genetic modifications and complex experimental designs by taking advantage of inbred lines. The Geiger lab has a congenic mouse model available that was established based on a genetic screen. The lab will analyze the mobilization behavior of these animals in more detail and will finally identify the gene modifying mobilization and its regulation pathway.
Related Publications
Where possible, article titles are linked to an abstract of the article. Selected citations may also be linked to PDFs of the article available on a Journal's site. Depending on the Journal's publishing policy, you may need a subscription to download the PDF.
Geiger, H; True, JM; Grimes, B; Carroll, EJ; Fleischman, RA; Van Zant, G: Analysis of the hematopoietic potential of muscle-derived cells. Blood, 2002; 100:721-723.
Contact UsFor further information regarding Dr. Geiger's research, please contact
Dr. Hartmut Geiger at 513-636-1338. For additional information about the Division of Experimental Hematology, please contact
Dr. David Williams at 513-636-0364. The Division of Experimental Hematology can be found in Room 6529 of
Location R (Research Foundation Building).
