What's New

What's New in Experimental Hematology and Cancer Biology

What's New in Pictures

Transatlantic  Gene Therapy Retreat

The Transatlantic Gene Therapy Retreat was held  in London, England on October 3-4, 2007.  Organizer,  Dr. Waseem Qasim from UCL Institute of Child Health and Great Ormond Street Hospital for Children. (October, 2007)

2007 Williams' Laboratory Retreat

Williams' lab member enjoy the Cincinnati Reds game. (August, 2007)

This years Williams' Laboratory Retreat took place on August, 7th at the Great American Ball Park. (August, 2007)

14th Annual German Society of Gene Therapy (GSGT)

Members of the Experimental Hematology Faculty were intimately involved in the 14th Annual German Society of Gene Therapy (GSGT) held in July in Heidelberg, German. They are (l to r): Chris Baum(President of the GSGT), who co-hosted the meeting; David Williams, Director, Division of Experimental Hematology, who gave 3 invited talks, including a plenary talk; Christof V. Kalle, who organized the meeting; and Tom Moritz, who gave a presentation. The well-attended meeting featured 2-1/2 days of presentations and posters.

Dr. Baum is Director of the Department of Experimetnal Hematology at Hannover Medical School. Dr. Kalle is also Director of the National Center for Tumor Disease, NCT, Heidelberg. Dr. Mortiz is also a faculty member in the West German Cancer Institute in Essen, Germany. All three are also adjunct faulty of Pediatrics at Cincinnati Children's and maintain laboratories in Cincinnati. (July, 2007)

Red Cell Gordan Conference, Aussois, France

David Williams, presented work from Theodosia Kalfa, Yi Zheng and Gabriel Ghiaur at the Red Cell Gordon Conference in Aussois, France in late May. The work presented was mostly unpublished data on the role of Rac in erythrocyte development and in fetal stem cell migration. The data was very well received and generated much discussion. (May, 2007)

Cincinnati Children's Vector Production Facility

Members of the Vector Production Facility (D. Nordling, L. Reeves, W. Swaney, H. van der Loo) in the very first handoff of GMP vector (three vectors for the FDA-NTP project) produced at the Cincinnati Children's Vector Production Facility. (March, 2007)

OSUCCC (Ohio State University Comprehensive Cancer Center) Annual Scientific Retreat 2007

Attendees from Experimental Hematology and Hematology/Oncology enjoy lunch at the Ohio State University Comprehensive Cancer Center Annual Scientific Retreat held in Columbus, Ohio on February 23, 2007. (February, 2007)

The research scientists in the Division of Experimental Hematology and Cancer Biology regularly contribute many notable achievements both to the community of Cincinnati Children's Hospital Medical Center and to the world-wide scientific community.

The following accomplishments by Experimental Hematology and Cancer Biology faculty represent only a portion of the research taking place at Cincinnati Children's Research Foundation.

Recent Publications

February 2008

Bhatla, D., Gerbing, R. B., Alonzo, T. A., Mehta, P. A., Deal, K., Elliott, J., Meshinchi, S., Geiger, H., Perentesis, J. P., Lange, B. J. and Davies, S. M. "DNA repair polymorphisms and outcome of chemotherapy for acute myelogenous leukemia: a report from the Children's Oncology Group." Leukemia. 2008 Feb;22(2):265-72.

Daria, D., Filippi, M. D., Knudsen, E. S., Faccio, R., Li, Z., Kalfa, T. and Geiger, H. "The retinoblastoma tumor suppressor is a critical intrinsic regulator for hematopoietic stem and progenitor cells under stress." Blood. 2008 Feb 15;111(4):1894-902.

Eapen, M., Zhang, M. J., Devidas, M., Raetz, E., Barredo, J. C., Ritchey, A. K., Godder, K., Grupp, S., Lewis, V. A., Malloy, K., Carroll, W. L., Davies, S. M. and Camitta, B. M. "Outcomes after HLA-matched sibling transplantation or chemotherapy in children with acute lymphoblastic leukemia in a second remission after an isolated central nervous system relapse: a collaborative study of the Children's Oncology Group and the Center for International Blood and Marrow Transplant Research." Leukemia. 2008 Feb;22(2):281-6.

Gardner, S. L., Carreras, J., Boudreau, C., Camitta, B. M., Adams, R. H., Chen, A. R., Davies, S. M., Edwards, J. R., Grovas, A. C., Hale, G. A., Lazarus, H. M., Arora, M., Stiff, P. J. and Eapen, M. "Myeloablative therapy with autologous stem cell rescue for patients with Ewing sarcoma." Bone Marrow Transplant. 2008 Feb 4;

Hansen, M. D., Filipovich, A. H., Davies, S. M., Mehta, P., Bleesing, J., Jodele, S., Hayashi, R., Barnes, Y. and Shenoy, S. "Allogeneic hematopoietic cell transplantation (HCT) in Hurler's syndrome using a reduced intensity preparative regimen." Bone Marrow Transplant. 2008 Feb;41(4):349-53.

Krejci, O., Wunderlich, M., Geiger, H., Chou, F. S., Schleimer, D., Jansen, M., Andreassen, P. R. and Mulloy, J. C. "p53 signaling in response to increased DNA damage sensitizes AML1-ETO cells to stress-induced death." Blood. 2008 Feb 15;111(4):2190-9.

Mahller, Y. Y., Vaikunth, S. S., Ripberger, M. C., Baird, W. H., Saeki, Y., Cancelas, J. A., Crombleholme, T. M. and Cripe, T. P. "Tissue inhibitor of metalloproteinase-3 via oncolytic herpesvirus inhibits tumor growth and vascular progenitors." Cancer Res. 2008 Feb 15;68(4):1170-9.

Tan, W., Palmby, T. R., Gavard, J., Amornphimoltham, P., Zheng, Y. and Gutkind, J. S. "An essential role for Rac1 in endothelial cell function and vascular development." Faseb J. 2008 Feb 1;

Wu, J., Williams, J. P., Rizvi, T. A., Kordich, J. J., Witte, D., Meijer, D., Stemmer-Rachamimov, A. O., Cancelas, J. A. and Ratner, N. "Plexiform and dermal neurofibromas and pigmentation are caused by Nf1 loss in desert hedgehog-expressing cells." Cancer Cell. 2008 Feb;13(2):105-16.

Zychlinski, D., Schambach, A., Modlich, U., Maetzig, T., Meyer, J., Grassman, E., Mishra, A. and Baum, C. "Physiological Promoters Reduce the Genotoxic Risk of Integrating Gene Vectors." Mol Ther. 2008 Mar 4;

January 2008

Gordon, A., Kozin, E. D., Keswani, S. G., Vaikunth, S. S., Katz, A. B., Zoltick, P. W., Favata, M., Radu, A. P., Soslowsky, L. J., Herlyn, M. and Crombleholme, T. M. "Permissive environment in postnatal wounds induced by adenoviral-mediated overexpression of the anti-inflammatory cytokine interleukin-10 prevents scar formation." Wound Repair Regen. 2008 Jan 18;16(1):70-79.

Mehta, P. A. and Davies, S. M. "Allogeneic transplantation for childhood ALL." Bone Marrow Transplant. 2008 Jan;41(2):133-9.
Pan, D., Sciascia, A., 2nd, Vorhees, C. V. and Williams, M. T. "Progression of multiple behavioral deficits with various ages of onset in a murine model of Hurler syndrome." Brain Res. 2008 Jan 10;1188(241-53.

Wise-Draper, T. M. and Wells, S. I. "Papillomavirus E6 and E7 proteins and their cellular targets." Front Biosci. 2008 13(1003-17.

Grant Announcements

 

  • Clinton Joiner has been awarded a National Heart, Lung, and Blood Institute renewal award entitled, "Comprehensive Sickle Cell Center." (June, 2008)
  • Diagnostic Immunology Laboratory has been awarded a Health Resources and Services Administration (HRSA) award entitled, "Health Care and Other Facilities: Modernization of Flow Cyto metry in the Diagnostic Immunology Laboratories." (June, 2008)
  • Dao Pan has been awarded a University Research Council Interdisciplinary Grant entitled, "Genetic Engineering for Delivering Large-molecules Across the Blood-Brain Barrier". (June, 2008)
  • Jim Mulloy has been awarded a Gabrielle’s Angel Foundation for Cancer Research Award entitled, "Microenvironment and Flt3 Signaling in MLL Leukemia." (June, 2008)
  • Stella Davies has been awarded a University of Cincinnati Center for Environmental Genetics award entitled, "Genetic Epidemiology of Basal Cell Carcinoma in Childhood Cancer Survivors." (June, 2008)
  • Lisa Shook has been awarded a Health Resources and Services Administration (HRSA) award entitled, “Cincinnati Sickle Cell Newborn Screening Network.” (June, 2008)
  • Lars Wagner has been awarded a CancerFree Kids Pediatric Cancer Research Alliance award entitled, "Identification of Response Markers in Children Receiving Combination Therapy with Chemotherapy and Bevacizumab". (May, 2008)
  • Hartmut Geiger has been awarded a CancerFree Kids Pediatric Cancer Research Alliance award entitled, "The Role of the RB Protein in Leukemia Progression" (May, 2008)
  • Kai Li and John Perentesis have been awarded a CancerFree Kids Pediatric Cancer Research Alliance award entitled, "Personalized Neuroblastoma Cancer Signatures and Targeted Therapy". (May, 2008)
  • Timothy Cripe has been awarded a CancerFree Kids Pediatric Cancer Research Alliance award entitled, "Identifying and Targeting the Source of Neuroblastoma Metastasis". (May, 2008)
  • Andrew Browne has been awarded a CancerFree Kids Pediatric Cancer Research Alliance award entitled, “In vivo Targeted Delivery and Production of a Secretable Universal Cancer Biomarker and its Detection in the Blood by a Novel Continuous Sampling Microtechnology”.(May, 2008)
  • Dr. Gruppo has been awarded a clinical study agreement from GRIFOLS Biologicals, Inc. titled “A Postmarketing Observational Study to Assess the Efficacy and Safety of the Factor VIII/von Willebrand Factor Complex (Human), Alphanate®, in Preventing Excessive Bleeding During Surgery inSubjects with Congenital Type 3 von Willebrand Disease”. (May, 2008)
  • Maryam Fouladi has been awarded a Children's Oncology Phase I Consortium Award from the National Childhood Cancer Foundation for chairing the ADVL0416 clinical trial.(April, 2008)
  • Yi Zheng has been awarded as Co-Principal Investigator, a National Institute of Neurological Disorders and Stroke R01 entitled, "Rac GTPases in the Mammalian Brain Development." (March, 2008)
  • Hartmut Geiger has been awarded a National Institute of Diabetes and Digestive and Kidney Diseases grant entitled, "Young Stem Cell Potential in Aged Mice."  (March, 2008)
  • Debra Mayes has been awarded a National Multiple Sclerosis Society Postdoctoral Fellowship award entitled, "NF1 and Ras Activation on Oligodendrocyte Progenitor Dell Development and Myelination".   (February, 2008)
  • Hartmut Geiger has been awarded a R01 National Institutes of Health/ Slone-Kettering Institute for Cancer Research subaward entitled, "Oncogenic Events in Thyroid Neoplasia".  (February, 2008)
  • Theodosia Kalfa has been awarded a National Heart, Lung, and Blood Institute K08 award entitled, "Rac1 and Rac2 Guanosine Triphosphatases in Erythroid Function and Differentiation". (February, 2008)
  • Kevin Link has been awarded a two year appointment on an institutional training grant entitled, "Training Program in Cancer Therapeutics". (January, 2008)
  • Ruhikanta Meetei has been awarded a Fanconi Anemia research Fund award entitled, "Defining the Fanconi Anemia DNA Reparir Pathway by Protein Association Analysis". (October, 2007)
  • Timothy Cripe has been awared a laboraty contract form Cursade Laboratories Limited entitled, "Bridging studies of HSV1716 in support of BB-IND 13196". (Septmeber, 2007)
  • David Williams has earned a renewal of his National Institutes of Diabetes and Digestive and kidney Diseases award entitled, "Rac Protein in Hematopoietic Cell Survival and Function". (September, 2007)
  • Stella Davies has received a National Institutes of Health/St. Jude Children's Research Hospital subcontract entitled, "Antileukemic Effect of NK Cells in HCT for Pediatric AML." (August, 2007)
  • Nancy Ratner has earned a NIH R01 award entitled, "Schwann Cells in Neurofibromatosis Type 2 (NF2)". (August, 2007)
  • Nancy Ratner has received a University of Cincinnati Cancer Center award entitled "Compound Screening for NF1 Drug Discovery". (August, 2007)
  • Michael Milsom has received a National Blood Foundation award entitled, "Genetic Correction of the Fanconi Anemia Stem Cell Defect". (June, 2007)
  • Fukun Guo has received an American Heart Association Beginning Grant-in-Aid award entitled, "Genetic and Biochemical Evaluation of Rac1 GTPase Signaling Mechanism in Primary Cells" (May, 2007)
  • Ruhikanta Meetei has received a National Heart Lung, and Blood Institute award entitled, "Function and Regulation of FANCM in Fanconi Anemia". (May, 2007)
  • Jose Cancelas has received an Alex's Lemonade Stand Foundation for Childhood Cancer grant entitled, "Rac in P190-BCR-ABL-Induced Leukemia". (May, 2007)
  • Dr. Hartmut Geiger has received a CancerFree Kids Pediatric Cancer Research Alliance award entitled, "The Role of the RB Protein in the Progression of Lymphoblastic Leukemia". (March, 2007)
  • Trent Hummel, Research Fellow in Dr. Nancy Ratner's Laboratory, has received a Cincinnati Children's Hospital Medical Center Procter Scholar award. (March, 2007)
  • Dr. Jose Cancelas has received a Department of Defense (Army) grant entitled, "Inhibition of Rac GTPases in the Therapy of Chronic Myelogenous Leukemia." (March, 2007)
  • Dr. James Mulloy has received a Tranlsational Research Initiative Grant entitled, "MLL Fusion Genes in Acute Leukemia: A Novel Human Model for Therapeutic Testing" (March, 2007)
  • Dr. Christopher Baum has received a Translational Research Initiative Grant entitled, "Development of Natural Kill (NK) Cell Based Immunotherapeutic Interventation in a Murine leukemia Model" (March, 2007)
  • Dr. Yi Zheng has earned a National Cancer Institutes award entitled, "Rac GTPases as Targets in Lymphomagenesis". (February, 2007)
  • Dr. Paul Andreassen has received an Institutional American Cancer Society/University of Cincinnati award entitled, "BRIP1/FANCJ: Regulation and Relationship to Replication Stress." (January, 2007)
  • JunPing Wei, Research Associate in Dr. James Mulloy's laboratory, has received a Pfizer Global Research and Development scholarship to attend the symposium on Stem Cells and Cancer. (January, 2007)

Announcements

  • Drs. Qishen Pang and Christof von Kalle have recently been promoted within the Department of Pedicatrics.  Dr. Pang is now an Associate Professor of Pediatrics and Dr. Kalle is and Adjunct Research Professor. (August, 2007)
  • National Organization of Vascular Anomalies (NOVA) hosted the 5th Family Conference at Cincinnati Children's Hospital Medical Center, on April 13-14, 2007. The 2007 NOVA Family Conference featured opportunities for families to meet with specialist to discuss Rare Vasucular Tumors, Difficult Vascular Anomalies, KT PHACES and other vasucular anomaly related syndromes. Organizers of this event were Dr. Denise Adams, Associate Professor Hematology/Oncology at CCHMC, John DuBiel, NOVA President and Karla Hall, NOVA Executive Director. Download agenda here. (April, 2007)
  • Dr. Tim Cripe has been elected to serve a three-year term with the Council of the Society for Pediatric Research. (March, 2007)
  • Anjali Mishra, post-doctoral fellow in Dr. Christopher Baum's laboratory, was awarded Best Poster honors at the OSUCCC 9th Annual Comprehensive Cancer Center Scientific Meeting in Columbus held on February 23, 2007. Her poster was entitled: RhoH coordinates CD3-zeta mediated signaling pathways to control natural killer (NK) cell cytotoxicity by regulating actin and microtubule dynamics. The Annual Scientific Meeting included abstracts from 13 members of the Pediatric Oncology Program at Cincinnati Children's. The meeting theme was "Environment and Cancer: A Transdiciplinary Approach". (February, 2007)
  • Dr. Susanne Wells has been selected to receive the first ever "Schmidlapp Lecture" Award for 2007. This award is presented to "an outstanding woman faculty member who provides a stellar example of rapid and excellent progress on the academic pathway towards professorship". Since her arrival at Cincinnati Children's Hospital Medical Center, Dr. Wells has contributed in an outstanding fashion to both the intellectual environment of our program and to the mentorship and training of young people. She has rapidly attained significant National Institute of Health funding and is publishing regularly in excellent peer-reviewed journals. Importantly, she has made improving "life at Cincinnati Children's Medical Center" especially for post-doctoral fellows a personal focus. She has also already contributed in a significant fashion to the training and career development of many young people. (January, 2007)
  • Dr. Stella Davies has been selected to be a member of the American Pediatric Society. The Society honors physicians based on their contributions and advancement in the field of pediatrics. The physicians expertise in pediatric education and research are the primary focus in society nominations. (January, 2007)

Learn more about research activities in the Division of Experimental Hematology and Cancer Biology.

Contact Us

For additional information, please contact Dr. Yi Zheng,  Division of Experimental Hematology and Cancer Biology, at 513-636-0364. The Division of Experimental Hematology and Cancer Biology can be found in Room 7.205 of Location S (Research Foundation Building).