What's New in Experimental Hematology and Cancer Biology
The research scientists in the Division of Experimental Hematology and Cancer Biology regularly contribute many notable achievements both to the community of Cincinnati Children's Hospital Medical Center and to the world-wide scientific community.
The following accomplishments by Experimental Hematology and Cancer Biology faculty represent only a portion of the research taking place at Cincinnati Children's Research Foundation.
Announcements
- Drs. James Mulloy, Jose Cancelas and Susanne Wells have recently been promoted to Associate Professor with tenure, Dr. Han Van der Loo to Research Associate Professor, and Dr. Hartmut Geiger to Associate Professor, within the Department of Pediatrics, University of Cincinnati (October, 2008).
- Dr. Nancy Ratner has been honored to receive the Beatrice Lampkin Endowed Chair of Cancer Biology for her outstanding contribution to cancer research. The ceremony was held on December 18, 2008 at the Fifth Third Bank Auditorium, CCHMC.
- Yi Zheng, Ph.D., has accepted the appointment as Director of the Division of Experimental Hematology and Cancer Biology at CCRF, effective on January 9, 2009. Dr. Zheng also serves as an Associate Director of the incipient Cincinnati Children's Institute for Cancer and Blood Diseases and as an Associate Director for Basic Science in the Cincinnati Cancer Consortium. He has been serving in these roles on an interim basis for the last 16 months. Dr. Zheng has over 150 publications in leading, peer-reviewed journals, and currently has five different NIH R01 grants. He was named the Katherine Stewart Waters Professor of Pediatrics in 2006 in recognition of his outstanding scientific contributions (January 2009).
- The 7th Annual Midwest Blood Club will be hosted by Cincinnati Children's Hospital Medical Center on April 30 - May 1, 2009. The symposium, co-organized by Drs. Jim Mulloy and Lee Grimes from Division of Experimental Hematology, will include two exceptional plenary speakers, Dr. Jonathan Licht from Northwestern University and Dr. Dennis Hickstein from NIH. The meeting will present exciting overview of the blood-related research in the Midwest scientific community. The abstract submission deadline is March 7, 2009.
Recent Publications
March 2009
Wise-Draper TM, Mintz-Cole RA, Morris TA, Simpson DS, Wikenheiser-Brokamp KA, M. A. Currier MA, Cripe TP, Grosveld CG, Wells SI (2009). Overexpression of the cellular DEK protein promotes epithelial transformation in vitro and in vivo, Cancer Res, 69(5), 1792-9.
Pan D (2009). In situ (in vivo) gene transfer into murine bone marrow stem cells, Methods Mol Biol, 506, 159-69.
Morris LM, Lim FY, Livingston JC, Polzin WJ, Crombleholme TM (2009). High-risk fetal congenital pulmonary airway malformations have a variable response to steroids. J Pediatr Surg, 44(1), 60-5.
February 2009
Morris LM, Lim FY, Crombleholme TM (2009). Ex utero intrapartum treatment procedure: a peripartum management strategy in particularly challenging cases. J Pediatr, 154(1), 126-131 e3.
Mahller YY, Williams JP, Baird WH, Mitton B, Grossheim J, Saeki Y, Cancelas JA, Ratner N, Cripe TP (2009). Neuroblastoma cell lines contain pluripotent tumor initiating cells that are susceptible to a targeted oncolytic virus. PLoS ONE, 4(1), e4235.
Gu Y, Wills-Karp M, Henderson LB, Filippi MD, Vietor I, Grimes HL, Harley JB, Kilpatrick JR, et al. (2009). Identification of IFRD1 as a modifier gene for cystic fibrosis lung disease. Nature.
January 2009
Geiger, H., S. David, K. J. Nattamai and V. Jan (2009). Quantification of genomic mutations in murine hematopoietic cells. Methods Mol Biol. 506, 423-36.
Grant Announcements
- Jim Mulloy has been awarded a Department of Defense/Cleveland Clinic Foundation award entitled, “Next Generation DNMT-1 Depletion Therapy for Leukemia." (September 2009)
- Kevin Link has been awarded a CancerFree Kids award entitled, “Discovery of Novel Therapeutic Targets for the Treatment of Pediatric Leukemia." (August 2009)
- Nancy Ratner has been awarded a National Institute of Neurological Disorders and Stroke/Dartmouth College award entitled, “Identification of Drug Targets for NF1." (August 2009)
- Lisa Privette Vinnedge has been awarded a National Cancer Institute Fellowship award entitled, “The Role of DEK in Breast Cancer Development and Therapy.” (August 2009)
- Gang Huang has been awarded a Cincinnati Children’s Trustee award entitled, “Modeling Myelodysplastic Syndrome (MDS) in the Mouse." (August 2009)
- Joe Palumbo has been awarded an American Recovery and Reinvestment Act Administrative supplement on his NIH R01 entitled, “Mechanisms Linking Metastasis to Tumor Procoagulant and Innate Immunity.” (August 2009)
- Clinton Joiner has been awarded an NIH/New England Research Institute award entitled, “Sickle Cell Disease Clinical Research Network.” (August 2009)
- Fukun Guo has been awarded a Cincinnati Children’s Trustee award entitled, “Physiological Role of CDC42 in T Cell Polarity." (August 2009)
- Qishen Pang has been awarded an American Recovery and Reinvestment Act administrative supplement on his NIH R01 award entitled, “Role of RA Protein Complexes in Hematopoiesis.” (August 2009)
- Paul Andreassen has been awarded an American Recovery and Reinvestment Act administrative supplement on his NIH R01 award entitled, “FANCD2 Monoubiquitination in DNA Damage Responses.” (August 2009)
- Ruhi Meetei has been awarded an American Recovery and Reinvestment Act administrative supplement on his NIH R01 award entitled, “Function and Regulation of FANCM in Fanconi Anemia.” (August 2009)
- Jose Cancelas has been awarded an American Recovery and Reinvestment Act administrative supplement on his NIH R01 award entitled, “Rac GTPase Inhibition in Chronic Myelogenous Leukemia.” (August 2009)
- Jim Mulloy has been awarded a National Cancer Institute award entitled, “The Role of MLL-AF9 in Acute Myeloid Leukemia." (July 2009)
- Daniel Gonzalez-Nieto has been awarded a National Blood Foundation award for entitled, “Connexin-43 in the Hematopoietic Stem Cell Niche." (June 2009)
- Hartmut Geiger and Marnie Hall has been awarded a Translational Research Initiative entitled, “Increasing Stem Cell Mobilization by Erlontinib Treatment.” (June 2009)
- Han Van der Loo has been awarded a Translational Research Initiative entitled, “Novel Molecular Therapy Core.” (June 2009)
- Susanne Wells has been awarded a Translational Research Initiative entitled, “HPV Replication & Transformation in FA Squamous Cell Carcinomas.” (June 2009)
- Lee Grimes has been awarded a CancerFree Kids award entitled, “A Potential Cure for Acute Myeloid Leukemia.” (April 2009)
- Rachid Drissi has been awarded a CancerFree Kids award entitled, “Decreasing the Side Effects of Radiation Therapy for Cancer.” (April 2009)
- Maryam Fouladi has been awarded a CancerFree Kids award entitled, “Molecular Profiling of High-Grade Gliomas in Children.” (April 2009)
- Benjamin Mizukawa has been awarded a CancerFree Kids award entitled, “Chemosensitization of the Leukemic Stem Cell through Targeting its Interaction with the Marrow Niche.” (April 2009)
- Jose Cancelas has been awarded a National Heart, Lung, and Blood Institute award entitled, “Rac GTPase Inhibition in Chronic Myelogenous Leukemia." (April 2009)
- Yi Zheng has been awarded his National Institutes of Health competitive continuation entitled, “Rac GTPase-Specific Small Molecular Inhibitors.” (March 2009)
- Nancy Ratner has been awarded a Department of Defense award entitled, “Therapeutic Targets for Peripheral Nerve Tumors: NF1, NF2 and Schwannomatosis." (2009)
- Susanne Wells has been awarded a Fanconi Anemia Research Fund Award entitled, “HPV Replication and Transformation in FA Squamous Cell Carcinomas.” (February, 2009)
Learn more about research activities in the Division of Experimental Hematology and Cancer Biology.
Contact Us
For additional information, please contact Dr. Yi Zheng, Division of Experimental Hematology and Cancer Biology, at 513-636-0364. The Division of Experimental Hematology and Cancer Biology can be found in Room 7.205 of Location S (Research Foundation Building).
