Publications

2007 Publications

Publications

These publications may not include all publications authored by division members. Where possible, article titles are linked to an abstract of the article.

Abel, U., Deichmann, A., Bartholomae, C., Schwarzwaelder, K., Glimm, H., Howe, S., Thrasher, A., Garrigue, A., Hacein-Bey-Abina, S., Cavazzana-Calvo, M., Fischer, A., Jaeger, D., von Kalle, C. and Schmidt, M. "Real-time definition of non-randomness in the distribution of genomic events." PLoS ONE. 2007 2(e570.

Akbar, H., J. Kim, K. Funk, J. A. Cancelas, X. Shang, L. Chen, J. F. Johnson, D. A. Williams and Y. Zheng "Genetic and pharmacologic evidence that Rac1 GTPase is involved in regulation of platelet secretion and aggregation." J Thromb Haemost 2007. 5(8): 1747-55.

Arumugam, P. I., Scholes, J., Perelman, N., Xia, P., Yee, J. K. and Malik, P. "Improved Human beta-globin Expression from Self-inactivating Lentiviral Vectors Carrying the Chicken Hypersensitive Site-4 (cHS4) Insulator Element." Mol Ther. 2007 Oct;15(10):1863-71.

Bandarenko N, Cancelas J, Snyder EL, Hay SN, Rugg N, Corda T, Joines AD, Gormas JF, Pratt GP, Kowalsky R, Rose M, Rose L, Foley J, Popovsky MA. Successful in vivo recovery and extended storage of additive solution (AS)-5 red blood cells after deglycerolization and resuspension in AS-3 for 15 days with an automated closed system. Transfusion. 2007 Apr;47(4):680-686.

Baum, C. "Insertional mutagenesis in gene therapy and stem cell biology." Curr Opin Hematol. 2007 Jul;14(4):337-42.

Baum, C. "I could die for you: new prospects for suicide in gene therapy." Mol Ther. 2007 May;15(5):848-9.

Carey, B., Staudt, M. K., Bonaminio, D., van der Loo, J. C. and Trapnell, B. C. PU.1 redirects adenovirus to lysosomes in alveolar macrophages, uncoupling internalization from infection. J Immunol. 2007 Feb 15;178(4): 2440-7.

Chaturvedi, L. S., Marsh, H. M., Shang, X., Zheng, Y. and Basson, M. D. "Repetitive deformation activates focal adhesion kinase and ERK mitogenic signals in human Caco-2 intestinal epithelial cells through Src and Rac1." J Biol Chem. 2007 Jan 5;282(1):14-28.

Chen L, Liao G, Waclaw RR, Burns KA, Linquist D, Campbell K, Zheng Y, Kuan CY. Rac1 controls the formation of midline commissures and the competency of tangential migration in ventral telencephalic neurons. J Neurosci. 2007 Apr 4;27(14):3884-3893.

Cheng JC, Horwitz EM, Karsten SL, Shoemaker L, Kornblum HI, Malik P, Sakamoto KM. Report on the workshop "New Technologies in Stem Cell Research," Society for Pediatric Research, San Francisco, California, April 29, 2006. Stem Cells. 2007 Apr;25(4):1070-1088.

Ciccia, A., Ling, C., Coulthard, R., Yan, Z., Xue, Y., Meetei, A. R., Laghmani el, H., Joenje, H., McDonald, N., de Winter, J. P., Wang, W. and West, S. C. Identification of FAAP24, a Fanconi anemia core complex protein that interacts with FANCM. Mol Cell. 2007 Feb 9;25(3): 331-43.

Davies, S. M. "Subsequent malignant neoplasms in survivors of childhood cancer: Childhood Cancer Survivor Study (CCSS) studies." Pediatr Blood Cancer. 2007 Jun 15;48(7):727-30.

Deichmann, A., S. Hacein-Bey-Abina, M. Schmidt, A. Garrigue, M. H. Brugman, J. Hu, H. Glimm, G. Gyapay, B. Prum, C. C. Fraser, N. Fischer, K. Schwarzwaelder, M. L. Siegler, D. de Ridder, K. Pike-Overzet, S. J. Howe, A. J. Thrasher, G. Wagemaker, U. Abel, F. J. Staal, E. Delabesse, J. L. Villeval, B. Aronow, C. Hue, C. Prinz, M. Wissler, C. Klanke, J. Weissenbach, I. Alexander, A. Fischer, C. von Kalle and M. Cavazzana-Calvo "Vector integration is nonrandom and clustered and influences the fate of lymphopoiesis in SCID-X1 gene therapy." J Clin Invest 2007. 117(8): 2225-32.

Diwan A, Koesters AG, Odley AM, Pushkaran S, Baines CP, Spike BT, Daria D, Jegga AG, Geiger H, Aronow BJ, Molkentin JD, Macleod KF, Kalfa TA, Dorn GW, 2nd. Unrestrained erythroblast development in Nix-/- mice reveals a mechanism for apoptotic modulation of erythropoiesis. Proc Natl Acad Sci U S A. 2007 Apr 17;104(16):6794-6799.

Dumble M, Moore L, Chambers SM, Geiger H, Van Zant G, Goodell MA, Donehower LA. The impact of altered p53 dosage on hematopoietic stem cell dynamics during aging. Blood. 2007 Feb 15;109(4): 1736-42. 

Ebeling, P., Bach, P., Sorg, U., Schneider, A., Trarbach, T., Dilloo, D., Hanenberg, H., Niesert, S., Seeber, S., Moritz, T. and Flasshove, M. "Evaluation of different protocols for gene transfer into non-obese diabetes/severe combined immunodeficiency disease mouse repopulating cells." J Cancer Res Clin Oncol. 2007 Mar;133(3):199-209.

Farzin, A., Davies, S. M., Smith, F. O., Filipovich, A., Hansen, M., Auerbach, A. D. and Harris, R. E. "Matched sibling donor haematopoietic stem cell transplantation in Fanconi anaemia: an update of the Cincinnati Children's experience." Br J Haematol. 2007 Feb;136(4):633-40.

Filippi, M. D., Szczur, K., Harris, C. E. and Berclaz, P. Y. Rho GTPase Rac1 is critical for neutrophil migration into the lung. Blood. 2007 Feb 1;109(3): 1257-64.

Geiger H, Koehler A, Gunzer M. Stem cells, aging, niche, adhesion and Cdc42: a model for changes in cell-cell interactions and hematopoietic stem cell aging. Cell Cycle. 2007 Apr 15;6(8):884-887.

Guo, D., Tan, Y. C., Wang, D., Madhusoodanan, K. S., Zheng, Y., Maack, T., Zhang, J. J. and Huang, X. Y. "A Rac-cGMP signaling pathway." Cell. 2007 Jan 26;128(2):341-55.

Higashimoto, T., Urbinati, F., Perumbeti, A., Jiang, G., Zarzuela, A., Chang, L. J., Kohn, D. B. and Malik, P. "The woodchuck hepatitis virus post-transcriptional regulatory element reduces readthrough transcription from retroviral vectors." Gene Ther. 2007 Sep;14(17):1298-304.

Hochhausen N, Altmaier EM, McQuellon R, Davies SM, Papadopolous E, Carter S, Henslee-Downey J. Social support, optimism, and self-efficacy predict physical and emotional well-being after bone marrow transplantation. J Psychosoc Oncol. 2007 25(1):87-101.

Javazon, EH, Keswani, SG, Badillo, AT, Crombleholme, TM , Zoltick, PW, Radu, AP, Kozin, ED, Beggs, K Malik, AA and Flake, AW.  Enhanced epithelial gap closure and increased angiogenesis in wounds and diabetic mice treated with adult murine bone marrow stromal progenitor cells.  Wound Repair Regen, 2007 May-Jun;15(3): 350-9

Kelly PF, Radtke S, Kalle C, Balcik B, Bohn K, Mueller R, Schuesler T, Haren M, Reeves L, Cancelas JA, Leemhuis T, Harris R, Auerbach AD, Smith FO, Davies SM, Williams DA. Stem cell collection and gene transfer in fanconi anemia. Mol Ther. 2007 Jan;15(1):211-9.

Kline-Fath BM, Calvo-Garcia MA, O'hara SM, Crombleholme TM, Racadio JM. Twin-twin transfusion syndrome: cerebral ischemia is not the only fetal MR imaging finding. Pediatr Radiol. 2007 Jan;37(1):47-56. 

Kustikova OS, Geiger H, Li Z, Brugman MH, Chambers SM, Shaw CA, Pike-Overzet K, de Ridder D, Staal FJ, von Keudell G, Cornils K, Nattamai KJ, Modlich U, Wagemaker G, Goodell MA, Fehse B, Baum C. Retroviral vector insertion sites associated with dominant hematopoietic clones mark "stemness" pathways. Blood. 2007 Mar 1;109(5):1897-1907.

Lange, C., Li, Z., Fang, L., Baum, C. and Fehse, B. "CD34 modulates the trafficking behavior of hematopoietic cells in vivo." Stem Cells Dev. 2007 Apr;16(2):297-304.

Li, J., Sejas, D. P., Burma, S., Chen, D. J. and Pang, Q. "Nucleophosmin suppresses oncogene-induced apoptosis and senescence and enhances oncogenic cooperation in cells with genomic instability." Carcinogenesis. 2007 Jun;28(6):1163-70.

Li, Z., Kustikova, O. S., Kamino, K., Neumann, T., Rhein, M., Grassman, E., Fehse, B. and Baum, C. "Insertional Mutagenesis by Replication-Deficient Retroviral Vectors Encoding the Large T Oncogene." Ann N Y Acad Sci. 2007 Jun;1106(95-113.

Liang, Y., Jansen, M., Aronow, B., Geiger, H. and Van Zant, G. The quantitative trait gene latexin influences the size of the hematopoietic stem cell population in mice. Nat Genet. 2007 Feb;39(2): 178-88.

Ling C, Ishiai M, Ali AM, Medhurst AL, Neveling K, Kalb R, Yan Z, Xue Y, Oostra AB, Auerbach AD, Hoatlin ME, Schindler D, Joenje H, de Winter JP, Takata M, Meetei AR, Wang W. FAAP100 is essential for activation of the Fanconi anemia-associated DNA damage response pathway. Embo J. 2007 Apr 18;26(8):2104-2114.

Livingston, J. C., K. M. Malik, T. M. Crombleholme, F. Y. Lim and B. M. Sibai "Mirror syndrome: a novel approach to therapy with fetal peritoneal-amniotic shunt." Obstet Gynecol 2007. 110(2 Pt 2): 540-3.

Mahller, Y. Y., Vaikunth, S. S., Currier, M. A., Miller, S. J., Ripberger, M. C., Hsu, Y. H., Mehrian-Shai, R., Collins, M. H., Crombleholme, T. M., Ratner, N. and Cripe, T. P. Oncolytic HSV and Erlotinib Inhibit Tumor Growth and Angiogenesis in a Novel Malignant Peripheral Nerve Sheath Tumor Xenograft Model. Mol Ther. 2007 Feb;15(2): 279-286.

Mehta, P. A., Ileri, T., Harris, R. E., Williams, D. A., Mo, J., Smolarek, T., Auerbach, A. D., Kelly, P. and Davies, S. M. "Chemotherapy for myeloid malignancy in children with Fanconi anemia." Pediatr Blood Cancer. 2007 Jun 15;48(7):668-72.

Mehta PA, Eapen M, Klein JP, Gandham S, Elliott J, Zamzow T, Combs M, Aplenc R, MacMillan ML, Weisdorf DJ, Petersdorf E, Davies SM. Interleukin-1 alpha genotype and outcome of unrelated donor haematopoietic stem cell transplantation for chronic myeloid leukaemia. Br J Haematol. 2007 Apr;137(2):152-157.

Mehta PA, Davies SM. Pre-transplant minimal residual disease in children with acute lymphoblastic leukemia. Pediatr Blood Cancer. 2007 Jan;48(1):1-2.

Milsom, M. D. and D. A. Williams "Live and let die: in vivo selection of gene-modified hematopoietic stem cells via MGMT-mediated chemoprotection." DNA Repair (Amst) 2007. 6(8): 1210-21.

Parvadia, J. K., Keswani, S. G., Vaikunth, S., Maldonado, A. R., Marwan, A., Stehr, W., Erwin, C., Uzvolgyi, E., Warner, B. W., Yamano, S., Taichman, N. and Crombleholme, T. M. "Role of VEGF in small bowel adaptation after resection: the adaptive response is angiogenesis dependent." Am J Physiol Gastrointest Liver Physiol. 2007 Sep;293(3):G591-8.

Rao, A., Kamani, N., Filipovich, A., Lee, S. M., Davies, S. M., Dalal, J. and Shenoy, S. "Successful bone marrow transplantation for IPEX syndrome after reduced-intensity conditioning." Blood. 2007 Jan 1;109(1):383-5.

Rebmann, V., Schutt, P., Brandhorst, D., Opalka, B., Moritz, T., Nowrousian, M. R. and Grosse-Wilde, H. "Soluble MICA as an independent prognostic factor for the overall survival and progression-free survival of multiple myeloma patients." Clin Immunol. 2007 Apr;123(1):114-20.

Robert-Richard, E., Richard, E., Malik, P., Ged, C., de Verneuil, H. and Moreau-Gaudry, F. "Murine Retroviral but not Human Cellular Promoters Induce In Vivo Erythroid-specific Deregulation that can be Partially Prevented by Insulators." Mol Ther. 2007 Jan;15(1):173-82.

Schambach, A., Galla, M., Maetzig, T., Loew, R. and Baum, C. "Improving transcriptional termination of self-inactivating gamma-retroviral and lentiviral vectors." Mol Ther. 2007 Jun;15(6):1167-73.

Schwarzwaelder, K., S. J. Howe, M. Schmidt, M. H. Brugman, A. Deichmann, H. Glimm, S. Schmidt, C. Prinz, M. Wissler, D. J. King, F. Zhang, K. L. Parsley, K. C. Gilmour, J. Sinclair, J. Bayford, R. Peraj, K. Pike-Overzet, F. J. Staal, D. de Ridder, C. Kinnon, U. Abel, G. Wagemaker, H. B. Gaspar, A. J. Thrasher and C. von Kalle "Gammaretrovirus-mediated correction of SCID-X1 is associated with skewed vector integration site distribution in vivo." J Clin Invest 2007. 117(8): 2241-9.

Schutt, P., Passon, J., Ebeling, P., Welt, A., Muller, S., Metz, K., Moritz, T., Seeber, S. and Nowrousian, M. R. "Ifosfamide, etoposide, cytarabine, and dexamethasone as salvage treatment followed by high-dose cyclophosphamide, melphalan, and etoposide with autologous peripheral blood stem cell transplantation for relapsed or refractory lymphomas." Eur J Haematol. 2007 Feb;78(2):93-101.

Sejas DP, Rani R, Qiu Y, Zhang X, Fagerlie SR, Nakano H, Williams DA, Pang Q. Inflammatory reactive oxygen species-mediated hemopoietic suppression in Fancc-deficient mice. J Immunol. 2007 Apr 15;178(8):5277-5287.

Shang, X., Moon, S. Y. and Zheng, Y. p200 RhoGAP promotes cell proliferation by mediating cross-talk between Ras and Rho signaling pathways. J Biol Chem. 2007 March;282(12): 8801-11.

Spector, L. G., Davies, S. M., Robison, L. L., Hilden, J. M., Roesler, M. and Ross, J. A. Birth characteristics, maternal reproductive history, and the risk of infant leukemia: a report from the Children's Oncology Group. Cancer Epidemiol Biomarkers Prev. 2007 Jan;16(1): 128-34.

Su, Y., Davies, S., Davis, M., Lu, H., Giller, R., Krailo, M., Cai, Q., Robison, L. and Shu, X. O. "Expression of LINE-1 p40 protein in pediatric malignant germ cell tumors and its association with clinicopathological parameters: a report from the Children's Oncology Group." Cancer Lett. 2007 Mar 18;247(2):204-12.

Uchida, K., Beck, D. C., Yamamoto, T., Berclaz, P. Y., Abe, S., Staudt, M. K., Carey, B. C., Filippi, M. D., Wert, S. E., Denson, L. A., Puchalski, J. T., Hauck, D. M. and Trapnell, B. C. GM-CSF autoantibodies and neutrophil dysfunction in pulmonary alveolar proteinosis. N Engl J Med. 2007 Feb 8;356(6): 567-79.

van Lunzen, J., Glaunsinger, T., Stahmer, I., von Baehr, V., Baum, C., Schilz, A., Kuehlcke, K., Naundorf, S., Martinius, H., Hermann, F., Giroglou, T., Newrzela, S., Muller, I., Brauer, F., Brandenburg, G., Alexandrov, A. and von Laer, D. "Transfer of autologous gene-modified T cells in HIV-infected patients with advanced immunodeficiency and drug-resistant virus." Mol Ther. 2007 May;15(5):1024-33.

Wade, J.A., Hurley, C.K., Takemoto, S.K., Thompson, J., Davies S.M., Fuller T.C., Rodey, G., Confer, D.L., Noreen, H., Haagenson, M., Kan, F., Clein, J. Eapen, M., Spellman, S. and Kollman, C.  HLA mismatching within our outside of cross-reactive groups (CREGs) is associated with similar outcomes after unrelated hematopoietic stem cell transplantation.  Blood. 2007 May 1;109(9): 4064-70.

Wang, L., Yang, L., Debidda, M., Witte, D. and Zheng, Y. Cdc42 GTPase-activating protein deficiency promotes genomic instability and premature aging-like phenotypes. Proc Natl Acad Sci U S A. 2007 Jan 23;104(4): 1248-53.

Wang, L. and Zheng, Y. "Cell type-specific functions of Rho GTPases revealed by gene targeting in mice." Trends Cell Biol. 2007 Feb;17(2):58-64.

Will E, Bailey J, Schuesler T, Modlich U, Balcik B, Burzynski B, Witte D, Layh-Schmitt G, Rudolph C, Schlegelberger B, von Kalle C, Baum C, Sorrentino BP, Wagner LM, Kelly P, Reeves L, Williams DA. Importance of murine study design for testing toxicity of retroviral vectors in support of phase I trials. Mol Ther. 2007 Apr;15(4):782-791.

Williams, D. A. "A new mechanism of leukemia drug resistance?" N Engl J Med. 2007 Jul 5;357(1):77-8.

Williams, D. A. "ASGT Advises NIH on Funding of Gene Therapy Trials." Mol Ther. 2007 Jan;15(1):1-2.

Yang, C. H., Wei, L., Pfeffer, S. R., Du, Z., Murti, A., Valentine, W. J., Zheng, Y. and Pfeffer, L. M. "Identification of CXCL11 as a STAT3-dependent gene induced by IFN." J Immunol. 2007 Jan 15;178(2):986-92.

Yang L, Wang L, Geiger H, Cancelas JA, Mo J, Zheng  Y. Rho GTPase Cdc42 coordinates hematopoietic stem cell quiescence and niche interaction in the bone marrow. Proc Natl Acad Sci U S A. 2007 Mar 20;104(12):5091-5096.

Yang, L. and Zheng, Y. "Cdc42: a signal coordinator in hematopoietic stem cell maintenance." Cell Cycle. 2007 Jun 15;6(12):1445-50.

Zhang, X., Sejas, D.P., Qiu, Y., Williams, D.A. and Pang, Q. Inflammatory ROS promote and cooperate with the Fanconi anemia mutation ofr hematopoietic senescence. J Cell Sci, 2007 May 1;120(Pt 9): 1572-83.