Gastroenterology, Hepatology and Nutrition

Noah F. Shroyer, PhD

Appointment

Assistant Professor, University of Cincinnati College of Medicine

Email

noah.shroyer@cchmc.org

Phone

513-636-0129

Fax

513-636-5581

Credentials

BS: Microbiology and Biochemistry, Louisiana State University, Baton Rouge, LA, 1995.

PhD: Cell and Molecular Biology, Baylor College of Medicine, Houston, TX, 2001.

Postdoctoral: Molecular and Human Genetics, Baylor College of Medicine, Houston, TX, 2001-2005.

Position History

Assistant Professor, Department of Pediatrics, Baylor College of Medicine, 2005-2006.

Awards and Honors

NEI predoctoral training grant, 1996-2001

Claude W. Smith Fellowship Award, 1999

Best Oral Presentation, Cell and Molecular Biology Program, 2000

NIDDK postdoctoral training grant, 2002-2003

NRSA individual postdoctoral fellowship, 2003

Texas Gulf Coast Digestive Diseases Center Pilot / Feasibility award, 2005-2006

Poster of Distinction, Department of Pediatrics Fellows' Day, 2005

Research Scholars Award, AGA / Foundation for Digestive Health and Nutrition, 2005-2008

Travel Award, FASEB Conference "Innovations in GI Research and Therapy", 2005

NIDDK Mentored Research Scientist Development Award (K01), 2005-2009

Travel Award, AGA Conference “Stem Cells in GI Development Regeneration & Neoplasia”, 2006

Travel Award, UEGW/ASNEMGE Rising Stars program, 2006

Research

The Shroyer laboratory seeks to understand the molecular mechanisms of intestinal epithelial development, and how these pathways are impacted during diseases such as inflammatory bowel disease and colon cancer.

Three current aims include:

Characterizing the molecular pathway for intestinal epithelial differentiation. We are currently studying the targets of the transcription factors Atoh1/Math1, Gfi1, and SPDEF
Identify the role of the intestinal secretory cells in inflammatory bowel disease. We are manipulating the number of secretory cell types in the intestine to understand their contribution to inflammation and injury repair
Elucidating the roles for Atoh1, Gfi1, and SPDEF in regulating cell growth and cancer of the intestine and colon

For more information, visit the Shroyer Lab.

Research Grants and Contracts

National Institutes of Health, National Institute of Diabetes and Digestive and Kidney Diseases; Intestinal secretory lineage development and function; 09/2005-08/2009; Primary Investigator

National Institutes of Health, National Institute of Diabetes and Digestive and Kidney Diseases R03 DK084167; SPDEF in intestinal differentiation; 07/2009-06/2011; Primary Investigator

Children’s Hospital Research Foundation Trustee Award; ATOH1 as a tumor suppressor in colitis-associated cancer; 07/2009-06/2011; Primary Investigator

National Institutes of Health, National Cancer Institute R01 CA142826; The role of ATOH1 as a tumor suppressor in colorectal cancer; 01/2010-12/2014; Primary Investigator

Publications, Most Recent

Noah TK,Kazanjian A, Whitsett J, Shroyer NF. SAM Pointed Domain ETS Factor (SPDEF) regulates terminal differentiation and maturation of intestinal goblet cells.Experimental Cell Research 2010;316:452-65.

Bossuyt W*, Kazanjian A*, Aerts S, Leenaerts I, Claeys A, de Geest N, van Kelst S, de Hertogh G, Geboes K, Chuah M, Boivin GP, VandenDriessche T, Marynen P, Cools J, Shroyer NF†, Hassan BA†. Atonal homolog 1 (Atoh1) is a tumor suppressor gene.PLoS Biology 2009;7:e39. *Asterisk denotes equal contribution. † Dagger denotes two corresponding authors.

Kiesslich R, Goetz M, Angus EM, Hu Q, Guan Y, Potten C, Allen T, Neurath MF, Shroyer NF, Montrose MH, Watson AJM. Identification of epithelial gaps in human small and large intestine by confocal endomicroscopy: A translational study from mouse to man.Gastroenterology 2007;133:1769-78.

Shroyer NF*, Helmrath MA*, Wang VY-C*, Antalffy BA, Henning SJ, Zoghbi HY. Intestine specific ablation of Mouse atonal homolog 1 (Math1) reveals a role in cellular homeostasis.Gastroenterology 2007; 132:2478-88. *Asterisk denotes equal contribution.

Shroyer NF, Wallis Shultz D, Venken KJT, Bellen HJ, Zoghbi HY. Gfi1 functions downstream of Math1 to control intestinal secretory cell subtype allocation and differentiation.Genes and Development 2005;19:2412-7.

Presentations, Most Recent

Noah TK, Shroyer NF. (2009) SAM Pointed Domain Ets Factor (SPDEF) regulates terminal differentiation and maturation of intestinal goblet cells. FASEB Summer Research Conference “Gastrointestinal Tract XIII: Advances in the molecular and Cell Biology of the Intestinal Epithelium: Development, Inflammation, Host Defense, and Cancer”. Snowmass Village, Colorado. *Won Travel Award.

Shroyer NF, Kazanjian A, Noah TK, Vallance J, Zeisler B. (2009) The Notch-Atoh1 pathway controls proliferation and differentiation in intestinal progenitors and tumor cells. FASEB Summer Research Conference “Gastrointestinal Tract XIII: Advances in the molecular and Cell Biology of the Intestinal Epithelium: Development, Inflammation, Host Defense, and Cancer”. Snowmass Village, Colorado.

Kazanjian A, Burkart J, Shroyer NF. (2008) Atonal homolog 1 is a tumor suppressor in colorectal cancers. Digestive Diseases Week, San Diego, CA. *Selected for Oncology Section Plenary presentation.

Zeisler B, Chang I-Y, Shroyer NF. (2008) Atonal homolog 1 (Atoh1) regulates susceptibility to experimental colitis in mice. Digestive Diseases Week, San Diego, CA.

Kazanjian A, Burkart J, Shroyer NF. (2008) Atonal homolog 1 is a tumor suppressor in colorectal cancers. Keystone Meeting “Signaling Pathways in Cancer and Development”, Steamboat Springs, CO.

Kazanjian A, Burkart J, Shroyer NF. (2008) Atonal homolog 1 is a tumor suppressor in colorectal cancers. American Association for Cancer Research annual meeting, San Diego, CA.

Shroyer NF, Kazanjian A, Norris J, Henning SJ. (2007) Gene expression profiling of Gfi1 mutant adult intestinal crypts identifies a potential role in regulation of cell cycle within the intestine. Digestive Diseases Week, Washington, DC.

Shroyer NF, Norris J, Henning SJ, Zoghbi HY. (2007) Gene Expression profiling of Math1 mutant adult intestinal crypts identifies novel secretory lineage specific genes. Digestive Diseases Week, Washington, DC.