Gastroenterology, Hepatology and Nutrition

Rohit Kohli, MBBS, MS

Title

Attending Physician

Appointment

Assistant Professor

Email

rohit.kohli@cchmc.org

Phone

513-636-9776

Fax

513-636-5581

Credentials

MBBS: Armed Forces Medical College, Pune University, India.1993-1999

Residency: Metropolitan Hospital, New York Medical College, NY. 2000-2003

Certification: Pediatrics, 2004

Gastroenterology Fellowship: Children's Memorial Hospital, Northwestern University, IL. 2003-2006

MS: Clinical Investigation, School of Public Health, Northwestern University, IL. 2004-2006

Transplant Hepatology Fellowship: Children's Memorial Hospital, Northwestern University, IL. 2006-2007

Awards and Honors

George Ferry Young Investigator Award, 2007
American Association for the Study of Liver Diseases Transplant Hepatology Fellowship Award, 2006

Research

Obesity related fatty liver disease (non-alcoholic steatohepatitis)

Research Grants and Contracts

Child Health Research Career Development Award
10/01/2007-9/30/2009
NICHD K12 HD028827
Project Title: Pediatric Center for Gene Expression and Development

CDHNF
2007-2009
Role: Principal Investigator
Title: Effect of ileal transposition on nutrition associated hepatic steatosis

Publications, Most Recent

Kohli R, Pan X, Malladi P, Wainwright MS, Whitington PF. Mitochondrial reactive oxygen species signal hepatocyte steatosis by regulating the PI 3-kinase cell survival pathway.Journal of Biological Chemistry, 2007 Jul 20;282(29):21327-36.

Sahai A, Pan X, Paul R, Malladi P, Kohli R, Whitington PF. Roles of phosphatidylinositol 3-kinase and osteopontin in steatosis and aminotransferase release by hepatocytes treated with methionine-choline deficient medium.American Journal of Physiology, 2006 Jul; 291(1): G55-62.

Wainwright MS, Kohli R, Whitington PF, Chase D. Carnitine treatment inhibits increases in cerebral carnitine esters and glutamate detected by mass spectrometry following hypoxia-ischemia in newborn rats.Stroke 2006; 37; 524-530.

Kohli R, Harris DC and Whitington PF. Relative elevations of serum alanine and aspartate aminotransferase in muscular dystrophy.Journal of Pediatric Gastroenterology and Nutrition 2005; 41:121–124

Kohli R, Melin-Aldana H and Sentongo TA. Mesalamine-induced pneumonitis during therapy for chronic inflammatory bowel disease.Journal of Pediatric Gastroenterology and Nutrition, 2005 Oct; 41(4):479-482.

Kohli R, Li B U.K. Differential diagnosis of recurrent abdominal pain: new considerations.Pediatric Annals 2004 Feb; 33(2):113-22.

Presentations, Most Recent

Kohli R, Pan X, Malladi P, Wainwright MS, Whitington PF: Hepatocyte steatosis induced by nutritional perturbation is signaled by increased generation of mitochondrial reactive oxygen species. Presented at the American Association for the Study of Liver Diseases - Annual Scientific Meeting; 2006; Boston, MA.

Kohli R: Fatty liver disease & the metabolic syndrome: Survival mechanisms gone awry. Presented at the Children's Memorial Hospital- Grand Rounds; 2006; Chicago, IL.

Kohli R, Pan X, Malladi P, Wainwright MS, Whitington PF: Generation of mROS signals hepatocyte steatosis via phosphatidylinositol 3-kinase activation. Presented at the American Association for the Study of Liver Diseases - Single Topic Conference; 2006; Atlanta, GA.

Kohli R: Role of mitochondrial reactive oxygen species in NASH. Presented at the Chicago GI Epithelium & Mucosal Club Meeting; 2006; Chicago, IL.

Kohli R, Wainwright MS, Pan X, Malladi P, Whitington PF: Mitochondrial oxidant stress in experimental non-alcoholic Steatohepatitis. Presented at the North American Society of Pediatric Gastroenterology, Hepatology, and Nutrition Annual Meeting; 2005; Salt Lake City, UT.

Sahai A, Pan X, Brutus R, Malladi P, Kohli R, Whitington PF: Increased expression of Osteopontin induces hepatocyte injury but not steatosis in an in vitro model of nonalcoholic steatohepatitis. Presented at the American Gastroenterology Association: Digestive Diseases Week; 2005; Chicago, IL.

Kohli R, Besvedovsky A, Brown J, Neighbours K, Kelly S, Alonso EM: Results of a patient care initiative to reduce calcineurin inhibitor exposure in pediatric liver transplantation. Presented at the American Transplant Congress; 2005 Seattle, WA.

Kohli R: Effect of carnitine supplementation in a murine model of steatohepatitis. Presented at the Regional Pediatric GI Specialist Forum; 2004; Chicago, IL.