Cincinnati Children's Hospital Medical Center Logo

Bezerra Lab

Loading...

Pranavkumar Shivakumar, PhD

Title

Research Associate

Email

Pranav.Shivakumar@cchmc.org

Phone

513-636-3676

Fax

513-636-5581

Credentials

PhD: University of Bombay, Bombay, India, 2002.
M. Pharm.: University of Bombay, Bombay, India, 1997.

Honors/Awards

  • Travel award from the Division of Gastroenterology, Hepatology & Nutrition, CCHMC, Cincinnati, OH to present a talk at the at the 57th Annual Meeting of the American Association for the Study of Liver Diseases, October 27-31, 2006, Boston, Massachusetts.
  • Travel award from the National Institute of Diabetes & Digestive & Kidney Diseases, Bethesda, MD, for presenting a poster at the Research Workshop entitled, "Screening and Outcomes in Biliary Atresia", September 11-12, 2006, Bethesda Hyatt Hotel, Bethesda, MD.
  • First prize award for a poster presented at the 8th Annual Postdoctoral Fellows Research Forum, College of Medicine, University of Cincinnati, May 2006, Cincinnati, Ohio.
  • First prize award for a poster presented at the DDRDC Scientific Retreat and External Advisory Board Meeting, Cincinnati Children's Hospital Medical Center, January 2005, Cincinnati, Ohio.
  • Travel award from the Division of Gastroenterology, Hepatology & Nutrition, CCHMC, Cincinnati, OH to present a talk at the at the 55th Annual Meeting of the American Association for the Study of Liver Diseases, October 29-November 2, 2004, Boston, Massachusetts.
  • Travel award from Mean Johnson Nutritionals to present a talk at the 21st Neonatal Nutrition and Gastroenterology Symposium, December 9-12, 2004, Lago Mar Resort, Ft. Lauderdale, FL.
  • Travel award from the Division of Gastroenterology, Hepatology & Nutrition, CCHMC, Cincinnati, OH to present a talk at the 54th Annual Meeting of the American Association for the Study of Liver Diseases, October 24-28, 2003, Boston, Massachusetts.
  • Travel award from the Division of Gastroenterology, Hepatology & Nutrition, CCHMC, Cincinnati, OH to present a talk at the Pediatric Academic Societies'. Annual Meeting, May 3-6, 2003, Seattle, Washington.
  • University Grants Commission (UGC) Senior Research Fellowship for PhD.
  • University Grants Commission (UGC) Junior Research Fellowship for M. Pharm.
  • Indian Drug Manufacturers' Association - G. P. Nair award.
  • 36th Indian Pharmaceutical Congress Award presented at Karnataka University, Dharwad.
  • Karnatak University Gold medal for securing first rank B. Pharm.
  • College of Pharmacy, Jawaharlal Nehru Medical College, Belgaum, India Gold medal for securing first rank in B. Pharm. 
  • ABVM, Belgaum Branch Award for securing first rank to State in Dip. in Pharm.
  • Govt. of Karnataka, India, Drugs Control Dept. Gold medal for securing first rank to the State in Dip. in Pharm.

Current Professional Memberships

  • Member, Indian Pharmaceutical Association.
  • Life member, UDCT Alumni Association.

Publications, Most Recent

  • Shivakumar, P.; Sabla, G.E., Mohanty, S.; McNeal, M.; Ward, R.; Stringer, K.; Caldwell, C.; Chougnet, C.; Bezerra, J.A.: Effector role of neonatal CD8+ lymphocytes in epithelial injury and autoimmunity in experimental biliary atresia. Gastroenterology, 2006; 133: 268-277.
  • Mohanty, S.K.; Shivakumar, P.; Sabla, G.E., Bezerra, J.A.: Loss of interleukin-12-modifies the pro-inflammatory response but does not prevent duct obstruction in experimental biliary atresia. BMC Gastroenterology, 2006; 6:14.
  • Carvalho, E.; Shivakumar, P.; Sabla, G.E.; Aronow, B.; Bezerra, J.A: Analysis of the biliary transcriptome in experimental biliary atresia.  Gastroenterology, 2005; 129: 713-717.
  • Shivakumar, P.; Campbell, K.M.; Sabla, G.E.; Miethke, A.; Tiao, G.; McNeal, M.M.; Ward, R.L.; Bezerra, J.A.: Tropism and obstruction of extrahepatic bile ducts by lymphocytes are regulated by IFN-gamma in a mouse model of biliary atresia.  J Clin Invest, 2004; 114:322-329.
  • Shivakumar, P.; Bezerra, J.A.: Biliary atresia and Th1 function: Linking ymphocytes and bileducts.  Commentary on the article "Biliary Atresia is associated with CD4+ Th1 Cell-mediated Portal Tract Inflammation" by Mack C., et al. Pediatric Research, 2004; 56:9-10.
  • Zhang, D.Y.; Sabla, G.; Shivakumar, P.; Tiao, G.; Sokol, R.J.; Mack, C.; Shneider, B.L.; Aronow, B.; Bezerra, J.A.: Coordinate expression of regulatory genes differentiates embryonic and perinatal forms of biliary atresia.  Hepatology 2004; 39:954-962.
  • Shivakumar, P.; Kulkarni, V. M.: Insights into the selective inhibition of Candida albicans secreted aspartyl protease: A Docking Analysis Study. Bioorg. Med. Chem., 2002.
  • Shivakumar, P.; Yadav, V.; Gadad, A. K.; Kulkarni, V. M.: Internet: Altering how Chemistry is done. Ind. J. Pharm. Ed., 35(2), April-June, 2001. (This paper has received the IJPE Best Paper Award).

Find publications by Pranavkumar Shivakumar as listed by PubMed

Recent Presentations

  • Miethke A; Shivakumar P; and Bezerra JA.: The role of regulatory T cells in the pathogenesis of experimental biliary atresia. Poster presented at the Federation of Clinical Immunology Societies (FOCIS) 2007 Meeting, June 10, 2007, Sheraton San Diego Hotel & Marina, San Diego, CA.
  • Miethke A; Shivakumar P; and Bezerra JA.: The role of regulatory T cells in the pathogenesis of experimental biliary atresia. Poster presented at the Federation of Clinical Immunology Societies (FOCIS) Centers of Excellence, Trainee Satellite Symposium, June 7, 2007, Sheraton San Diego Hotel & Marina, San Diego, CA.
  • Miethke A; Shivakumar P; Sabla GE; and Bezerra JA.: The role of regulatory T cells in the pathogenesis of experimental biliary atresia. Poster presented at the Thomas Boat Lectures, March 21, 2007, Sabin Auditorium, Cincinnati Children's Hospital Medical Center, Cincinnati, OH.
  • Shivakumar P; Sabla GE; Chu A; and Bezerra JA.: NK lymphocytes direct cytotoxicity to cholangiocytes and injury of extrahepatic bile duct epithelium in experimental biliary atresia. Late Breaking Oral talk presented at the 57th Annual Meeting of the American Association for the Study of Liver Diseases, October 27-31, 2006, Boston, MA.
  • Shivakumar P; Sabla GE; Mohanty, SK; McNeal M; Ward R; and Bezerra JA.: Cytotoxic hepatic T-cells are associated with extrahepatic bile duct injury and obstruction in a murine model of experimental biliary atresia. Poster presented at the Research Workshop entitled, "Screening and Outcomes in Biliary Atresia," September 11-12, 2006, Bethesda Hyatt Hotel, Bethesda, MD.
  • Stringer KF; Shivakumar P; Sabla GE; Mohanty, SK; McNeal M; Ward R; Caldwell C; and Bezerra JA.: Identifying inflammatory cells associated with duct injury and obstruction in experimental biliary atresia. Oral talk presented at the Society for Pediatric Pathology Interim Meeting, October 5-8, 2006, Columbus Children's Hospital and Research Institute, Columbus, OH.
  • Shivakumar P; Sabla GE; Mohanty, SK; McNeal M; Ward R and Bezerra JA.: Cytotoxic lymphocytes mediate extrahepatic bile duct obstruction in a murine model of biliary atresia. Presented at the 8th Annual Postdoctoral Fellows Research Forum, College of Medicine, University of Cincinnati, May 2006, Cincinnati, OH (Poster was awarded the First Prize).
  • Shivakumar P and Bezerra JA.: Unraveling the molecular and cellular mechanisms involved in the pathogenesis of biliary atresia. Invited speaker to present at the 2nd International Symposium on Drug Discovery and Process Research, February 10-12, 2006, KLE's COP, J.N. Medical College Campus, Belgaum, India.
  • Shivakumar P; Sabla GE; Mohanty, SK; McNeal M; Ward R and Bezerra JA.: Functional synergism of lymphocytes in the pathogenesis of experimental biliary atresia. Presented at the Digestive Disease Research Development Center (DDRDC) Seminar Series, Division of Gastroenterology, Hepatology and Nutrition, October 27, 2005, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio.
  • Shivakumar P.; Sabla GE; Mohanty, SK; and Bezerra JA.: Effects of CD4+ and CD8+ T-cell depletion in a murine model of experimental biliary atresia. Presented at the Biliary Atresia Meeting, Divisions of Gastroenterology, Hepatology and Nutrition; Infectious Diseases and Molecular Immunology,  October 20, 2005, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio.
  • Mohanty SK; Shivakumar P; Sabla GE; and Bezerra JA.: Interleukin-12 independent obstruction of bile ducts in experimental biliary atresia. Poster accepted for presentation at the 56th Annual Meeting of the American Association for the Study of Liver Diseases (AASLD), November 11-15, 2005, San Francisco, CA.
  • Erickson, N; Shivakumar P; Sabla GE; Mohanty SK; Bezerra JA: Temporal-spatial regulation of apoptosis in experimental biliary atresia.  Oral presentation (Plenary session) at the 18th Annual Meeting of North American Society for Pediatric Gastroenterology, Hepatology & Nutrition (NASPGHAN), October 20-23, 2005, Salt Lake City, UT.
  • Miethke A; Shivakumar P; Sabla GE; McNeal M; Ward R and Bezerra JA.: Preclinical trial: inhibition of interferon gamma to restore lumenal patency in experimental biliary atresia. Poster presentated at the 24th Annual Edward L. Pratt Lectures, May 31, 2005, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio.
  • Shivakumar P; Mohanty, SK; Sabla GE;  McNeal M; Ward R and Bezerra JA.: Hepatic CD8+ lymphocytes regulate bile duct obstruction in experimental biliary atresia. Oral presentation at the 21st Neonatal Nutrition and Gastroenterology Symposium, December 9-12, 2004, Ft. Lauderdale, FL. 
  • Shivakumar P; Mohanty, SK; Sabla GE;  McNeal M; Ward R and Bezerra JA.: Hepatic CD8+ lymphocytes regulate bile duct obstruction in experimental biliary atresia. Oral presentation at the 55th Annual Meeting of the American Association of the Study of Liver Diseases, October 29-November 2, 2004, Boston, MA. 
  • Shivakumar P; Campbell KM; Sabla GE and Bezerra JA.: Interferon Gamma Mediates Obstruction of Extrahepatic Bile Ducts in a Murine Model of Biliary Atresia.  Presented at the Postdoctoral Fellows Research Forum, June 4, 2004, University of Cincinnati College of Medicine, Cincinnati, Ohio.
  • Shivakumar P.; Sabla G.; Bezerra JA.: Effect of CD8 cell depletion in a murine model of biliary atresia. Presented at the Biliary Atresia Meeting, Divisions of Gastroenterology, Hepatology & Nutrition, Infectious Diseases and Molecular Immunology, May 24, 2004, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio
  • Shivakumar P.; Sabla G.; Bezerra JA.: Effect of CD4 cell depletion in a murine model of biliary atresia. Presented at the Biliary Atresia Meeting, Divisions of Gastroenterology, Hepatology & Nutrition, Infectious Diseases and Molecular Immunology, April 20, 2004, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio
  • Miethke A.; Shivakumar P.; Bezerra JA.: Fibro-inflammatory obstruction of the bile duct is regulated by interferon gamma in the mouse model of biliary atresia.  Presented at the 23rd Annual Edward L. Pratt Lectures, May 25, 2004, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio.
  • Zhang DY.; Sabla G.; Shivakumar P.; Tiao G.; Sokol RJ.; Mack C.; Shneider BL.; Aronow B.; and Bezerra JA.: Coordinate Expression of Regulatory Genes Differentiates Embryonic and Perinatal Forms of Biliary Atresia.  Abstract submitted for presentation at the 2nd World Congress of Pediatric Gastroenterology, Hepatology and Nutrition, July 3-7, 2004, Paris, France.
  • Shivakumar P.; Sabla GE.; McNeal MM.; Ward RL.; Bezerra JA.: Functional Polarization of Lymphocytes Targets the Hepatobiliary System in a Murine Model of Biliary Atresia.  Poster presentation at the 54th Annual Meeting of the American Association for the Study of Liver Diseases, October 24-28, 2003, Boston, Massachusetts.
  • Shivakumar P.; Miethke A.; Sabla GE.; Bezerra JA.: Interferon-gamma Regulates Bile Duct Obstruction in Biliary Atresia.  AASLD Late Breaking Abstract Podium presentation at the 54th Annual Meeting of the American Association for the Study of Liver Diseases, October 24-28, 2003, Boston, Massachusetts.
  • Milkovich MA.; Zhang DY.; Sabla GE.; Shivakumar P.;  Bezerra JA.: Apoptosis in Biliary Atresia – Animal Model Studies.  Poster presentation at the University of Cincinnati Under-Graduate Research Program, August 14, 2003, College of Medicine, Cincinnati, Ohio.
  • Shivakumar P.; Sabla G.; Bezerra JA.: Murine model of biliary atresia: Studies on IFN-gamma deficient mice.  Presented at the Biliary Atresia Meeting, Divisions of Gastroenterology, Hepatology & Nutrition, Infectious Diseases and Molecular Immunology, July 22, 2003, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio
  • Shivakumar P.; Sabla GE.; Bezerra JA.: Induction of T-cell Polarization in a Murine Model of Biliary Atresia.  Presented at the Cincinnati Digestive Diseases Research Development Center (DDRDC), July 1, 2003, Division of Gastroenterology, Hepatology & Nutrition, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio.
  • Shivakumar P.; Campbell KM, Sabla GE and Bezerra JA.: Viral Tropism and Induction of T-cell Polarization in a Murine Model of Biliary Atresia.  Presented at the Postdoctoral Fellows Research Forum, May 8, 2003, University of Cincinnati College of Medicine, Cincinnati, Ohio.
  • Campbell KM.; Shivakumar P.; Sabla GE.; McNeal MM.; Ward RL.; Bezerra  JA.: Unique tropism of Rotavirus to Cholangiocytes in a Murine Model of Biliary Atresia. Presented by Shivakumar P., at the Pediatric Academic Societies' Annual Meeting, May 3-6, 2003, Seattle, Washington.
  • Shivakumar P.; Sabla G.; Bezerra JA.: Th1 and Th2 gene expression analyses in livers from patients with biliary atresia by real-time PCR.  Presented at the Biliary Atresia Meeting, Divisions of Gastroenterology, Hepatology & Nutrition, Infectious Diseases and Molecular Immunology, February 18, 2003, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio
  • Margarita Vaghina.; Shivakumar P.; Brian Steinmetz and Rashmi S. Hegde.: Studies on the oncoprotein Ski. Presented at the Division of Developmental Biology Retreat, October 17, 2002, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA.
  • Kulkarni, S. S.; Gokhale, V. M.; Shivakumar P.; and Kulkarni, V. M.: 3-D QSAR, Molecular Modeling, Synthesis and Screening of azoles as antifungal agents.  National Workshop on "Computer Aided Drug Design".  Bioinformatics Distributed Information Centre, University of Pune, 3–5 January 2001.

Special Interests

Dissecting molecular mechanisms and pathways involved in the pathogenesis of Biliary Atresia.

Patents

  1. Novel Antifungal Agents- Indian Patent filed jointly with FDC Limited, Mumbai, India, Application Number 125/MUM/2002.
  2. Novel Antifungal Agents- United States Patent Application 20050020653 (01/27/05) Class: 51439300 (USPTO).