Bezerra Lab

Vijay Saxena, PhD

Title

Research Associate

Email

vijay.saxena@cchmc.org

Phone

513-636-1869

Fax

513-636-5581

Credentials

M.Sc (Life Sciences): N Kaul Institute of Life Sciences, CSJM University, Kanpur, India 1993
PhD (Life Sciences): CSJM University, Kanpur, India. Work performed at the department of Microbiology, King George Medical College, Lucknow, India 1999

Awards

University Grants Commission (UGC) Junior Research Fellowship Fellowship award by Govt. of India for Research.

University Grants Commission (UGC) Senior Research Fellowship Fellowship award by Govt. of India for Master Research.

Publications, Most Recent

Saxena V., Magnusen A.F, Ondr J.K. and Katz J.D. The countervailing actions of myeloid and plasmacytoid dendritic cells control autoimmune diabetes. 2007(In revision for publication in J. Immunol.)
Singh R.R.,Saxena V , Zhang S., Li L., Finkelman F.D., Witte D.P., and Jacob C.O. Differential contribution of IL-4 and STAT6 versus STAT4 to the development of kidney disease in the NZM.2410 mice. J. Immunol, 2003. 170:4818-4825. (Highlighted in this issue section as top 10 papers of J. Immunol)
Saxena V.*, Yang J.Q.*, Chun T., Xu H., Wang C.R., Kaer L.V. and Singh R.R. Repeated α-galactosylceramide administration results in expansion of NKT cells and alleviates inflammatory dermatitis in MRL-lpr/lpr mice. J. Immunol.2003.171:4439-4436 (*equally contributed to the work) (Highlighted in this issue section as top 10 paper of clinical section of J. Immunol)
Saxena V.*, Lienesch D.W.*, Bommireddi R., Azhar M., Doetschman T. and Singh R.R. Dual role of immunoregulatory cytokine TGFβ in the pathogenesis of an immuno-inflammatory disease. 2007 (Manuscript in revision for publication in the J. Immunol) (*equally contributed to the work)
Bommireddi R., Saxena V., Ormsby I., Yin M., Babcock G F., Singh R. R. and Doetschman.T. Transforming growth factor beta-1 regulates lymphocyte homeostasis by preventing activation and subsequent apoptosis of peripheral lymphocytes. Journal of Immunology, 2003. 170:4612-4622.
Albuquerque D.A., Saxena V., Adams D.A., Boivin G.P., Brunner H., Witte D.P. and Singh R.R. An angiotensin converting enzyme inhibitor reduces systemic type 2 cytokine production and renal TGFβ expression: Implications for the treatment of chronic progressive lupus nephritis. Kidney. International. 2004. 65:846-859.
Singh R.R., Ebling F.M. Albuquerque D.A., Saxena V., Kumar V., Giannini E.H., Marion T., Finkelman F.D., and Hahn B.H. Induction of autoantibody production is limited in non-autoimmune mice. Journal of Immunology. 2002.169:587-594.
Pandey M.K., Saxena V and Agrawal S.D. Characterization of mixed lymphocyte reaction antibodies (MLR-Bf) in human pregnancy. BMC pregnancy and childbirth, 2003.3:2
Chaturvedi P., Saxena V., Dhawan R. and Chaturvedi U.C. Role of calcium in induction of dengue-virus specific helper T cells. Indian Journal of Experimental Biology. 1995. 33:809-815.

Find publications by Vijay Saxena as listed by PubMed

Recent Presentations

Saxena V., Ondr J.K., Magnusen A., Munn D and Katz J.D. Countervailing actions of myeloid and plasmacytoid dendritic cells control autoimmune diabetes. American Association of Immunologist meetings, May 20-24, 2007, Miami, FL.
Singh R.R. and Saxena V. Target organ damage in lupus: cytokines and growth factors contribute to progression of Kidney damage, which appears to be independent of autoantibodies. 7th international congress on SLE and related conditions. 2004, New York. NY.
Saxena V., Lienesch D.W., and Singh R.R. Mechanisms of chronic kidney damage in lupus: Role of type 2 cytokines and TGFβ. American association of immunologist meeting 2003, Denver, CO.
Yang J.Q., Saxena. V., Chun T., Xu H., Hong S., Van Kaer L., Wang C.R. and Singh R.R. Repeated α-galactosylceramicde administration results in quick homeostatic regeneration and expansion of NKT cells and alleviates dermatitis in MRL-lpr/lpr mice. FASEB meeting 2003, Denver, CO.
Saxena V. Finkelman F.D. and Singh R.R. Monitoring the kinetics of spontaneous cytokine responses in lupus-prone mice. FASEB meeting, 2003. Denver, CO.
Singh R.R.. Lienesch D.W, Witte D.P., Adams D.E., and Saxena V. Mechanisms of kidney damage in immuno-inflammatory diseases: looking beyond the autoimmunity. Journal of American Society of Nephrology. 2003, San Diego, CA.
Bommireddy R., Engle S. J., Saxena V., Ormsby I., Babcock G.F., and Doetschman T. TGFβ1 modulates Ca2+ dependent threshold levels of activation in T cells. FASEB meeting, 2003, Denver, CO.
Saxena V. and Singh R. R. IL-4 contributes to the development of glomerulosclerosis in lupus-prone NZM.2410 mice that spontaneously over-express IL-4. "New targets for the treatment of lupus" meeting at NIH, 2002, Bethesda, MD.
Saxena V., Witte D., Finkelman F. D., and Singh R.R. IL-4 contributes to the development of glomerulosclerosis, but not anti- DNA antibody
production in lupus. FASEB meeting, 2002, New Orleans, LA.
Bommireddi R., Saxena V., Ormsby I., Yin M., Babcock G. F., Singh R.R., and Doetschman T. TGF-β inhibits Ca2+-calcineurin mediated activation in thymocytes. FASEB Journal. 2002.15: A1060.
Saxena V., Singh N.K., Finkelman F. D., and Singh R.R. Spontaneous over-expression of IL-4 in mouse strain with lupus. FASEB J. 2001.Vol 15, No4 Part I, (271.2).
Singh R.R., Ebling F., Kumar V., Albuquerque D.A., Saxena V., Finkelman F.D., and Hahn B. Regulatory T cell limits activation of autoantibody production in non- autoimmune mice. FASEB Journal Vol. 15, No5 Part II, (951.32), March 2001.
Singh R.R., Chin J., Bui. T, Saxena V., Graham F., Gauldie J., and Braciak T. A. Recombinant Adenovirus- mediated cytokine gene transfer in murine lupus: In vivo cytokine regulation of antibody production. Proceeding of the Arthritis research conference, Alexandria, Virginia, August, 1999
Saxena V., Finkelman F.D., and Singh R.R. Characterizing intrinsic and self-peptide induced in vivo cytokine abnormalities in lupus prone NZM.2410 mice. Proceeding of the American college of rheumatology, Boston, MA 1999