Overview
Dr. Cohen focuses on host pathogen interactions and intestinal secretion. His current work is investigating the mechanism of E. coli heat stable enterotoxin and its receptor guanylyl cyclase-C (GC-C). This receptor also binds the endogenous mammalian peptides, guanylin and uroguanylin, that are produced in the intestine. He has generated two knock out strains of mice, one with a deletion of the guanylin gene and the other with a deletion of the uroguanylin gene. He is using these mice as well as GC-C knock out mice to identify other receptors for these peptides and to test the hypotheses that guanylin and uroguanylin are cytostatic and that removal of these ligands results in increased intestinal epithelial cell proliferation. In addition, he is testing the hypothesis that these peptides form a novel regulatory pathway to allow the intestine to communicate with the kidney to effect salt and water homeostasis.
Find Dr. Cohen's publications as listed by PubMed
Contact Us
Mitchell B. Cohen, MD
Director Gastroenterology, Hepatology and Nutrition
Professor of Pediatrics
Cincinnati Children's Hospital Medical Center
MLC 2010
3333 Burnet Avenue
Cincinnati, OH 45229-3039
Email mitchell.cohen@cchmc.org
Phone 513-636-3008
Fax 513-636-5581
