Overview
Dr. Rudolph focuses on intestinal crypt cell survival. Specifically, his work is directed towards the interrogation of the signal transduction pathways in which cAMP inhibits apoptosis using both cell culture and in vivo model systems. In intestinal cells, cAMP accumulation leads to multiple physiological effects, including chloride secretion and the inhibition of apoptosis. Dr. Rudolph has demonstrated that the survival effects of cAMP are through the activation of the ERK 1/2 cascade and is dependent upon the action of protein kinase A II (PKAII). He is dissecting this survival pathway using a cell culture model to explore the divergence of secretion and survival signaling mechanisms. Additionally, he is examining the physiological relevance of this pathway in a mouse model of intestinal epithelial apoptosis. The overall goal is to explore the mechanisms of crypt cell survival and design strategies that specifically protect the intestinal epithelium in times of stress without inducing unwanted side effects, such as fluid secretion and diarrhea.
Find Dr. Rudolph's publications as listed by PubMed
Julie Pratt is a Research Assitant IV in Dr. Rudolph's laboratory. She received her Masters degree in Biology from Ball State University. She is studying the role of cAMP in intestinal cell survival and signaling pathways of cell survival proteins.
julia.pratt@cchmc.org
Contact Us
Jeffrey A. Rudolph, MD
Assistant Professor of Pediatrics
Division of Gastroenterology, Hepatology, and Nutrition
Cincinnati Children's Hospital Medical Center
MLC 2010
3333 Burnet Avenue Cincinnati, OH 45229-3039
Email jeff.rudolph@cchmc.org
Phone 513-636-4415
Fax 513-636-7805
