Overview
The broad goal of our laboratory is to understand how regulation of intestinal gene expression influences the pathogenesis of enteric inflammation and cancer. Specifically, we are studying a transcription factor family called NF-κB and we have shown that it has a critically protective function in the intestine during acute inflammation. In addition, we are investigating the role of a cellular signaling protein called GSK-3β in coordinating the interplay between NF-κB and other transcription factors such as AP-1 and β-catenin. We have demonstrated that GSK-3 is important for proper expression of genes associated with the development of intestinal inflammation and cancer. As we continue this work, we hope to gain insight into the manner in which these proteins cooperate to dictate the development of inflammation and tumorigenesis of the intestine. Our work is currently funded by the Crohn’s and Colitis Foundation of America and the Foundation for Digestive Health and Nutrition.
Eleana Marie Harmel-Laws is a Research Assistant IV in Dr. Steinbrecher's laboratory. She received her Masters of Science degree from the University of Kentucky in 2004 for analysis of the effects of PCB exposure on liver function of freshwater fish.
Find Dr. Steinbrecher's publications as listed by PubMed
Contact Us
Kris A. Steinbrecher, PhD
Assistant Professor of Pediatrics
Division of Gastroenterology, Hepatology, and Nutrition
Cincinnati Children's Hospital Medical Center
MLC 2010
3333 Burnet Avenue Cincinnati, OH 45229-3039
Phone 513-636-4415
Fax 513-636-5581
