Gastroenterology, Hepatology and Nutrition

Recent Meeting Presentations

Members of the Division of Gastroenterology, Hepatology and Nutrition are active contributors to pediatric gastroenterology, hepatology and nutrition, both nationally and internationally.  Members of the division are making presentations at recent meetings. Names of division members are in bold type.

American Association for the Study of Liver Diseases Annual Meeting

Boston, MA, November 2-6, 2007

Invited Presentations

Balistreri WFGenes and Therapy for Cholestatic Liver Disease.

Balistreri WF, Suchy FJ:  Meet the Professor:  Cholestatic Disease in Children.

Bezerra J, Charlton MR:  Microarray Analysis.

Bezerra JPerioperative Steroids for Biliary Atresia.

Oral Presentations

Alonso EM, Neighbors K, Limbers C, Martz K, Webb T, Bucuvalas JC, Varni JW:  Health Related Quality of Life (HRQOL) in Pediatric Liver Transplant Recipients-Preliminary Results of the Studies of Pediatric Liver Transplantation (SPLIT) Functional Outcomes Group (FOG).

Matte U, Liu C, Miethke A, Mourya R, Kauffmann G, Moyer KD, Bull L, Spinner N, Thompson JR, Bezerra JHigh Throughput Sequence Analysis Identifies Individual and Combined Genetic Defects in Children with Syndromes of Intrahepatic Cholestasis.

Shneider B, Shepherd R, Magee J, Bucuvalas JC, Haber B, Karpen SJ, Rosenthal P, Schwarz KB, Suchy FJ, Whitington PF, Sokol RJ:  Discriminating Features of Biliary Atresia - A Prospective Multi-centered Analysis.

Poster Presentations

Haber B, Balistreri WF, Barton B, Gonzalez-Peralta RP, Goodman ZD, Jonas MM, Lobritto SJ, Mohan P, Molleston JP, Murray KF, Narkewicz M, Robuck PR, Rosenthal P, Schwarz KB:  HCV Autoimmunity in a U.S. Multi- Center Cohort of Treatment Naïve Children.

Narkewicz M, Dell Olio D, Karpen SJ, Krug S, Murray KF, Schwarz  KB, Yazigi N, S. Zhang S, Belle SH, Group F:  Pattern of Diagnostic Evaluation for the Causes of Pediatric Acute Liver Failure (PALF): Opportunities for Quality Improvement.

North American Society for Pediatric Gastroenterology, Hepatology and Nutrition Annual Meeting and Postgraduate Course

Salt Lake City, UT, October 25-28, 2007

Invited Speakers

Balistreri WClinical Science Year-in-Review.

Bezerra JLiver SNP Sets.

Bucuvalas JOverview of Quality Approaches.

Moyer S, Morgan PTransitioning the Pediatric Inflammatory Bowel Disease Patient to Adult Care.

Steinbrecher KA Protective Role for GSK-3β During Initiation of Inflammatory Bowel Disease.

Campbell Kα1-Antitrypsin as a Primary Disease and Risk Factor.

Campbell K, Rock M:  Screening Families: Cystic Fibrosis, α1-Antitrypsin Deficiency.

Moyer S, Colletti R, Yousseff N:  Meet the Professor:  Improving Quality Through Uniform Practices: Experiences in Inflammatory Bowel Disease & Lessons for Irritable Bowel Syndrome

Heubi J, Mack C:  Meet the Professor:  Heptotoxicity Drugs.

Cohen M, Henning S, Perman J, Sherman P:  Training Directors and Division Heads Meeting:  The Art and Science of Mentorship.

Oral Presentations

Miethke A, Matte U, Liu C, Balistreri W, Ryckman F, Bezerra JGene Mutations and Clinical Outcome After Biliary Diversion Surgery for Intractable Pruritus in Children with Intrahepatic Cholestasis.

Nylund CM, Noel J:  Bacterial Enteritis, A Risk Factor for Childhood Intussusceptions.

Poster Presentations

Boamah LM, Bohren J, Baker R, Moyer SAn Education Program for Adolescents with Inflammatory Bowel Disease.

Denson L, Bezold R, Moyer S, Ballard E, Carey R, Osuntokun B, Lippe B, Klein D:   A Randomized Trail of Growth Hormone (GH) in Active Crohn's Disease (CD).

Denson L, Dubinsky M, Kim M, Black D, Uchida K, Trapnell B, Kugathsan S: GM-CSF Auto-Antibodies and Disease Behavior in Crohn's Disease.

Greifer M, Kugathasan S, Hyams J, LeLeiko N, Mack D, Griffiths A, Crandall W, Bousvaros A, Evans J, Moyer S, Rosh J, Otley A, Pfefferkorn M, Oliva-Hemker M, Keljo D, Carvalho R, Kay M, Baldassano R, Lerer T, Markowitz J:  IBD Activity at Initial Diagnosis: Effect of Body Mass Index.

Han X, Jurickova I, Uchida K, Bonkowski E, Trapnell B, Denson L:  GM-CSF Regulates Mucosal Barrier Function and Susceptibility to Ileitis.

Heubi J, Boas SR, Blake K, Nasr SZ, Woo MS, Graff GR, Hardy KA, Amaro-Galvez R, Latino M, Lee C:  Safety and Efficacy of EUR-1008, A New Pancreatic Enzyme Product (PEP), in Cystic Fibrosis (CF) Patients with Exocrine Pancreatic Insufficiency (EPI).

Kappelman M, Margolis P, Moyer S, Cohen S, Gold B, Crandall W, Patel A, Mehta D, Milov D, Grunow J, Leibowitz I, Colletti R:  The Quality of Care in Pediatric Inflammatory Bowel Disease: Does the Chronic Care Model Work?

Kugathasan S, Dubinsky M, Denson L, Guthery S, Peterson N, Grant R, Lee J, Wang T, Griffiths A, Cucchiara S, Tomer G, Schork N, Broeckel U:  A Genome-Wide Association Study Identifies T Cell Lymphoma Breakpoint1 as a Novel Susceptibility Gene in Pediatric Onset Crohn's Disease.

Otley A, Markowitz J, Lerer T, Griffiths A, Moyer S, Leleiko N, Evans J, Mack D, Rosh J, Pfefferkorn M, Kugathasan S, Keljo D, Baldassano R, Kay M, Oliva-Hemker M, Bousvaros A, Crandall W, Carvalho R, Hyams J:   Budesonide Use at Diagnosis in a Large Multi-Center Prospective Pediatric Cohort.

Pentiuk S, Putnam P, Rothenberg MDissociation Between Symptoms and Histological Severity in Pediatric Eosinophilic Esophagitis.

Pfefferkorn M, Burke G, Griffiths A, Markowitz J, Rosh J, Mack D, Otley A, Kugathasan S, Evans J, Bousvaros A, Moyer S, Wyllie R, Oliva-Hemker M, Carvalho R, Crandall JW, Keljo D, Walters T, LeLeiko N, Hyams J:  Effect of Current Treatment Paradigms on Growth in Pediatric Crohn's Disease.

Samson CM, Bhatt DC, McLean BA, Kim SC:  Use of a Web-Based Data Registry to Show Improved IBD Patient Management.

Samson CM, Moyer MS, Denson LA, Kaul A, Putnam P, Tomer GDiagnostic Yield of Capsule Endoscopy and Impact on Clinical Management in a Pediatric Population.

Digestive Diseases Week

Washington, DC, May 19-23, 2007

Oral Presentations

Garin-Laflam MP, Steinbrecher KA, Rudolph JA, Mao J, Hawkins J, Cohen MB: Radioprotective Effect of Uroguanylin in Intestinal Epithelial Cells.

Kugathasan S, Dubinsky MC, Cucchiara S, Denson LA, Annese V, Tomer G, Kraemer R, Nievergelt C, Stephan D, Webster J, Jacob H, Schork NJ, Broeckel U: Genome Wide Association Study For a Narrow Pediatric Phenotype – Early Onset Colonic Crohn's Disease.

Poster Presentations

Han X, Jurickova I, Xu H, Carey R, Denson L: STAT5b Regulates Colon Epithelial Cell Survival in Crohn's Disease and Murine Colitis.

Hyams J, Kugathasan S, Lerer T, Griffiths AM, Otley A, Pfefferkorn MD, Moyer MS, Leleiko NS, Evans JS, Mack DR, Wyllie R, Rosh JR, Markowitz JF: Infliximab Use in Children with Crohn's Disease: Relationship to Immunomodulator Therapy.

Jurickova I, Carey R, Bonkowski E, Ballard E, Denson L: Peripheral Blood Granulocyte STAT3 Activation Correlates with Mucosal Inflammation in Inflammatory Bowel Disease.

Kaul A, Batra S: Colonic Caliber and Manometry Findings in Children with Chronic Constipation.

Keljo DJ, Markowitz JF, Langton C, Lerer T, Kugathasan S, Griffiths AM, Otley AR, Rosh JR, Pfefferkorn MD, Mack DR, Evans J, Bousvaros A, Moyer MS, Rothbaum R, Wyllie R, Oliva-Hemker MM, Mezoff AG, Leleiko NS, Crandall WV, Hyams JS:  Fistulae in Pediatric Crohn's Disease: Frequency and Time Course.

Kugathasan S, Uchida K, Mallin D, Han X, Jurickova I, Trapnell B, Denson L: Anti-GM-CSF Auto-Antibodies Regulate Neutrophil Function and Correlate With Inflammatory Bowel Disease Phenotype.

Markowitz J, Crandall WV, Evans JS, Kugathasan S, Leleiko NS, Mack DR, Moyer MS, Oliva-Hemker MM, Otley A, Pfefferkorn MD, Rosh JR, Langton C, Hyams J: Anti-cBir1 is Helpful in Characterizing Children with Indeterminate Colitis.

Markowitz J, Rosh JR, Pfefferkorn MD, Otley A, Oliva-Hemker MM, Moyer MS, Mack DR, LeLeiko NS, Kugathasan S, Evans JS, Crandall WV, Langton C, Hyams J: Young Children with Crohn's Disease Demonstrate Different Serologic Profiles Than Those Who Present at an Older Age.

Moy LC, Markowitz J, Mack DR, Evans JS, Leleiko NS, Kugathasan S, Pfefferkorn MD, Rosh JR, Otley A, Crandall WV, Griffiths AM, Oliva-Hemker MM, Keljo DJ, Mezoff AG, Moyer MS, Bousvaros A, Wyllie R, Langton C, Hyams J: Clinical Outcome of Ulcerative Colitis (UC) in Children: A Prospective 3 Year Follow-up from Diagnosis.

Rudolph JA, Pratt J, Cohen MB: Cyclic-AMP Inhibition of Apoptosis in the Murine Jejunal Crypt.

Santoro KB, O'Flaherty T, Kaul A: Pureed Diet via Gastrostomy Tube Reduces Retching and Gagging and Promotes Increased Oral Intake.

Shroyer NF, Norris J, Henning SJ, Zoghbi HY: Gene Expression Profiling of Math1-mutant Adult Intestinal Crypts Identifies Novel Secretory Lineage Specific Genes.

Shroyer NF, Norris J, Kazanjian A, Henning SJ: Gene Expression Profiling of Gfi1-mutant Adult Intestinal Crypts Identifies Secretory Lineage Genes and a Potential Role for Gfi1 in Regulation of Cell Cycle Within the Intestine.

Steinbrecher KA, Harmel-Laws EM, Mao J, Meier K, Cohen MB: Proliferative Response to Guanylate Cyclase C Activation via PKC/ERK in a Colorectal Cancer Cell Line.

Session Chair

Bezerra JA: Current Controversies in Biliary Atresia.

Pediatric Academic Societies Annual Meeting

Toronto, Ontario, Canada, May 5-8, 2007

Poster Symposium

Matarazzo NP, Meinzen-Derr JK, Rodriguez G, Louden E, Falcone RA, Levitt MA, Peña A, Bates MD: Beyond VACTERL: Different Types of Anorectal Malformations Are Associated with Different Combinations of Other Congenital Anomalies.

Poster Presentations

Boamah L, Yi M, Moyer SAre We Effectively Educating Adolescents with Inflammatory Bowel Disease?

Yi MS, Britto MT, Moyer MS, Sherman SN, Kotagal UR, Putnam FW, Carlton-Ford SL, Tsevat J: Utilities of Adolescents with Inflammatory Bowel Disease.

Yi MS, Webb TS, Tsevat J, Goldenhar LM, Moyer MS, Canfield DL, Wise RE, Britto MT: Expectations from Future Healthcare among Adolescents with Inflammatory Bowel Disease.

Session Chair

Bates MD: Gastroenterology II.