Hong Du, PhD
Title
Assistant Professor
Appointment
Assistant Professor of Pediatrics
Email
hong.du@cchmc.org
Phone
513-636-7136
Fax
513-636-3486
Credentials
PhD: Biochemistry, City University of New York, NY, 1989.
Postdoctoral Fellow: The Rockefeller University, 1989-1992, the Laboratory of Biochemistry and Molecular Biology.
Research
Molecular pathophysiology of Wolman Disease and cholesteryl ester storage disease:
To evaluate the role of lysosomal acid lipase in cholesterol and fat acid metabolism in vivo using gene targeted mouse model; to study the pathogenesis of lysosomal acid lipase deficiency to Wolman disease and cholesteryl ester storage disease; and to test the gene therapy in this animal model.
Publications, Most Recent
Du H, Heur M, Witte DP, Ameis D, Grabowski GA: Lysosomal acid lipase deficiency: correction of lipid storage by adenovirus-mediated gene transfer in mice.Hum Gene Ther 2002, 13:1361-1372.
Hakala JK, Oksjoki R, Laine P, Du H, Grabowski GA, Kovanen PT, Pentikainen MO: Lysosomal enzymes are released from cultured human macrophages, hydrolyze LDL in vitro, and are present extracellularly in human atherosclerotic lesions.Arterioscler Thromb Vasc Biol 2003, 23:1430-1436.
Yang L, Naltner A, Kreiner A, Yan D, Cowen A, Du H, Yan C: An enhancer region determines hSP-B gene expression in bronchiolar and ATII epithelial cells in transgenic mice. Am J Physiol Lung Cell Mol Physiol 2003, 284:L481-488.
Du H, Schiavi S, Wan N, Levine M, Witte DP, Grabowski GA: Reduction of atherosclerotic plaques by lysosomal acid lipase supplementation. Arterioscler Thromb Vasc Biol 2004, 24:147-154.
Sugii S, Reid PC, Ohgami N, Du H, Chang TY: Distinct endosomal compartments in early trafficking of low density lipoprotein-derived cholesterol.J Biol Chem 2003, 278:27180-27189.
Yang, L., Yan, C., and Du, H. Peroxisome proliferator-activated receptor g and ligands inhibit SP-B gene expression in the lung.J Biol. Chem. 2003, 278:36841-36847.
Lian X, Yan C, Yang L, Xu Y, Du H: Lysosomal acid lipase deficiency causes respiratory inflammation and destruction in the lung.Am J Physiol Lung Cell Mol Physiol 2004, 286:L801-807.
Du H, Dardzinski BJ, O'Brien K J, Donnelly LF: MRI of fat distribution in a mouse model of lysosomal Acid lipase deficiency. AJR Am J Roentgenol 2005, 184:658-662.
Du H, Grabowski GA: Lysosomal acid lipase and atherosclerosis.Curr Opin Lipidol 2004, 15:539-544.
Recent Presentations
Du, H.: Adenovirus-mediated Gene Therapy for Wolman and cholesteryl ester storage disease. Invited Speaker in the Department of Pediatrics, Children's Hospital in Chongquing, July 23, 2002; Chongquing, P.R. China.
Du, H.: Adenovirus-mediated Gene Therapy to treat Wolman disease and atherosclerosis. Invited speaker in The Cell and Molecular Therapy Nidus Group Montly Seminar Series. Division of Experimental Hematology, Cincinnati Children's Hospital Medical Center, September 18, 2002; Cincinnati, OH.
Du, H.: Enzyme therapy for lysosomal acid lipase deficiency in the mouse model. 52nd Annual Meeting. The American Society of Human Genetics, October 18, 2002; Baltimore, Maryland.
Du, H.: Adenovirus-mediated gene therapy to treat atherosclerosis in a mouse model. Invited speaker in "Molecular and Gene Therapy Retreat". Organized by Division of Experimental Hematology, Cincinnati Children's Hospital Medical Center. Marriott Conference Center, December 11, 2002; Covington, KY.
Du, H.: Differential Therapeutic effect of lysosomal acid lipase produced in Pichia pastoris and CHO cells. Society for Pediatrics Pathology Fall Meeting. Albert B. Sabin Education Center. Cincinnati Children's Hospital Medical Center, October 17, 2003; Cincinnati, OH.
Du, H.: Lysosomal Acid lipase: more than just break done the lipids in the body. Invited speaker in DDRDC research meeting. Cincinnati Children's Hospital Medical Center, May 4, 2004; Cincinnati, OH.
Du, H.: Role of lysosomal acid lipase in lipodystrophy. Obesity Research Collaborative Workshop. Cincinnati Children's Hospital Medical Center and University of Cincinnati College of Medicine. August 6, 2004; Cincinnati, OH.
Related Areas
This person works in these other areas at Cincinnati Children's Hospital Medical Center:
