Human Genetics

Lisa J. Martin, PhD

Appointment

Research Associate Professor, University of Cincinnati College of Medicine

Email

lisa.martin@cchmc.org

Phone

513-636-1244

Fax

513-636-7509

Bio

Dr. Martin is an internationally recognized genetic epidemiologist. She has performed genetic analysis of complex traits for over 10 years and has published over 60 peer-reviewed publications (nearly half of which she is first or senior author) in prestigious journals including Nature Genetics, PNAS, and Diabetes. During her post-doctoral training, she received the James V. Neel Young Investigator Award for work on obesity genetics. At Cincinnati Children's, she received the Charlotte R. Schmidlapp Award for being an outstanding female investigator. Her research skills are further reflected in her grant funding; she held a PI on American Diabetes Association Career Development Award and has worked as co-I on multiple grants focusing on the genetics of complex traits.

At Cincinnati Children's, Dr. Martin provides statistical support for human genetic studies. She has been involved in family and population based genetic analyses by collaborating with numerous investigators. As part of this support, Dr. Martin assists in project planning, writing the statistical section of grant proposals, and assists with writing research papers. Recently, Dr. Martin has studied methodological considerations of genome wide association (GWA), especially how to reduce the number of false positives in the context of a million statistical tests1, 2. This work served as a basis for performing GWA at Cincinnati Children's. Indeed, she has designed several GWA studies under consideration for funding.

Credentials

PhD: (with Honors) University of Kansas, Lawrence KS, 1999

Post-doctoral fellow: Southwest Foundation for Biomedical Research, San Antonio TX, 2002

Position History

2008-present Research Associate Professor, Department of Pediatrics, Cincinnati Children’s Hospital Medical Center

2002- 2008 Research Assistant Professor, Department of Pediatrics, Cincinnati Children’s Hospital Medical Center

Awards and Honors

Who's Who in Medicine and Healthcare (4th edition, 2002-2003)
IGES James V. Neel Young Investigator Award 2000

Research

The genetics of normal variation, obesity, reproduction, and asthma.

Research Grants and Contracts

PI: Hinton R
Source: NIH
Dates: 07/01/06 – 06/30/11
Title: The genetic and developmental basis of Pediatric Aortic Valve Disease Pathogenesis
Summary: The goal of this project is to identify the underlying etiology of hypo plastic left heart syndrome.
Role: Co-Investigator

PI: Benson W
Source: NIH
Dates: 06/01/06 – 05/31/08
Title: Genetic mechanisms of cardiac diseases in the young
Summary: The goal of this project is to clarify the genetic architecture of cardiac disease development in the young.
Role: Co-Investigator

PI: Benson W
Source: NIH/NHLBI
Dates: 1/01/04 – 12/31/09
Title: Molecular mechanisms of valve development and disease
Summary: This study is project 1 of a larger SCCOR grant designed to examine valvular heart disease. Project 1's goal is to identify genes responsible for the development of two types of valvular heart disease: bicusipid aortic valve (BAV) and Ebstein anomaly. This study will perform a genome screen on families ascertained for BAV and refine a previously identified linkage for Ebstein anomaly.
Role: Co-investigator Project 1

PI Molloy C
Autism Speaks #1984 07/01/07 – 06/30/10
Autism Speaks
Genome wide association study of autism characterized by developmental regression
The goal of this project is to identify autism susceptibility variants using genome wide association.

PI Woo D
R01 NS36695 07/01/08 – 06/30/13
NIH
Genetic and Environmental Risk Factors for Hemorrhagic Stroke
The goal of this project is to use genome wide association to identify novel genetic variants associated with stroke.

Publications, Most Recent

Hinton RB, Martin LJ, Rame-Gowda S, Tabangin ME, Cripe LH, Benson DW. Hypoplastic Left Heart Syndrome Links to Chromosomes 10q and 6q and isGenetically Related to Bicuspid Aortic Valve. JACC 2009;53(12):1065-71.

Woo JG, Guerrero ML, Altaye M, Ruiz-Palacios GM, Martin LJ, Dubert-Ferrandon A, Newburg DS, Morrow AL. Human milk adiponectin is associated with infant growth in two independent cohorts. Breastfeeding Medicine. 2009;4(2):101-109.

Zhu H-Y, Wang S-W, Martin LJ, Liu L, Li Y-H, Chen R, Wang L, Zhang M-L, Benson DW. The role of mitochondrial genome in essential hypertension in a Chinese Han population. European Journal of Human Genetics. 2009;17(11): 1501-06.

Tabangin ME, Woo JG, Martin LJ. The effect of minor allele frequency (MAF) on likelihood of obtaining false positives. BMC Proceedings 2009;15:3 Suppl 7:S41.

Comuzzie AG, Martin LJ, Cole S, Rogers J, Cox L, Mahaney MC, Blangero J, VandeBerg JL. A QTL for fat free mass in baboons localizes to a region homologous to human chromosome 6. Obes Res

North KE, Martin LJ. The Importance of Gene-Environment Interaction: Implications for Social Scientists. Sociological Methods & Research 2008; 37(2):164-200.

Saunders CL, ChiodiniBD, ShamP, LewisCM, CollierDA and the BMI-GSMA consortium (Abkevich V, AdeyemoAA, de AndradeM, AryaR, BerensonGS, BlangeroJ, BoreckiIB, ChagnonYC, ChenW, ComuzzieAG, DengH-W, DuggiralaR, FeitosaMF, FroguelP, HansonRL, HebebrandJ, Huezo-DiasP, KissebahAH, LiW, LukeA, Martin LJ,NashM, ÖhmanM, PalmerLJ, Peltonen L, Perola M, Price RA, Redline S, Srinivasan SR, Stern MP, StoneS, WijmengaC, Wu X. Meta-analysis of genome-wide linkage studies in body mass index and obesity. Obesity. 2007;15(9):2263-2275.

Woo JG, Sun G, Haverbusch M, Indugula S, Martin LJ, Broderick JP, Deka R, Woo D. Quality Assessment of Buccal versus Blood Genomic DNA using the Affymetrix 500K GeneChip. BMC Genetics. 2007;8:79.

Martin LJ, Woo JG, Avery C, Chen HS, North KE. Multiple Testing in the Genomics Era: Findings from GAW 15. Genetic Epidemiology. 2007; 31 (Suppl. 1): S124-S131.

Comuzzie AG, Tejero ME, Funahashi T, Martin LJ, Kisseban A, Takahashi M, Kihara S, Tanaka S, Rainwater DL, MatsuzawaY, MacCluer JW, and Blangero J. The genes influencing adiponectin levels also influence risk factors for the metabolic syndrome and type 2 diabetes. Human Biology. 2007;79(2):191-200.

Tabangin ME, Woo JG, Liu C, Nick T, Martin LJ. Comparison of FDR for Genome-wide and Fine Mapping Regions. BMC Proceedings. 2007;1 Suppl 1:S148.

Hinton RB Jr, Martin LJ, Tabangin ME, Mazwi M, Cripe LH, Benson DW. Hypoplastic Left Heart Syndrome is Heritable and a Severe Form of Valve Malformation. JAAC. 2007;50:1590-5.

Cordell HJ, de Andrade M, Babron M-C, Bartlett CW, Beyene J, Bickeböller H, Culverhouse R, Cupples A, Daw EW, Dupuis J, Falk CT, Ghosh S, Goddard KA, Goode EL, Hauser ER, Martin LJ, Martinez M, North KE, Saccone NL, Schmidt S, Tapper W, Thomas D, Tritchler D, Vieland VJ, Wijsman EM, Wilcox MA, Witte JS, Yang Q, Ziegler A, Almasy L, MacCluer JW. Genetic Analysis Workshop 15: Gene Expression Analysis and Approaches to Detecting Multiple Functional Loci. BMC Proceedings. 2007;1 Suppl 1:S1.

Broeckel U, Hengstenberg C, Mayer B, Maresso K, Gaudet D, Seda S, Tremblay J, Holmer S, Erdmann J, Glöckner G, Harrison H, Martin LJ, Williams JT, Schmitz G, Riegger GAJ, Jacob HJ, Hamet P, Schunkert H. A Locus on Chromosome 10 Influences C-Reactive Protein Levels in Two Independent Populations. Human Genetics. 2007;122(1):95-102.

Martin LJ, Ramachandran V, Cripe LH, Hinton RB, Andelfinger G, Tabangin M, Shooner K, Keddache M, Benson DW. Evidence in Favor of Linkage to Human Chromosomal Regions 18q, 5q and 13q for Bicuspid Aortic Valve and Associated Cardiovascular Malformations. Human Genetics. 2007;121(2):275-84.

Crimmins N, Martin LJ. Polymorphisms in Adiponectin Receptor Genes ADIPOR1 and ADIPOR2 and Insulin Resistance. Obesity Reviews. 2007;8:419-23.

Crimmins NA, Woo JG, Kausha RD, Deka R, Dolan LM, Martin LJ. Adiponectin Receptor 1 Gene (ADIPOR1) Variation is Associated with Decreased HOMA-IR Conditional on Adiposity in African-Americans. Obesity. 2007;15(8):1903-7.

Crimmins NA, Dolan LM, Martin LJ, Bean JA, Daniels SR, Lawson ML, Goodman E, Woo JG. Longitudinal Changes in Adolescent BMI During 3 Years of Follow-up. Journal of Pediatrics. 2007l;151:383-7.

Professional Organization Memberships

Teaching

Guest lecturer, Cardiovascular Epidemiology, Department of Environmental Health, University of Cincinnati, Cincinnati, OH 45229, Spring 2003 & 2006
Responsibilities: Presentation of review of the genetics of obesity and cardiovascular disease.

Guest Lecturer, “Obesity, Cardiovascular Disease, Diabetes: The Adiponectin connection” 3rd Biennial genetics Program for Nursing Faculty’s Genetics Update Workshop, Multiple Perspectives on the Applications of Genetic Advances, Summer 2004

Guest Lecturer, Genetics of Complex Disease (26-BE-868), Department of Environmental Health, University of Cincinnati, Cincinnati, OH 45229, Fall 2004, 2006, 2008:
Responsibilities: Presentation of mapping of complex traits.

Lecturer, Human Genetics, College of Medicine, University of Cincinnati, Cincinnati, OH 45229, Spring 2003 – 2006, Fall 2008
Responsibilities: Presentation of Mendelian inheritance, population genetics and linkage analysis, and writing examination questions.