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Human Genetics

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Daniel R. Prows, PhD

Appointment

Associate Professor, University of Cincinnati College of Medicine

Email

daniel.prows@cchmc.org

Phone

513-636-5440

Fax

513-636-3486

Credentials

  • BS Biology: University of Cincinnati, 1983
  • BS Pharmacy: University of Cincinnati, 1988 (practicing pharmacist from 1988 to 2001; OH licensure)
  • PhD Pharmaceutical Sciences: University of Cincinnati, 1995

Position History

  • 1995–1998, Post-doctoral Fellow; Division of Toxicology, Department of Environmental Health, University of Cincinnati
  • 1998–2000, Research Associate; Division of Toxicology, Department of Environmental Health, University of Cincinnati
  • 2000–2001, Research Assistant Professor; Division of Toxicology, Department of Environmental Health, University of Cincinnati
  • 2001–2004, Research Assistant Professor; Children’s Hospital Medical Center, Division of Human Genetics, Department of Pediatrics, University of Cincinnati (1° appt.)
  • 2001–2004, Research Assistant Professor; Division of Toxicology, Department of Environmental Health, University of Cincinnati (2° appt.)
  • 2004–2009, Assistant Professor, Children’s Hospital Medical Center, Division of Human Genetics, Department of Pediatrics, University of Cincinnati
  • 2009–present, Associate Professor, Children’s Hospital Medical Center, Division of Human Genetics, Department of Pediatrics, University of Cincinnati

Awards and Honors

  • 1980, Member of the National German Honor Society
  • 1982, Undergraduate University Scholarship
  • 1983, Graduated cum laude
  • 1985–1988, National Dean's List
  • 1986–1988, Plough Scholarship
  • 1987–1988, R.H. Youngblood Scholarship
  • 1988, Member of the Rho Chi Pharmaceutical Honor Society, Beta Nu Chapter
  • 1988, Member of the Golden Key National Honor Society
  • 1988, Bristol Award, Bristol Laboratories
  • 1988, Graduated Magna cum laude with High Honors
  • 1990–1994, University Graduate Scholarship
  • 1996, Post-doctoral Research Forum, 1st Place (43 participants); University of Cincinnati College of Medicine
  • 2001 Regional Ozone Coalition – Clean Air-a Thon Award

Research Grants and Contracts

  • R01 HL75562-06A1 Prows, PI (05/01/09 – 04/30/13)    NHLBI - $295,265
    Genetic Analysis of Hyperoxia-Induced Acute Lung Injury
    The goal of this research is to generate reciprocal congenic lines of mice for the 5 Shali QTLs; determine the best QTL combination in multi-congenic lines; generate reciprocal congenic substrains for Shali1; narrow Shali1 interval and identify candidate and positional candidate genes involved in survival time to hyperoxic acute lung injury using in vivo, in vitro and in silico strategies.
    Role: PI

Publications, Most Recent

  • Wesselkamper, S.C., McDowell, S.A., Medvedovic, M., Dalton, T.P., Deshmukh, H.S., Sartor, M.A., Case, L.M., Henning, L.N., Borchers, M.T., Tomlinson, C.R., Prows, D.R., and Leikauf, G.D.  The role of metallothionein in the pathogenesis of acute lung injury.  Am. J. Respir. Cell Mol. Biol. 34: 73–82, 2006.
  • Prows, D.R., Hafertepen, A.P., Gibbons, Jr., W.J., Winterberg, A.V., and Nick, T.G. A mouse model of hyperoxic acute lung injury survival.Physiol. Genomics 30: 262–270, 2007
  • Prows, D.R., Hafertepen, A.P., Winterberg, A.V., Gibbons, Jr., W.J., Liu, C-Y., and Nick, T.G. Genetic analysis of hyperoxic acute lung injury survival in reciprocal intercross mice.  Physiol. Genomics 30: 271–281, 2007.
  • Prows, D.R., Hafertepen, A.P., Winterberg, A.V., Gibbons, Jr., W.J., Wesselkamper, S.C., Singer, J.B., Hill, A.E., Nadeau, J.H., & Leikauf, G.D. Reciprocal congenic lines of mice capture the Aliq1 effect on acute lung injury survival time.  Am. J. Respir. Cell Mol. Biol. 38: 68–77, 2008.
  • Glasser, S.W., Senft, A.P., Whitsett, J.A., Maxfield, M.D., Ross, G.F., Richardson, T.R., Prows, D.R., Xu, Y., and Korfhagen, T.R. Macrophage dysfunction and susceptibility to pulmonary Pseudomonas aeruginosa infection in surfactant protein C-deficient mice.  J. Immunol. 181: 621–628, 2008.
  • Glasser, S.W., Witt, T.L., Korfhagen, T.R., Folger, D., Maxfield, M.D., Senft, A.P., Baatz, J.E., Prows, D.R., and Whitsett, J.A. Pulmonary surfactant protein C deficiency enhances susceptibility to Respiratory Syncytial Virus infection.  Am. J. Physiol. Lung Cell. Mol. Physiol. 297: L64–72, 2009.
  • Prows, D.R., Winterberg, A.V., Gibbons, Jr., W.J., Liu, C-Y., and Nick, T.G. Reciprocal backcross mice confirm the major loci for hyperoxic acute lung injury survival time.  Physiol. Genomics 38: 158–168, 2009.
  • Bein, K., Wesselkamper, S.C., Liu, X-D., Dietsch, M., Majumber, N., Concel, V.J., Medvedovic, M., Sartor, M., Henning, L.N., Venditto, C., Borchers, M.T., Barchowsky, A., Weaver, T.E., Tichelaar, J.W., Prows, D.R., Korfhagen, T.R., Hardie, W.D., Bachurski, C.J., and Leikauf, G.D. Surfactant associated protein B is critical to survival in acute lung injury in mice.  J. Respir. Cell Mol. Biol. 41: 226–236, 2009.
  • Stark, J.M., Barmada, M., Winterberg, A.V., Mujumber, N., Gibbons, Jr., W.J., Horner, Stark, M.A., M.L., Sartor, M., Medvedovic, M., Kolls, J., Bein, K., Heinzmann, A., Leikauf, G.D., and Prows, D.R. Genomewide association analysis of severe respiratory syncytial virus infection.  J. Virol. (resubmitted 7/2009).
  • Yang, R., Wang, X., Wu, Z., Prows, D.R., and Lin, M.  Bayesian model selection for characterizing genomic imprinting effects and patterns.  Bioinformatics (submitted, 9/2009).

Professional Organization Memberships

Abstracts

  • Prows, D.R., Horner, M.L., Hafertepen, A.P., Gibbons, W.J., Monfils, M. and Folger, D.L. Chromosomal linkage identified for hyperoxia-induced acute lung injury survival in mice.  Proc. Am. Thorac. Soc. 2: A147; 2005.
    • Poster presentation, American Thoracic Society International Conference, San Diego, CA; 2005.
  • Hardie, W.D., Leikauf, G.D., Case, L.M., Wesselkamper, S.C., Prows, D.R., and Korfhagen, T.R. TGF-alpha signaling in respiratory epithelial cells protects during acute lung injury.  Proc. Am. Thorac. Soc. 2: A837; 2005.
  • Prows, D.R., Hafertepen, A.P., Gibbons, Jr., W.P. and Winterberg, A.V. Chromosome substitution strain supports Aliq2 on Chr 13 as susceptibility QTL for ozone-induced acute lung injury survival.  Proc. Am. Thorac. Soc. 3: A571; 2006.
    • Poster discussion/presentation, American Thoracic Society International Conference, San Diego, CA; 2006.
  • Glasser, S.W., Maxfield, M.D., Davis, K.R., Hardie, W.D., Prows, D.R., and Korfhagen, T.R. Transgenic expression of TGF-alpha promotes inflammation in SP-C deficient mice.  Proc. Am. Thorac. Soc. 3: A228; 2006.
  • Prows, D.R., Hafertepen, A.P., Gibbons, Jr., W.J., Winterberg, A.V. and Hogan, A.G. Genetic analysis of hyperoxia-induced acute lung injury survival in mice.
    • Poster presentation, 5th Annual Complex Trait Consortium, Chapel Hill, NC; 2006.
  • Prows, D.R., Hafertepen, A.P., Winterberg, A.V., Gibbons, Jr., W.J. and Nick, T.G. Genetic analysis of hyperoxia-induced acute lung injury survival.  Am. J. Respir. Crit. Care Med. 175: A951; 2007.
    • Poster presentation, American Thoracic Society International Conference, San Francisco, CA; 2007.
  • Leikauf, G.D., Winterberg, A.V., Hafertepen, A.P., Gibbons, W.J. Jr., Wesselkamper, S.C., Mason, J., Dietsch, M., Wang, D., You, M., and Prows D.R. Genetic complexity of survival during acute lung injury in mice.  Am. J. Respir. Crit. Care Med. 175: A949; 2007.
  • Stark, J.M., Winterberg, A.V., Gibbons, Jr., W.J., Leikauf, G.D., and Prows, D.R. Genetic determinants of respiratory syncytial virus (RSV) susceptibility in inbred mice.  Am. J. Respir. Crit. Care Med. 175: A760; 2007.
  • Prows, D.R., Winterberg, A.V., Gibbons, Jr, W.J., Liu, C. and Nick, T.G. Genetic analysis of hyperoxic acute lung injury survival in mice. Keystone Symposium: Complex Traits: Biologic and Therapeutic Insights; Santa Fe, NM; 2008.
  • Prows, D.R., Winterberg, A.V., Thompson, A.L., and Gibbons, Jr., W.J. A panel of overlapping chromosome 13 congenic strains captured the Aliq2 effect and narrowed the QTL interval for acute lung injury survival time.  Am. J. Respir. Crit. Care Med. 177: A752; 2008.
    • Poster presentation, American Thoracic Society International Conference, Toronto, Canada; 2008.
  • Glasser, S.W., Witt, T.L., Folger, D.L., Maxfield, M.D., Senft, A.P., Prows, D.R., Baatz, J.E., and Korfhagen, T.R. RSV induced pulmonary inflammation is increased in SP-C deficient mice.  Am. J. Respir. Crit. Care Med. 177: A585; 2008.
  • Stark, J.M., Leikauf, G.D., and Prows, D.R. Candidate genes for respiratory syncytial virus susceptibility in mice. 108th General Meeting of the American Society for Microbiology, Boston, MA; 2008.
  • Stark, J.M., Leikauf, G.D., and Prows, D.R.  Role of Cftr in RSV susceptibility: an inbred mouse model. 22nd Annual North American Cystic Fibrosis Conference, Orlando, FL; 2008.

Books

  • Leikauf, G.D., Prows, D.R., Shertzer, H.G., Carrigan, P.E., Zhao, Q., Borchers, M.T., Ormerod, E., Simpson, L.G., Weaver, T.E., Clark, J.C., Lee, N.A., Whitsett, J.A., Lee, J.J., and Driscoll, K.E.  Asthma and acute lung injury: transgenic models and genetic determinants. In: Relationships between Respiratory Disease and Exposure to Air Pollution. Dungworth, D.L., Brain, J.D., Driscoll, K.E., Grafström, R.C., and Harris, C.C. (eds.) ILSI Press, Washington, D.C., pp. 45–58, 1998.
  • Leikauf, G.D., Borchers, M.T., Hardie, W.D., Korfhagen, T.R., Wesselkamper, S.C., McDowell, S.A., and Prows, D.R.  Susceptibility to air pollution: genetic determinants and transgenic models.In: Relationships between Acute and Chronic Effects of Air Pollution. Bates, D.V., Brain, J.D., Driscoll, K.E., Dungworth, D.L., Grafström, R.C., Harris, C.C., Heyder, J., Koren, H.S., Mauderly, J.L., Pauluhn, J., Samet, J.M., and Utell, M.J. (eds.) ILSI Press, Washington, D.C., pp. 97–111, 2000.
  • Leikauf, G.D. and Prows, D.R.  Inorganic compounds of carbon, nitrogen and oxygen. In: Patty’s Industrial Hygiene and Toxicology. 5th ed. Vol. 3. Bingham, E., Cohrssen, B. and Powell, C. (eds.) Wiley and Sons, New York, pp. 607–730, 2001.
  • Leikauf, G.D., McDowell, S.A., Simpson, L.G., Borchers, M.T., Hardie, W.D., Korfhagen, T.R., McGraw, D., Liggett, S., Aronow, B.J., Bachurski, C.J., and Prows, D.R.  Strategic transgenesis in pulmonary pathogenomics. In: Crucial Issues in Inhalation Research – Mechanistic, Clinical, and Epidemiologic.Heinrich, U. and Mohr, U. (eds.) Fraunhofer IRB Verlag, Stuttgart (pp. 39–55), 2002.
  • Leikauf, G.D., Wesselkamper, S.C., Bachurski, C., Medvedovic, M., Sartor, M.A., Tomlinson, C.R., McDowell, S.A., Case, L.M., Haffey, B.D., Henning, L.M., Horner, M.L., Aronow, B.J., Hardie, W.D., Korfhagen, T.R., and Prows, D.R.  Transcriptional Regulatory Networks in Acute Lung Injury.In: Effects of Air Contaminants on the Respiratory Tract – Interpretations from Molecules to Meta-Analysis. U. Heinrich (ed.), Fraunhofer IRB Verlag, Stuttgart, Germany, pp. 373–396, 2004.
  • Leikauf, G.D. and Prows, D.R.  Inorganic compounds of carbon, nitrogen and oxygen. In: Patty’s Industrial Hygiene and Toxicology. 6th ed. (in preparation).