Human Genetics

Xiaoyang Qi, PhD

Appointment

Research Assistant Professor, University of Cincinnati College of Medicine

Email

xiaoyang.qi@cchmc.org

Phone

513-636-5964

Fax

513-636-4373

Credentials

PhD: Biochemistry & Molecular Biology (1988-1991), Department of Biochemistry and Molecular Biology, Oklahoma State University, Stillwater, OK.

Research Fellow: (1992-1996) Division of Human Genetics Children's Hospital Medical Center, Cincinnati, OH.

Academic Appointment: Research Instructor (1996-present) Division of Human Genetics Children's Hospital Medical Center, Cincinnati, OH.

Awards and Honors

Co-Chair: Cancer Imaging: MRI, PET, and Molecular Imaging. The World Cancer Congress, Shanghai, China, 2008.
Changzhou First LingJunRenFu Award, China, 2007.
JiangSu Technology Innovation Award, China 2007.

Research

Biochemistry and molecular biology of Saposins: Structure studies by mean of the fluorescence spectroscopy, circular dichroism, NMR and site-directed mutagenesis method to gain insight into the structural requirements for saposins functions; Function studies by mean of the transgenic animal technology to elucidate saposins physiological multiple functional domain in vivo.

Research Grants and Contracts

NIH R43 (Co-PI: Qi) “SapC-DOPS nanovesicles for treating glioblastoma multiforme”
2008-2009.

NIH R43 (Co-PI: Qi) “A novel biotherapeutic treatment for pancreatic cancer” 2008-2009.

Bexion Pharmaceuticals Fund (PI: Qi) “Formulation study of SapC-DOPS nanovesicles” 2008-2009.

CincyTech fund (Co-PI: Qi) “Formulation study of SapC-DOPS nanovesicles” 2008-2009.

NIH R43 (Co-PI: Qi) “A novel anti-neoplastic agent for the treatment of primary and metastatic prostate cancer” 2007-2008.

MTTI Industrial Fund (PI: Qi) “Quantitation of CellVue™ dye uptake by pancreatic tumors” 2007-2008.

Lysosomal Storage Disease Research Consortium Fund (PI: Qi) “The physiological importance of saposin C’s fusogenicity” 2007-2008.

Publications, Most Recent

M.P. Nieh, J. Pencer, J. Katsaras, and X. Qi, Spontaneously formed bimodal phospholipid unilamellar ellipsoidal vesicles and their interactions with helical domains of saposinC. Langmuir (2006) 22, 11028-11033.

W. Yuan, X. Qi, P. Tsang, S-J. Kang, P.A. Illaniorov, G.S. Besra, J. Gumperz, and P. Cresswell, Saposin B is the dominant saposin that facilitates lipid binding to human CD1d molecules. Proc. Natl. Acad. Sci. USA. (2007) 104, 5551-5556.

S.A. Baker, X. Qi, and G. Lorigan, Investigating the interaction of saposin C with POPS and POPC phospholipids: a solid-state NMR spectroscopic study. Biophys. J. (2007) 93, 3480-3490.

M.P. Nieh, J. Katsaras, and X. Qi, Controlled release mechanisms of temperature-sensitive, low-polydispersity, spontaneously forming unilamellar vesicles. Biochim. Biohys. Acta (2008) 1778, 1467-1471.

A. Liu and X. Qi, Molecular dynamics simulation of saposin C-membrane binding. The Open Struct. Biol. J. (2008) 2, 21-30.

Presentations, Most Recent

SapC-DOPS Nanovesicle: Saposin C-DOPS nanovesicles: tumor-targeting and anticancer activity. National Health Research Institutes, Taiwan, October 2008

Novel SapC-lipid nanovesicles for targeted tumor-imaging. The World Cancer Congress, Shanghai, China, June 2008. Co-Chair: Cancer Imaging: MRI, PET and Molecular Imaging.

Phosphatidylserine targeted nanovesicles for tumor imaging. Cincinnati Children’s Hospital Research Foundation, Center for Imaging Research, Cincinnati, USA, February 2007.

SapC-DOPS: pancreatic cancer therapy. Nanjing University, Nanjing, China, June 2006.

Professional Organization Memberships

American Society for Biochemistry and Molecular Biology

The American Society of Human Genetics

Society for Neuroscience

Abstracts

Z. Chu, X. Qi, SapC-DOPS Nanovesicles: anticancer activity and molecular mechanism. The World Cancer Congress (June, 2008) Shanghai, China.

V. Kaimal, S.K. Holland, Z. Chu, D.D. Richardson, X. Qi, Imaging the Targeted Delivery of the Protein Saposin C to Tumors in Mice. Joint Molecular Imaging Conference (September 2007) Providence, Rhode Island, USA.

H. Sundstrom, M. Walch, S. Latinovic-Golic, X. Qi, C. Dumrese, P. Groscurth, and U. Ziegler, Membrane Interactions and Oligomerization of the Antimicrobial Protein Granulysin. Basel Computational Biology Conference, USGEB (Union Schweizerischer Gesellschaften fuer Experimentelle Biologie) (March, 2007) Messe Basel, Switzerland.

X. Qi, Z. Chu, Y. Mahller, D. Witte, A. Lowy, T. Cripe, Development of A Novel Anticancer Drug for Commercialization. Ohio Valley Afflilication for Life Science Conference (March 2007) Cincinnati, Ohio, USA.

V. Kaimal, S.K. Holland, Z. Chu, D.D. Richardson, X. Qi, MRI of targeted delivery of saposin C and USPIO to tumor cells in vivo using liposomes. International Society for Magnetic Resonance in Medicine (ISMRM) Molecular and Cellular Imaging Study Group Workshop (February, 2007) Texas, U.S.A.

V. Kaimal, S.K. Holland, V.J. Schmithorst, X. Qi, MR Detection of tumor cells labeled with USPIO using DOPS liposomes. International Society for Magnetic Resonance in Medicine (ISMRM) Fourteenth Scientific Meeting and Exhibition (May, 2006) Seattle, Washington, U.S.A. (ISMRM Educational Stipend Award).