Susanne Wells, PhD
Appointment
Assistant Professor of Pediatrics
Email
susanne.wells@cchmc.org
Phone
513-636-5986
Fax
513-636-3549
Bio
Dr. Wells graduated from the University of Konstanz, Germany, with a degree in Biology. She completed her PhD in Molecular Biology at the State University of Stony Brook, NY, and her postdoctoral fellowship at Harvard Medical School, MA. Dr. Wells moved to Cincinnati Children's Hospital Medical Center in 2002 to study the antagonistic relationship between cellular transformation and senescence in the context of human papillomaviruses.
Credentials
BS: Biology, University of Konstanz, Germany, 1992
PhD: Molecular Genetics, State University of Stony Brook, NY, 1997
Postdoctoral Fellowship: Molecular Virology, Harvard Medical School, Boston, MA
Awards and Honors
- 2004: American Cancer Society Board Member, Hamilton Branch
- 2004: American Cancer Society Study Section member, Ohio Division
- 2001: NRSA Postdoctoral Fellowship
- 2000: The Medical Foundation Postdoctoral Fellowship
- 1999: Taplin Research Postdoctoral Fellowship
Research
Visit the Wells Lab Site.
Papillomavirus biology, molecular mechanisms of cellular growth and senescence.
Research Grants and Contracts
1R01CA116316-01 (Wells) April 2006-March 2010 NIH
Role and regulation of the human DEK proto-oncogene
Translational Research Initiative Award(Wells) July 2006-June 2007
HPV infection and associated malignancies in Fanconi Anemia patients
1R01CA102357-01A1 (Wells) April 2004-March 2008 NIH
Papillomavirus proteins mediating cancer and senescence
Publications, Most Recent
Connect to Susanne Wells' publications on PubMed
Wise-Draper, T. M., and Wells, S. I. 2008. Papillomavirus E6 and E7 proteins and their cellular targets. In: Front. in Biosci., 13; 1003-1017.
Jones, E. E. and Wells, S. I. Cervical cancer and human papillomaviruses: inactivation of retinoblastoma and other tumor suppressor pathways. Curr Mol Med. 2006 Nov;6(7):795-808.
Wise-Draper TM, Allen HV, Thobe MN, Jones EE, Habash KB, Munger K, Wells SI. The human DEK proto-oncogene is a senescence inhibitor and an upregulated target of high-risk human papillomavirus E7.J Virol. 2005 Nov;79(22):14309-17.
Wise-Draper TM and Wells SI. (2005) Efficient Delivery of siRNA targeted against Human Papillomavirus Oncogenes.Biochemica (Roche Newsletter). 1; 14-16.
Williams, S.S., Aronow, B. J., and Wells, S. I. 2005. Gene program signatures for papillomavirus E2-mediated senescence in cervical cancer cells: Finding the points of no return. The Oncogenomics Handbook, Cancer Drug Discover and Development Series. R.A. Shimkets and W.J. LaRochelle (ed.), The Humana Press, Inc. Totowa, NJ, 69-88.
Wells SI, Aronow BJ, Wise TM, Williams SS, Couget JA, Howley PM. Transcriptome signature of irreversible senescence in human papillomavirus-positive cervical cancer cells.Proc Natl Acad Sci U S A. 2003 Jun 10;100(12):7093-8.
Presentations, Most Recent:
2007. Nineteenth Annual Fanconi Anemia Research Fund Scientific Symposium. Chicago, IL, USA. The high risk HPV E7 protein mediates coordinate regulation of Fanconi anemia genes through the Rb/E2F pathway. Elizabeth E. Jones, Kristen B. Habash, Trisha M. Wise-Draper, Michael Jansen, Patrick Kelly, David A. Williams, Erik S. Knudsen and Susanne I. Wells
2007. International ICGEB DNA Tumor Virus Meeting. Trieste, Italy. The human DEK proto-oncogene is involved in DNA damage response pathways. Trisha M. Wise-Draper, Paul R. Andreassen and Susanne I. Wells
2006. International DNA Tumor Virus Meeting, San Diego, CA, USA. Apoptosis inhibition by the human DEK oncoprotein involves p53. Trisha M. Wise-Draper, Hillary V. Allen, Elizabeth E. Jones, Kristen B. Habash, Hiroshi Matsuo, and Susanne I. Wells
2006. International DNA Tumor Virus Meeting, San Diego, CA, USA. Molecular cross-talk between HPV and Fanconi Anemia pathways. Elizabeth E. Jones, Kristen B. Habash, Paul R. Andreassen and Susanne I. Wells
Related Areas
This person works in these other areas at Cincinnati Children's Hospital Medical Center:
