Wells Laboratory Research Interests
HPV-associated tumors have been recognized and studied for decades, but surprisingly, specific cellular genes that predispose an infected individual to viral replication and tumorigenesis are largely unknown. Our long term interest is to identify new targets of the HPV E6/E7 oncogenes, and to characterize these as potential risk factors for HPV infection and transformation. We apply bioinformatics approaches, analyses of primary, transformed and 3D cell culture systems as well as mouse tumor models to translational endeavors. These are in close collaboration with physician researchers at Children¹s Hospital and at the University of Cincinnati.
Current Projects
