Immunobiology

Fred D. Finkelman, MD

Title

Professor

Email

ffinkelman@pol.net

Phone

513 636 6656

Fax

513 636 5355

Bio

Learn more about Dr. Finkelman at his University of Cincinnati Lab Page

Credentials

BA Biology, Queens College, Queens, NY 1967

MD Yale University, 1971

Residency Internal Medicine, Yale-New Haven Hospital, 1973

Position History

1973-75 Research Associate, Laboratory of Immunology, NIAID, NIH

1975-77 Fellow, Rheumatology Section, Dept of Internal Med, Univ. of Texas Health Science Center at Dallas

1977-80 Asst Professor, Dept of Medicine, Uniformed Services University of the Health Sciences, Bethesda, MD

1980-86 Assoc Professor, Dept of Medicine, Uniformed Services University of the Health Sciences, Bethesda, MD

1984-95 Director, Div of Rheumatology, Dept of Med, Uniformed Services Univ of the Hlth Sci, Bethesda, MD

1986-95 Professor, Dept of Medicine, Uniformed Services University of the Health Sciences, Bethesda, MD

1995-present McDonald Prof. of Med., and Director, Div. of Immunol., Univ. Cincinnati Col. Med., Cincinnati, OH

1995-present Director, Rheumatology Division, Cincinnati Veterans Administration Medical Center, Cincinnati, OH

2001-present Prof., Dept. Pediatrics, Div. Immunobiol., Children's Hospital Med. Res. Foundation, Cincinnati, OH

Awards and Honors

Phi Beta Kappa, Queens College, 1967
Alpha Omega Alpha, Yale University School of Medicine, 1970

Research

Cytokine control of immune-mediated disorders and host protection against parasites, cytokine regulation of allergic disorders, cytokine regulation of lymphopoiesis, regulation of cytokine responses and mechanisms of lymphocyte activation and tolerance

Research Grants and Contracts

Cytokine regulation of a mouse model of asthma (NIH/NIAID, 1RO1 AI45766-01), 9/99-8/05

Cellular targets of IL-4 and IL-13 in worm expulsion (NIH/NIAID, 1RO1 AI 052099-01A1), 4/03-3/08

Role of inflammatory cytokines in the allergic response (NIH/NIAID, 1RO1 AI55848), 8/03-1/08

Interleukin-13 in experimental asthma (NIH/NHLBI, 1 P01 HL076383-01, Marsha Wills-Karp, PI), 4/04-3/09
Specific Involvements: PI, Project 2, Unique effects of IL-13 in asthma: a mechanistic analysis; co-PI, Project 3, Role of eotaxins and CCR3 in IL-13-induced asthma; co-PI, Project 4, Role of IL-13 receptor alpha 2 in allergic inflammation;

Cytokine regulation of anaphylaxis (VA Merit Award), 4/02 - 3/07

Mouse models of Pneumocystis infection (NIH/ NHLBI, R01 HL64570, Co-PI), 4/00 - 3/05

Biology of IL-13 Receptor Alpha 2 (NIH/NIAID, R01 AI058157-01, Co-PI), 1/04-12/08

Regulation of gastrointestinal eosinophils (NIH/NIAID, 1 R01 AI45898-01, Co-PI), 1/04-12/08

Eosinophil, chemokine, and IL-13 cooperativity in asthma (NIH/NIAID, 1 R01 AI057803-01, Co-PI), 1/04-12/08

Pathophysiology of local and systemic food allergy in a mouse model (Food Allergy and Anaphylaxis Network), 02/05-01/07

Publications, Most Recent

Khodoun M, Strait R, Orekov T, Hogan S, Karasuyama H, Herbert DR, Lohl J, Finkelman FD. (2009) Peanuts can contribute to anaphylactic shock by activating complement. J Allergy Clin Immunol Epub ahead of print.
Brandt EB, Munitz A, Orekov T, Mingler MK, McBride M, Finkelman FD, Rothenberg ME. (2009) Tarketing IL-4/IL-13 signaling to alleviate oral allergen-induced diarrhea. J Allergy Clin Immunol 123:53-8.
Herbert DR, Orekov T, Perkins C, Finkelman FD. (2008) IL-10 and TGF-beta redundantly protect against severe liver injury and mortality during acute schistosomiasis. J Immunol 181:7214-20.
LeGos G, Ben-Sasson SZ, Seder R, Finkelman FD, Paul WE. (2008) Generation of interleukin 4 (IL-4)-producing cells in vivo and in vitro: IL-2 and IL-4 are required for in vitro generation of IL-4-producing cells. J Immunol 181:2943-51.
Yamada Y, Sanchez-Aguilera A, Brandt EB, McBride M, Al-Moamen NJ, Finkelman FD, Williams DA, Cancelas JA, Rothenberg ME. (2008) FIP1L1/PDGFRalpha synergizes with SCF to induce systemic mastocytosis in a murine model of chronic eosinophilic leukemia-hypereosinophilic syndrome. Blood 112:2500-7.
Wills-Karp, Finkelman, FD. (2008) Untangling the complex web of IL-4- and IL-13-mediated signaling pathways. Sci Signal. 1:pe55.
Munitz A, Brandt EB, Mingler M, Finkelman FD, Rothenberg ME. (2008) Distinct roles for IL-13 and IL-4 via IL-13 receptor alpha1 and the type II IL-4 receptor in asthma pathogenesis. Proc Natl Acad Sci U S A 105:7240-5.
Forbes EE, Groschwitz K, Abonia JP, Brandt EB, Cohen E, Blanchard C, Ahrens R, Seidu L, McKenzie A, Strait R, Finkelman FD, Foster PS, Matthaei KI, Rothenberg ME, Hogan SP. (2008) IL-9- and mast cell-mediated intestinal permeability predisposes to oral antigen hypersensitivity. J Exp Med 205:897-913.
Herbert DR, Orekov T, Perkins C, Rothenberg ME, Finkelman FD. (2008) IL-4R alpha expression by bone marrow-derived cells is necessary and sufficient for host protection against acute schistosomiasis. J Immunol 180:4948-55
Finkelman FD, Wills-Karp M. (2008) Usefulness and optimization of mouse models of allergic airway disease. J Allergy Clin Immunol 121:603-6.
Finkelman FD. (2008) Use of unrestrained, single chamber barometric plethysmography to elevate sensitivity to cholinergic stimulation in mouse models of allergic airway disease. J Allergy Clin Immunol 121:334-5.
Phelan JD, Orekov T, Finkelman FD. (2008) Cutting edge: Mechanism of enhancement of in vivo cytokine effects by anti-cytokine monoclonal antibodies. J Immunol 180:44-8.
Simons FE, Frew AJ, Ansotegui IJ, Bochner BS, Golden DB, Finkelman FD, Leung DY, Lotvall J, Marone G, Metcalfe DD, Muller U, Rosenwasser LJ, Sampson HA, Schwartz LB, van Hage M, Walls AF. (2008) Practical allergy (PRACTALL) report: risk assessment in anaphylaxix. Allergy 63:35-7.
Khodoun M, Lewis CC, Yang JQ, Orekov T, Potter C, Wyinn T, Mentink-Kane M, Hershey GK, Wills-Karp M, Finkelman FD. (2007) Differences in expression, affinity, and function of soluble (s)IL-4Ralpha and sIL-13Ralpha2 suggest opposite effects on allergic responses. J Immunol 179:6429-38.
Finkelman FD. (2007) Anaphylaxis: lessons from mouse models. J Allergy Clin Immunol 120:506-15.
Finkelman FD, Vercelli D. (2007) Advances in asthma, allergy mechanisms, and genetics in 2006. J Allergy Clin Immunol 120:544-50.
Wojciechowski S, Tripathi P, Bourdeau T, Acero L, Grimes HL, Katz JD, Finkelman FD, Hildeman DA. (2007) Bim/Bcl-2 balance is critical for maintaining naive and memory T cell homeostasis. J Exp Med 204:665-75.
Munitz A, Bachelet I, Finkelman FD, Rothenberg ME, Levi-Schaffer F. (2007) CD48 is critically involved in allergic eosinophilic airway inflammation. Am J Respir Crit Care Med. 175:911-8.
Horsnell WG, Cutler AJ, Hoving JC, Mearns H, Myburgh E, Arendse B, Finkelman FD, Owens GK, Erle D, Brombacher F. (2007) Delayed goblet cell hyperplasia, acetylcholine receptor expression, and worm expulsion in SMC-specific IL-4Ralpha-deficient mice. PLoS Pathog 3(1):e1
Rothenberg ME, Doepker MP, Lewkowich IP, Chiaramonte MG, Stringer KF, Finkelman FD, MacLeod CL, Ellies LG, Zimmermann N. (2006) Cationic amino acid transporter 2 regulates inflammatory homeostasis in the lung. Proc Natl Acad Sci U S A 103:14895-900
Perkins C, Wills-Karp M, Finkelman FD. (2006) IL-4 induces IL-13-independent allergic airway inflammation. J Allergy Clin Immunol 118:410-9.
Zhao A, Urban JF Jr, Morimoto M, Elfrey JE, Madden KB, Finkelman FD, Shea-Donohue T. (2006)
Contribution of 5-HT2A receptor in nematode infection-induced murine intestinal smooth muscle hypercontractility. Gastroenterology. 131:568-78.
Akei HS, Brandt EB, Mishra A, Strait RT, Finkelman FD, Warrier MR, Hershey GK, Blanchard C, Rothenberg ME. (2006) Epicutaneous aeroallergen exposure induces systemic TH2 immunity that predisposes to allergic nasal responses. J Allergy Clin Immunol. 118(1):62-9.
Munitz A, Bachelet I, Eliashar R, Khodoun M, Finkelman FD, Rothenberg ME, Levi-Schaffer F. (2006) CD48 is an allergen and IL-3-induced activation molecule on eosinophils. J Immunol. 177(1):77-83.
Seo SJ, Fields ML, Buckler JL, Reed AJ, Mandik-Nayak L, Nish SA, Noelle RJ, Turka LA, Finkelman FD, Caton AJ, Erikson J. (2002) The impact of T helper and T regulatory cells on the regulation of anti-double-stranded DNA B cells.Immunity 16:535-46.
Seo SJ, Fields ML, Buckler JL, Reed AJ, Mandik-Nayak L, Nish SA, Noelle RJ, Turka LA, Finkelman FD, Caton AJ, Erikson J. (2002) 16:535-46.
Strait RT, Morris SC, Yang M, Qu XW, Finkelman FD. (2002) Pathways of anaphylaxis in the mouse.J Allergy Clin Immunol 109:658-68.
Xu H, Wipasa J, Yan H, Zeng M, Makobongo MO, Finkelman FD, Kelso A, Good MF. (2002) The mechanism and significance of deletion of parasite-specific CD4(+) T cells in malaria infection.J Exp Med 195:881-92.
Morris SC, Dragula NL, Finkelman FD. (2002) IL-4 promotes Stat6-dependent survival of autoreactive B cells in vivo without inducing autoantibody production.J Immunol 169:1696-704.
Woo AL, Gildea LA, Tack LM, Miller ML, Spicer Z, Millhorn DE, Finkelman FD, Hassett DJ, Shull GE. (2002) In vivo evidence for interferon-gamma-mediated homeostatic mechanisms in small intestine of the NHE3 Na+/H+ exchanger knockout model of congenital diarrhea.J Biol Chem 277:49036-46.
Singh RR, Ebling FM, Albuquerque DA, Saxena V, Kumar V, Giannini EH, Marion TN, Finkelman FD, Hahn BH. (2002) Induction of autoantibody production is limited in nonautoimmune mice.J Immunol 169:587-94.
Liu E, Moriyama H, Abiru N, Miao D, Yu L, Taylor RM, Finkelman FD, Eisenbarth GS. (2002) Anti-peptide autoantibodies and fatal anaphylaxis in NOD mice in response to insulin self-peptides B:9-23 and B:13-23.J Clin Invest 110:1021-7.
Madden KB, Whitman L, Sullivan C, Gause WC, Urban JF, Jr., Katona IM, Finkelman FD, Shea-Donohue T. (2002) Role of STAT6 and mast cells in IL-4- and IL-13-induced alterations in murine intestinal epithelial cell function.J Immunol 169:4417-22.
Strait RT, Morris SC, Smiley K, Urban JF, Jr., Finkelman FD. (2003) IL-4 exacerbates anaphylaxis.J Immunol 170:3835-42.
Brandt EB, Strait RT, Hershko D, Wang Q, Muntel EE, Scribner TA, Zimmermann N, Finkelman FD, Rothenberg ME. (2003) Mast cells are required for experimental oral allergen-induced diarrhea.J Clin Invest 112:1666-77.
Gildea LA, Gibbons R, Finkelman FD, Deepe GS, Jr. (2003) Overexpression of interleukin-4 in lungs of mice impairs elimination of Histoplasma capsulatum.Infect Immun 71:3787-93.
Zhao A, McDermott J, Urban JF, Jr., Gause W, Madden KB, Yeung KA, Morris SC, Finkelman FD, Shea-Donohue T. (2003) Dependence of IL-4, IL-13, and nematode-induced alterations in murine small intestinal smooth muscle contractility on Stat6 and enteric nerves.J Immunol 171:948-54.
Singh RR, Saxena V, Zang S, Li L, Finkelman FD, Witte DP, Jacob CO. (2003) Differential contribution of IL-4 and STAT6 vs STAT4 to the development of lupus nephritis.J Immunol 170:4818-25.
Nikolaidis NM, Zimmermann N, King NE, Mishra A, Pope SM, Finkelman FD, Rothenberg ME. (2003) Trefoil factor-2 is an allergen-induced gene regulated by Th2 cytokines and STAT6 in the lung.Am J Respir Cell Mol Biol 29:458-64.
Strait R, Morrist SC, Finkelman FD. (2004) Cytokine enhancement of anaphylaxis.Novartis Found Symp 257:80-91; discussion 91-100, 276-85.
Min B, Prout M, Hu-Li J, Zhu J, Jankovic D, Morgan ES, Urban JF, Jr., Dvorak AM, Finkelman FD, LeGros G, Paul WE. (2004) Basophils produce IL-4 and accumulate in tissues after infection with a Th2-inducing parasite.J Exp Med 200:507-17.
Sussman JJ, Parihar R, Winstead K, Finkelman FD. (2004) Prolonged culture of vaccine-primed lymphocytes results in decreased antitumor killing and change in cytokine secretion.Cancer Res 64:9124-30.
Fulkerson PC, Zimmermann N, Hassman LM, Finkelman FD, Rothenberg ME. (2004) Pulmonary chemokine expression is coordinately regulated by STAT1, STAT6, and IFN-gamma.J Immunol 173:7565-74.
Wan H, Kaestner KH, Ang SL, Ikegami M, Finkelman FD, Stahlman MT, Fulkerson PC, Rothenberg ME, Whitsett JA. (2004) Foxa2 regulates alveolarization and goblet cell hyperplasia.Development 131:953-64.
Liu Q, Arseculeratne C, Liu Z, Whitmire J, Grusby MJ, Finkelman FD, Darling TN, Cheever AW, Swearengen J, Urban JF, Gause WC. (2004) Simultaneous deficiency in CD28 and STAT6 results in chronic ectoparasite-induced inflammatory skin disease.Infect Immun 72:3706-15.
Puliaev R, Nguyen P, Finkelman FD, Via CS. (2004) Differential requirement for IFN-gamma in CTL maturation in acute murine graft-versus-host disease.J Immunol 173:910-9.
Han S, Zhang X, Xu R, Finkelman FD, Brombacher F, Zheng B. (2004) IgD+IgM- B cells mount immune responses that exhibit altered antibody repertoire.Eur J Immunol 34:661-8.
Kelly-Welch AE, Wang HY, Wang LM, Pierce JH, Jay G, Finkelman F, Keegan AD. (2004) Transgenic expression of insulin receptor substrate 2 in murine B cells alters the cell density-dependence of IgE production in vitro and enhances IgE production in vivo.J Immunol 172:2803-10.
Finkelman FD, Yang M, Orekhova T, Clyne E, Bernstein J, Whitekus M, Diaz-Sanchez D, Morris SC. (2004) Diesel exhaust particles suppress in vivo IFN-gamma production by inhibiting cytokine effects on NK and NKT cells.J Immunol 172:3808-13.
Madden KB, Yeung KA, Zhao A, Gause WC, Finkelman FD, Katona IM, Urban JF, Jr., Shea-Donohue T. (2004) Enteric nematodes induce stereotypic STAT6-dependent alterations in intestinal epithelial cell function.J Immunol 172:5616-21.
Finkelman FD, Shea-Donohue T, Morris SC, Gildea L, Strait R, Madden KB, Schopf L, Urban JF, Jr. (2004) Interleukin-4- and interleukin-13-mediated host protection against intestinal nematode parasites.Immunol Rev 201:139-55.
Zucker S, Crabbe JC, Cooper Gt, Finkelman F, Largman C, McCarley RW, Rice L, Rubin J, Richardson B, Seil F, Snider GL, Vandenbark AA. (2004) Veterans Administration support for medical research: opinions of the endangered species of physician-scientists.Faseb J 18:1481-6.
Khodoun MV, Orekhova T, Potter C, Morris S, Finkelman FD. (2004) Basophils initiate IL-4 production during a memory T-dependent response.J Exp Med 200:857-70.
Liu E, Moriyama H, Abiru N, Paronen J, Devendra D, Finkelman FD, Eisenbarth GS. (2004) Preventing peptide-induced anaphylaxis: addition of C-terminal amino acids to produce a neutral isoelectric point.J Allergy Clin Immunol 114:607-13.
Smith A, Madden KB, Yeung KJ, Zhao A, Elfrey J, Finkelman F, Levander O, Shea-Donohue T, Urban JF, Jr. (2005) Deficiencies in selenium and/or vitamin E lower the resistance of mice to Heligmosomoides polygyrus infections.J Nutr 135:830-6.
Finkelman FD, Yang M, Perkins C, Schleifer K, Sproles A, Santeliz J, Bernstein JA, Rothenberg ME, Morris SC, Wills-Karp M. (2005) Suppressive effect of IL-4 on IL-13-induced genes in mouse lung.J Immunol 174:4630-8.
Zhao A, Morimoto M, Dawson H, Elfrey JE, Madden KB, Gause WC, Min B, Finkelman FD, Urban JF, Jr., Shea-Donohue T. (2005) Immune regulation of protease-activated receptor-1 expression in murine small intestine during Nippostrongylus brasiliensis infection.J Immunol 175:2563-9.
Peng JK, Lin JS, Kung JT, Finkelman FD, Wu-Hsieh BA. (2005) The combined effect of IL-4 and IL-10 suppresses the generation of, but does not change the polarity of, type-1 T cells in Histoplasma infection.Int Immunol 17:193-205.
Liu Z, Liu Q, Hamed H, Anthony RM, Foster A, Finkelman FD, Urban JF, Jr., Gause WC. (2005) IL-2 and autocrine IL-4 drive the in vivo development of antigen-specific Th2 T cells elicited by nematode parasites.J Immunol 174:2242-9.
Finkelman FD, Rothenberg ME, Brandt EB, Morris SC, Strait RT. (2005) Molecular mechanisms of anaphylaxis: lessons from studies with murine models.J Allergy Clin Immunol 115:449-57; quiz 458.
Zimmermann N, Doepker MP, Witte DP, Stringer KF, Fulkerson PC, Pope SM, Brandt EB, Mishra A, King NE, Nikolaidis NM, Wills-Karp M, Finkelman FD, Rothenberg ME. (2005) Expression and regulation of small proline-rich protein 2 in allergic inflammation.Am J Respir Cell Mol Biol 32:428-35.
West EE, Lavoie TL, Orens JB, Chen ES, Ye SQ, Finkelman FD, Garcia JG, McDyer JF. (2006) Pluripotent allospecific CD8+ effector T cells traffic to lung in murine obliterative airway disease.Am J Respir Cell Mol Biol 34:108-18.
Morimoto M, Morimoto M, Zhao A, Madden KB, Dawson H, Finkelman FD, Mentink-Kane M, Urban JF, Jr., Wynn TA, Shea-Donohue T. (2006) Functional importance of regional differences in localized gene expression of receptors for IL-13 in murine gut.J Immunol 176:491-5.
Strait RT, Morris SC, Finkelman FD. (2006) IgG-blocking antibodies inhibit IgE-mediated anaphylaxis in vivo through both antigen interception and Fc gamma RIIb cross-linking.J Clin Invest 116:833-41.
Morris SC, Orekhova T, Meadows MJ, Heidorn SM, Yang J, Finkelman FD. (2006) IL-4 induces in vivo production of IFN-gamma by NK and NKT cells.J Immunol 176:5299-305.

Professional Organization Memberships

American Society of Clinical Investigation
American Association of Immunologists
American College of Rheumatology
American Association of Physicians
American Association for Allergy, Asthma, and Immunology
Fellow, American Association for the Advancement of Science
Member, American Association of Immunologists Program Committee, 1994-1996
Member, American Association of Immunologists Nominations Committee, 2000-2001.
Member, American Association of Immunologists Public Affairs Committee, 2000-2002.
Member, NIAID Public Affairs Committee, 2001-2004
Member, NIH Transgenic Mouse Committee, 2001-
Member, Supervisory Committee for Immune Tolerance Network (in charge of Cytokine-related therapies for Allergy/Asthma subcommittee)
Member, Veterans Authority MRAG, 2002-
Member, Board of Directors, FASEB, 2004-
Chair, Veteran's Administration Research Funding Committee, 2004
Member, Finance Committee, 2004-
Member, Editorial Board and Associate Editor, Journal of Allergy and Clinical Immunology, 2005-

Teaching

Leader, Rheumatology/Immunology Journal Club (biweekly)
Leader, Immunology Research in Progress Conference (biweekly)
Co-organizer, Internal Medicine/Pediatrics Immunology Research Conference (biweekly)
Lecturer, Introductory Immunology Graduate Student course (5 lectures)
Co-director, Immunoparasitology Segment, Woods Hole Parasitology Summer Course, 1991-1994; Introductory lecture, 1999.
Attending, Arthritis Clinic (weekly), University of Cincinnati
Attending, Internal Medicine inpatient service, University of Cincinnati (1 month/year)