Immunobiology

Monica G. Chiaramonte, PhD

Title

Assistant Professor

Appointment

Research Assistant Professor of Pediatrics

Email

monica.chiaramonte@chmcc.org

Phone

513-636-0254

Fax

513-636-5355

Credentials

Biochemist. Faculty of Pharmacy and Biochemistry, University of Buenos Aires, Argentina. 1988.

PhD Area: Immunology. University of Buenos Aires, Argentina. 1993.

Visiting Fellow. Immunobiology Section, Laboratory of Parasitic Diseases, National Institutes of Allergy and Infectious Diseases, National Institutes of Health

Awards and Honors

"Fellows Award for Research Excellence 1998" Granted by National Institutes of Health, 1998.

First Place Award, "Best Paper 2002-2003". Awarded by Cytokine Interest Group, National Institutes of Allergy and Infectious Diseases, National Institutes of Health. March 2004.

Publications, Most Recent

Grunvald E; Chiaramonte M; Hieny S; Wysocka M; Trinchieri G; Vogel SN; Gazzinelli RT; Sher A. Biochemical characterization and protein kinase C dependency of monokine inducing activities in Toxoplasma gondii.Infection and Immunity. 64 (6): 2010-2018, 1996.

Kaplan D; Baldi C; Chiaramonte MG; Fernandez MM; Malchiodi EL; Levin M; Baldi A. Development of a recombinant monoclonal antibody fragment Fab against cruzipain, the major cysteine proteinase of Trypanosoma cruzi.Biochem Biophys Res Commun 253(1): 53-8, 1998.

Chiaramonte MG; Frank F; Furer GM; Taranto NJ; Margni RA; Malchiodi EL. Polymerase chain reaction reveals T. cruzi infection suspected by serology in cutaneous and mucocutaneous leishmaniasis patients.Acta Tropica. 72(3):295-308, 1999.

Chiaramonte MG; Schopf LR; Neben T; Cheever W; Donaldson DD; Wynn TA. IL-13 is a key regulatory cytokine for T helper 2 cell-mediated pulmonary granuloma formation and IgE responses induced by Schistosoma mansoni eggs.Journal of Immunology. 162(2):920-30, 1999.

Chiaramonte MG; Donaldson DD; Cheever AW; Wynn TA. An IL-13 inhibitor blocks the development of hepatic fibrosis during a T-helper type 2-dominated inflammatory response.Journal of Clinical Investigation. 104(6):777-85, 1999.

Chiaramonte MG; M Hesse,; AW Cheever; TA Wynn. CpG oligonucleotides can prophylactically immunize against Th2-mediated schistosome egg-induced pathology by an IL-12-independent mechanism.Journal of Immunology. 164(2):973-85, 2000.

Chiaramonte MG; Cheever AW; Malley JD; Donaldson DD; Wynn TA. Studies of murine schistosomiasis reveal interleukin-13 blockade as a treatment for established and progressive liver fibrosis.Hepat. 1:34(2):273-282, 2001.

Hoffmann KF; McCarty TC; Segal DH; Chiaramonte M; Hess M; Davis EM; Cheever AW; Meltzer PS; Morse HC; Wynn TA. Disease fingerprinting with cDNA microarrays reveals distinct gene expression profiles in lethal type-1 and type-2 cytokine-mediated inflammatory reactions.The FASEB Journal. Sept. 17, 2001.

Vaillant, B., M. G. Chiaramonte, A. W. Cheever, P. D. Soloway and T. A. Wynn. Regulation of hepatic fibrosis and extracellular matrix genes by the Th response: New insights into the role of tissue inhibitors of matrix metalloproteinases. J. Immunol. 167:7017-7026, 2001.

Chiaramonte MG, Mentink-Kane M, Jacobson BA, Cheever AW, Whitters MJ, Goad MEP, Wong A, Collins M, Donaldson DD, Grusby MJ, Wynn TA. Regulation and Function of the Interleukin-13 Receptor Alpha 2 during a Th2-dominant Immune Response. J. Exp. Med. 197:1-16, 2003.

Wills-Karp, M. and M. Chiaramonte. Interleukin-13 in asthma. Curr Opin Pulm Med, 9:21-27, 2003.

Wynn T. A., M. Hesse, N. G. Sandler, M. Kaviratne, K. F. Hoffmann, M. G. Chiaramonte, R. Reiman, A.W. Cheever, J. P. Sypek and M. M. Mentink-Kane. P-selectin suppresses hepatic inflammation and fibrosis in mice by regulating interferon gamma and the IL-13 decoy receptor.Hepatology. 39:676-687, 2004.

Addis-Lieser, E., J. Koehl and M. G. Chiaramonte. Opposing regulatory roles of complement factor 5 in the development of bleomycin-induced pulmonary fibrosis. J. of Immunol. 175:1894-1902, 2005.

Textbook chapter

"Electroforesis en geles de poliacrilamida. Isoelectroenfocado. Inmunotransferencia". ("Polyacrilamide electrophoresis. Isoelectrofocusing. Immunoblotting"). Margni RA, E. L. Malchiodi and M. G. Chiaramonte. In: Inmunología e Inmunoquímica (Immunology and Immunochemistry), 5th edition. Editorial Panamericana. 1997.

Professional Organization Memberships

2000-present
American Association of Immunologists

2000-present
Federation of American Societies of Experimental Biology (FASEB)

Teaching

Classroom Instruction

1985-1987 Teaching assistant. Course: Human Histology. (Faculty of Pharmacy and Biochemistry, University of Buenos Aires, Argentina

1987-1996 Teaching assistant. Courses: Immunology; Parasite Biology and Immunoparasitology. (Faculty of Pharmacy and Biochemistry, University of Buenos Aires, Argentina).

1989 Teaching assistant. "International Course of Advanced Immunochemistry". Post-graduate course. Sponsored by WHO, PAHO, University of Buenos Aires, and National Research Council of Argentina (CONICET).

2004 - Present Course: Foundations in Immunology II. Immunobiology Graduate Program. School of Medicine, University of Cincinnati.

Special Interests

immunological basis of pulmonary and hepatic fibrosis

Funded Training Programs

1985-1987: Teaching assistant. Course: Human Histology. (Faculty of Pharmacy and Biochemistry, University of Buenos Aires, Argentina).

1987-1996: Teaching assistant. Courses: Immunology; Parasite Biology and Immunoparasitology. (Faculty of Pharmacy and Biochemistry, University of Buenos Aires, Argentina).

1989: Teaching assistant. "International Course of Advanced Immunochemistry". Post-graduate course. Sponsored by WHO, PAHO, University of Buenos Aires, and National Research Council of Argentina (CONICET).