Xi Jason Jiang, PhD
Appointment
Professor
Email
jason.jiang@cchmc.org
Phone
513-636-0119
Fax
513-636-7655
Credentials
BS: Public Health, Shanghai Medical University, 1978
PhD: Virology and Epidemiology, Baylor College of Medicine, Houston, Texas, 1988
Post-doctoral fellow: Molecular Virology, Baylor College of Medicine, Houston, Texas, 1993
Position History
Sept. 2004-present Professor, Cincinnati Children's Hospital Medical Center
Sept.2001-Aug. 2004 Associate Professor, Cincinnati Children's Hospital Medical Center
July 1998-Aug. 2001 Associate Professor, Eastern Virginia Medical School
May 1993-June 1998 Assistant Professor, Eastern Virginia Medical School
July 1988-April 1993 Research Associate, Baylor College of Medicine, Molecular Virology
Oct. 1978-Feb. 1983 Instructor, Microbiology, Shanghai Medical University, Public Health
Awards and Honors
Second prize, Shanghai Medical Society, "Cholera Etiology Study in Coastal Area of China," 1983
The 35th Interscience Conference on Antimicrobial Agents and Chemotherapy (ICAAC) Young Investigator Award, 1995
Research Grants and Contracts
NIH R01 AI37093, Characterization of Human Calicivirus, 4/02-3/07, PI.
NIH P01 HD 13021, Viral Gastroenteritis Project, 04/03-03/09, PI.
NIH P01 HD 13021, Molecular Biology Core, 04/03-03/09, PI.
USAMRMC/DoD PR033018, Development of strategies to treat and prevent norovirus infections, 2/04-1/09, PI
NIH R01 AI 055649, Norwalk-like viruses and their receptors, 8/05-02/10, PI
Presentations
Norovirus / host interaction: implication in disease control and prevention. Korea Society for Microbiology and Biotechnology, International Symposium and Annual Meeting, Seoul, Korea, June 2007.
Update of norovirus research. Sakai City Health Department, Osaka, Japan, June 2007.
Norovirus / host interaction: implication in disease control and prevention. National Institute of Infectious Diseases, Tokyo, Japan, June 2007.
Norovirus / host interaction: implication in disease control and prevention. Division of Infectious Diseases, The University of Cincinnati, Cincinnati, Ohio, January 15, 2008.
Publications, Most Recent
Tan, M., J. Meller, and X. Jiang. C-terminal arginine cluster is essential for receptor binding of norovirus capsid protein. J Virol, 2006; 80:7322-31.
Feng, X. and X. Jiang. Library screen for inhibitors targeting norovirus binding to histo-blood group antigen receptors. Antimicrob Agents Chemother, 2007; 51(1): 324-31.
Xia, M., T. Farkas, Xi Jiang. Norovirus capsid protein expressed in yeast forms virus-like particles and stimulates systemic and mucosal immunity in mice following an oral administration of raw yeast extracts. J Med Virol, 2007; 79(1): 74-83.
Sheng Cao, Zhiyong Lou, Ming Tan, Yutao Chen, Yijin Liu, Zhushan Zhang, Xuejun C. Zhang, Xi Jiang, Xuemei Li, and Zihe Rao. Structural basis for the recognition of blood group trisaccharides by norovirus. J Virol, 2007; 81: 5949-57.
Farkas, T., K. Sestak, C. Wei and X. Jiang. Characterization of a rhesus monkey calicivirus representing a new genus of caliciviridae. Journal of Virology, 2008; 82(11):5408-16.
Tan, M., M. Jin, H. P. Xie, Z. J. Duan, X. Jiang and Z. Y. Fang. Outbreak studies of a GII-3 and a GII-4 norovirus revealed an association between HBGA phenotypes and viral infection. Journal of Medical Virology, 2008; 80:1296-301.
Bu, W. M., A. Mamedova, M. Tan, M. Xia, X. Jiang and R. S. Hegde. Structural basis for the receptor binding specificity of the Norwalk virus. Journal of Virology, 2008; 82(11):5340-7.
Professional Organization Memberships
- American Society for Microbiology
- American Society for Virology
Books
Metcalf TG, Jiang X, Estes MK, Melnick JL. Nucleic acid probe and molecular hybridization for detection of virus in environmental samples. In Progress in Medical Virology (JL Melnick, ed). Karger, Basel. 1988; 35:186-214.
Estes MK, Jiang X, Zhou YJ, Metcalf TG. Nucleic acid hybridization to detect enteric viruses. In Biotechnology and Food Safety. Butterworth - Heinemann, Boston, 1990; 186-91.
Jiang X, Estes MK. Detection of human calicivirus in stools by RT-PCR. In PCR: Protocols for Diagnosis of Human and Animal Virus Diseases. Becker/Darai (Eds.) Springer-Verlag, Heidelberg, 1998.
Jiang X, Matson DO. Detection of human caliciviruses and astroviruses in stools by RT-PCR, -A diagnostic virology protocol. In Methods in Molecular Biology. Warnes/Stephenson (Eds.) Humana Press Inc., 1999.
Jiang X. Pickering LK. Update of caliciviruses and human acute gastroenteritis. Concise Reviews of Pediatric Infectious Diseases.Concise Reviews of Pediatric Infectious Diseases, p1069-1070, Nov. 2002.
Jiang X. Development of serological and molecular tests for the diagnosis of calicivirus infection. In Elsevier Book series Perspectives in Medical Virology, U. Desselberger and J. Gray, eds. p491-508, 2002.
Patents
- US Patent "Methods and Reagents to Detect and Characterize Norwalk and Related Viruses". Inventers: Mary K. Estes, Xi Jiang, David O. Matson, and David Y. Graham. Patent Date: September 24, 1996. United States Patent No.: 5,559,014.
- US Patent: "Method, composition and kit for antigenic binding of Norwalk-like viruses". Inventers: Xi Jiang and Jacques LePendu, published on January 1, 2004.
Related Areas
This person works in these other areas at Cincinnati Children's Hospital Medical Center:
