Molecular Cardiovascular Biology

James Gulick, MS

Title

Instructor, Molecular Cardiovascular Biology

Appointment

Instructor, University of Cincinnati College of Medicine

Email

james.gulick@cchmc.org

Phone

513-803-0994

Fax

513-636-5958

Credentials

MS: University of Missouri-Columbia, Columbia, Mo, 1983

Position History

1998- Research Health and Safety Committee

2002- Location S Research Building Committee (lab design)

2006- Institutional Biosafety Committee

Research

Understanding how certain mutations in contractile protein genes are able to alter the function of the heart

Publications, Most Recent

Sadayappan, S, Klevitsky, R, Lorenz, JN, Sargent, M, Gulick, J, Molkentin, J, Robbins, J (2009) Cardiac myosin binding protein C phosphorylation in the mouse heart. Circulation (in press)

Lowey, S, Lesko, LM, Rovner, AS, Hodges, AR, White, SL, Low, RB, Rincon, M, Gulick, J, Robbins, J (2008) Functional effects of the hypertrophic cardiomyopathy R403Q mutation are different in an alpha- or beta-myosin heavy chain backbone. J. Biol. Chem. 283: 20579-20589

Krenz, M, Gulick, J, Osinska, HE, Colbert, MC, Molkentin, JD, Robbins, J (2008) Role of ERK1/2 signaling in congenital valve malformations in Noonan syndrome.Proc. Natl. Acad. Sci. USA 105: 18930-18935

Pattison, JS., Waggoner, J. R., James, J., Martin, L., Gulick, J., Osinska, H., Klevitsky, R., Kranias, E. G., Robbins, J. (2008) Phospholamban overexpression in transgenic rabbits. Transgenic Res 17: 157-170

Maloyan, A., Gulick, J., Glabe, C. G., Kayed, R., Robbins, J. (2007) Exercise reverses pre-amyloid oligomer and prolongs survival in ÿB-crystallin-based desmin related cardiomyopathy. Proc. Natl. Acad. Sci. USA 104: 5995-6000

Tallini YN, Ohkura M, Choi BR, Ji G, Imoto K, Doran R, Lee J, Plan P, Wilson J, Xin HB, Sanbe A, Gulick J, Mathai J, Robbins J, Salama G, Nakai J, Kotlikoff MI (2006) Imaging cellular signals in the heart in vivo: Cardiac expression of the high-signal Ca2+ indicator GCaMP2.Proc Natl Acad Sci USA 103, 4753-4758