Molecular Cardiovascular Biology

Stephanie M. Ware, MD, PhD

Appointment

Assistant Professor

Email

stephanie.ware@cchmc.org

Phone

Office: (513) 636-9427Lab: (513) 636-2531

Fax

(513) 636-5958

Office Location

R-3543Visit the Ware Lab

Credentials

MD: University of Cincinnati College of Medicine, Cincinnati, OH, 1997.

PhD: University of Cincinnati College of Medicine, Cincinnati, OH, 1995.

BS: Butler University, Indianapolis, IN, 1989.

Position History

1991-1995 Graduate Assistant, University of Cincinnati and Children's Hospital Medical Center, Cincinnati, OH.
Doctoral advisor: Jeffrey Robbins.
Thesis: In vivo regulation of the mouse β-myosin heavy chain gene.
1997-2000 Pediatric Resident, Baylor College of Medicine, Houston, TX
2000-2002 Clinical Postdoctoral Fellow in Genetics, Baylor College of Medicine, Houston, TX
2002-2004 Assistant Professor, Molecular and Human Genetics, Baylor College of Medicine, Houston, TX
2004-present Assistant Professor, Pediatrics, Division of Molecular Cardiovascular Biology, Cincinnati Children's Hospital Medical Center

Awards and Honors

1991 McGraw-Hill Scholastic Award (top two students in medical school class), University of Cincinnati College of Medicine
1991-1994 Marion-Merrill Dow Scholar, University of Cincinnati College of Medicine
1996 Alpha Omega Alpha, University of Cincinnati College of Medicine
1997-1989 Krucker Merit Scholarship, University of Cincinnati College of Medicine
2001 Travel Award Winner, Society for Inherited Metabolic Disorders
2000-2002 Vivian L. Smith Foundation Fellow in Genetics, Baylor College of Medicine
2003 Weinstein Cardiovascular Development Conference, Young Investigator Award
2005 Pediatric Academic Societies' Young Investigator's Travel Award
2005 Society for Pediatric Research Richard D. Rowe Award in Perinatal Cardiology, Honorable Mention Research
2006 Society for Pediatric Research, elected member

Research

For details of research in the Ware Lab please visit the Ware Lab web site.

Research Grants and Contracts

Current Support

NIH RO1 HL088639 - PI: Stephanie Ware, MD, PhD 4/1/2007-3/31/2012. Role of the embryonic node in cardiac development and congenital heart disease.

Trustee Award, Cincinnati Children's Hospital Medical Center - PI: Stephanie Ware, MD, PhD 7/1/07-6/30/09. Control of Morphogenetic Movements during Gastrulation.

March of Dimes Research Foundation 5-FY2007-1142 - PI: Stephanie Ware, MD, PhD 6/1/07-5/31/10. Left right patterning defects and cardiac morphogenesis. (declined due to overlap)

Trainee Support

American Heart Association AHA 0725539B - PI: James Bedard; Sponsor: Stephanie Ware, MD, PhD 7/1/07-6/30/09. Genetic and Molecular Roles of a Novel ZIC3 Isoform in Cardiovascular Development. Postdoctoral fellowship, Great Rivers Affiliate

American Heart Association AHA 0725562B - PI: Shuyun Wang; Sponsor: Stephanie Ware, MD, PhD 7/1/07-6/30/09. Determination of Cardiac Looping: Role of Zic3 at the node. Postdoctoral fellowship, Great Rivers Affiliate

Publications, Most Recent

Purandare, S. *, Ware, S.M. *, Kwan KM, Gebbia, M, Bassi MT, Deng JM, Vogel, H, Behringer RR, Belmont JW, Casey B. A complex syndrome of left right axis, central nervous system and axial skeleton defects in Zic3 mutant mice.Development 129: 2293-2302, 2002

Ware SM and Belmont JW. ZIC3, CFC1, ACVR2B and EBAF and the Visceral Heterotaxies. In Epstein C, Erickson RP and Wynshaw-Boris A eds, Molecular Basis of Inborn Errors of Development (Oxford University Press), 2004.

Ware SM, Peng J, Zhu L, Fernbach S, Colicos S, Casey B, Towbin J, Belmont JW. Identification and functional analysis of ZIC3 mutations in heterotaxy and related congenital heart defects.American Journal of Human Genetics 74: 93-105, 2004.

Elefteriou F, Takeda S, Ebihara, K, Magre J,Patano N, Ae Kim C, Ogawa Y, Liu X, Ware SM, Craigen WJ, Robert JJ, Vinson, C, Nakao K, Capeau J, Karsenty G. Serum leptin level is a regulator of bone mass.Proceedings of the National Academy of Sciences of the United States of America 101: 3258-3263, 2004.

Belmont JW, Mohapatra B, Towbin JA, Ware, SM. Molecular genetics of heterotaxy syndromes.Current Opinion in Cardiology 19(3): 216-20, 2004.

Scaglia F, Towbin JA, Craigen WJ, Belmont JW, Smith EO, Neish SR, Ware SM, Bowles KR, Hunter J, Fernbach SD, Vladutiu G, Wong L-JC, Vogel H. Clinical Spectrum, Morbidity, and Mortality in 113 Pediatric Patients with Mitochondrial Disease.Pediatrics 114: 925-931, 2004.

Jeffries JL, Belmont JW, Craigen WJ, Ware SM, Fernbach SD, Neish SR, O'Brien Smith E, Towbin JA. Genetic Predictors and Reverse Remodeling of Dilated Cardiomyopathy in Muscular Dystrophy.Circulation 112: 2799-2804, 2005.

Zhu, L, Belmont JW, Ware SM. Genetics of Human Heterotaxias.European Journal of Human Genetics 14: 17-25, 2006.

Chen, C*, Ware, SM*, Sato A, Houston-Hawkins, DE, Habas, R, Matzuk, MM, Shen, MM, Brown, CW. The Vg1-related protein GDF3 acts in a Nodal signaling pathway in the pre-gastrulation mouse embryo.Development 133: 319-329, 2006. *co-first authors.

Ware, SM, Harutyunyan, KG, Belmont, JW. Zic3 is critical for early embryonic patterning during gastrulation.Developmental Dynamics 235: 776-785, 2006.

Ware, SM, Harutyunyan, KG, Belmont, JW. Heart defects in X linked heterotaxy: evidence for a genetic interaction of Zic3 with the Nodal signaling pathway.Developmental Dynamics 235:1631-1637, 2006.

Ware, SM. DNA mutation analysis in heterotaxy.Methods Mol Med 126:247-56, 2006.

Bedard, JEJ, Purnell, JD, Ware, SM. Nuclear import and export signals are essential for proper cellular trafficking and function of ZIC3.Human Molecular Genetics 16: 187-198, 2007.

Professional Organization Memberships

Fellow of the American Academy of Pediatrics
American Society of Human Genetics
Certification by the American Board of Pediatrics (2000-2007)
Diplomate of the American Board of Medical Genetics in Clinical Genetics (2002-2012)