Molecular Cardiovascular Biology

John W. Elrod, PhD

Title

Research Fellow, Division of Molecular Cardiovascular Biology

Email

john.elrod@cchmc.org

Phone

513-636-4809

Fax

513-636-5958

Credentials

PhD: Albert Einstein College of Medicine, Yeshiva University, Bronx, NY, 2007

Research

Myocardial infarction; heart failure; cell death; ischemia-reperfusion injury; diabetes

Research Grants and Contracts

URC Postdoctoral Fellow Research Grant. 2008.

F32 Individual Fellowship, HL092737. PI: John Elrod, “Defining the Role of Necrotic Cell Death in the Progression of Heart Failure”. 2008.

F32 Training Fellowship, HL07382-31. PI: Arnold Schwartz, “Training in Cardiovascular Biology”. 2007.

Publications, Most Recent

Elrod JW, Calvert JW, Gundewar S, Bryan NS, Lefer DJ. Cardiac Derived Nitric Oxide Promotes Distant Organ Protection: Evidence for an Endocrine Role of Nitrite.Proc Natl Acad Sci. 2008 Aug 12;105(32):11430-5.

Elrod JW, Harrell M, Flagg TP, Gundewar S, Magnuson MA, Nichols CG, Coetzee WA, Lefer DJ. Role of sulfonylurea receptor type 1 subunits of ATP-sensitive potassium channels in myocardial ischemia/reperfusion injury.Circulation. 2008 Mar 18;117(11):1405-13.

Elrod JW, Calvert JW, Morrison J, Doeller JE, Kraus DW, Tao L, Scalia R, Kiss L, Szabo C, Kimura H, Chow C, Lefer DJ. Hydrogen Sulfide Attenuates Myocardial Ischemia-Reperfusion Injury via Preservation of Mitochondrial Function. Proc Natl Acad Sci. 2007 Sep 25;104(39):15560-5.

Bryan NS, Calvert JW, Elrod JW, Gundewar S, Lefer DJ. Dietary nitrite supplementation protects against myocardial ischemia-reperfusion injury. Proc Natl Acad Sci. 2007 Nov 27;104(48):19144-9.

Elrod JW, Greer JJ, Lefer DJ. Sildenafil Mediated Acute Cardioprotection is Independent of the NO/cGMP Pathway. Am J Physiol Heart Circ Physiol. 2007 Jan;292(1):H342-7.

Elrod JW, Duranski MR, Langston W, Greer JJ, Tao L, Dugas TR, Kevil CG, Champion HC, Lefer DJ. eNOS gene therapy exacerbates hepatic ischemia-reperfusion injury in diabetes: a role for eNOS uncoupling. Circ Res. 2006 Jul 7;99(1):78-85.

Elrod JW, Greer JJ, Bryan NS, Langston W, Szot JF, Gebregzlabher H, Janssens S, Feelisch M, Lefer DJ. Cardiomyocyte-specific overexpression of NO synthase-3 protects against myocardial ischemia-reperfusion injury. Arterioscler Thromb Vasc Biol. 2006 Jul;26(7):1517-23.

Presentations, Most Recent

Hydrogen Sulfide Donor Protects Against Acute Myocardial Ischemia-Reperfusion Injury. AHA Scientific Sessions, Nov. 14, 2006.

SUR1 Knockout Mice are Protected Against Myocardial Ischemia-Reperfusion Injury. AHA Scientific Sessions, Nov. 15, 2006.

Genetic Ablation of bak Protects Against Myocardial Ischemia-Reperfusion Injury. AHA Scientific Sessions, Nov. 13, 2006.

Protection Against Myocardial Reperfusion Injury by Selective Inhibition of PDE-5 is Lost in the Setting of Diabetes. AHA Scientific Sessions. Nov. 15, 2005.

Genetic Ablation of Caveolin-1 Protects Against Ischemia-Reperfusion Injury. AHA Scientific Sessions. Nov. 14, 2005.

Cardiomyocyte-Restricted Overexpression of the Human eNOS Gene Significantly Attenuates Myocardial Ischemia Reperfusion Injury. AHA Scientific Sessions. Nov. 14, 2005.

Cardiomyocyte-specific overexpression of eNOS attenuates myocardial ischemia reperfusion injury. Experimental Biology. April 2, 2005.