Molecular Cardiovascular Biology

Jeffrey Robbins, PhD

Appointment

Professor of Pediatrics; Adjunct Appointment: Professor of Molecular Physiology

Bio

Jeff Robbins CV (.pdf)

Research

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My laboratory has established the means to direct the heart to synthesize normal and mutant proteins. We can turn these on and off at will. This allows us to establish cause-and-effect relationships between these mutant proteins and the development of cardiac disease.

To understand these relationships, and to establish models in which the pathogenic processes can be studied longitudinally, we have created genetically modified mice and rabbits that synthesize the mutant proteins. Subsequently, one can determine whether or not the protein's presence causes the effects directly or indirectly. The goal is to define potential therapeutic targets.

By affecting the heart's protein complement in a defined manner, one has the means to establish both mechanism and the function of the different mutated proteins. By directing expression of an engineered protein to the heart, one is now able to effectively remodel the cardiac protein profile and study the consequences of a single genetic manipulation at the molecular, biochemical, cytological and physiologic levels.

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Research We are currently conducting research in these areas:

Education A number of graduate students and postdocs find educational opportunities in the Lab. Learn more.

Facilities Researchers in the Robbins Lab have access to extensive research facilities, including lab space, equipment, and core services. Learn more.

Meet the Lab More than two dozen talented scientists conduct cutting-edge research in the Lab. Come meet them.