Jeanne James, MD
Research Assistant Professor
Contact Dr. James
Jeanne James, MD
Research Assistant Professor
jeanne.james@cchmc.org
Phone: 513-636-2530
Fax: 513-636-5958Research Image
Research Description
As a pediatric cardiologist, I am interested in exploring the mechanisms that lead to altered heart function and the compensatory phenomena intrinsic to the myocardium.
Acquired heart disease of adulthood differs fundamentally from heart disease in infants and children, where alterations in cardiac pump function are frequently due to increased hemodynamic loads imposed by congenital cardiac malformations. While heart surgery is effectively curative in some congenital defects, in others surgery is a palliative procedure that leaves the patient with residual circulation abnormalities.
I study the progression of heart disease in mice and rabbits to understand the intermediate steps between cardiac compensation and overt heart failure. By defining the critical events in this cascade and determining where effective interventions can be made, the treatment of heart failure will hopefully be more successful, enabling children with residual cardiac dysfunction to enjoy more active lives.
Publications
- James J, Martin L, Krenz M, Quatman C, Jones F, Klevitsky R, Gulick J, Robbins J. (2005) Forced expression of alpha-myosin heavy chain in the rabbit ventricle results in cardioprotection under cardiomyopathic conditions. Circulation 111:2339-46.
- Sanbe A, James J, Tuzcu V, Nas S, Martin L, Gulick J, Osinska H, Sakthivel S, Klevitsky R, Ginsburg KS, Bers DM, Zinman B, Lakatta EG, Robbins J. (2005) Transgenic rabbit model for human troponin I-based hypertrophic cardiomyopathy. Circulation 111:2330-8.
- James J, Zhang Y, Wright K, Witt S, Glascock E, Osinska H, Klevitsky R, Martin L, Yager K, Sanbe A, Robbins J. (2002) Transgenic rabbits expressing mutant essential light chain do not develop hypertrophic cardiomyopathy. J Mol Cell Cardiol 34:873-82.
- James J, Zhang Y, Osinska H, Sanbe A, Klevitsky R, Hewett TE, and Robbins J. (2000) Transgenic modeling of a cardiac troponin I mutation linked to familial hypertrophic cardiomyopathy. Circ Res. 87:805-811.
- James J, Sanbe A, Yager K, Martin L, Klevitsky H, and Robbins J. Genetic manipulation of the rabbit heart via transgenesis. (2000) Circulation 101:1715-21.
- James JM, Osinska H, Hewett TE, Kimball T, Klevitsky R, Witt S, Hall DG, Gulick J, and Robbins J. (1999) Transgenic overexpression of a motor protein at high levels results in severe cardiac pathology. Transgenic Res. 8:9-22.
- James J, Hewett TE, and Robbins J. (1998) Cardiac physiology in transgenic mice. Circ Res. 82:407-415.
