Jeffery D. Molkentin, PhD, Professor
Contact Dr. Molkentin
Jeffery D. Molkentin, PhD
Professor, Howard Hughes Medical Institute
Cincinnati Children's Hospital Medical Center
Molecular Cardiovascular Biology
240 Albert Sabin Way; MLC7020
Cincinnati, OH 45229-3039
Telephone 513-636-3557
Email jeff.molkentin@cchmc.org Foundation Funding for Research Activities
The Molkentin Lab Members
Research Overview
The laboratory is interested in understanding the intracellular signaling pathways and transcriptional regulatory circuits that control mammalian cell growth and differentiation. In response to various growth factors or stress stimuli, discrete signal transduction pathways are activated at the cell membrane and within the cytoplasm that subsequently modify the activity of key transcription factors resulting in the reprogramming of gene expression. Important model systems for the investigation of growth and stress responses include cardiac myocytes, skeletal muscle myocytes, and T lymphocytes. The laboratory is specifically interested in characterizing signal transduction through the calcium-activated phosphatase calcineurin and the downstream transcriptional effector protein NFAT. Calcineurin directly dephosphorylates NFAT transcription factors allowing their nuclear import as a mechanism of inducible gene regulation in cardiac and skeletal muscle cells and T cells. We are also interested in mitogen-activated protein kinase (MAPK) signaling pathways and their role in altering gene expression in mammalian cells. The laboratory uses transgenic mouse models and gene knock-out technology towards dissecting intracellular signaling pathways and transcriptional regulatory factors, as well as routine molecular approaches.
Research Interests
Learn more about our multiple interest areas, including the following:
Learn more about research tools from our laboratory, now available through Seven Hills Bioreagents, a venture of Cincinnati Children's Research Foundation.
You may also learn more about Jeff Molkentin at his biographical sketch page.
Contact Us
The Molkentin Laboratory is part of the Division of Molecular Cardiovascular Biology at Cincinnati Children's Research Foundation. The lab is located in Location R (Research Foundation Building), Room 3030.
Jeffery D. Molkentin, PhD
Professor, Howard Hughes Medical Institute
Cincinnati Children's Hospital Medical Center
240 Albert Sabin Way; MLC7020
Cincinnati, OH 45229-3039
Telephone: 513-636-3557
Email: jeff.molkentin@cchmc.org
