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Molkentin Lab

Jeffery D. Molkentin, PhD, Professor

Contact Dr. Molkentin

Jeffrey Molkentin is a faculty member in the Division of Molecular Cardiovascular Biology at Cincinnati Children's
Jeffery D. Molkentin, PhD
Professor, Howard Hughes Medical Institute
Cincinnati Children's Hospital Medical Center
Molecular Cardiovascular Biology

 

240 Albert Sabin Way; MLC7020
Cincinnati, OH 45229-3039
Telephone 513-636-3557
Email jeff.molkentin@cchmc.org

Foundation Funding for Research Activities

HHMI logo
http://www.hhmi.org
Leducq Foundation Logo
http://www.foundationleducq.org
Jain Foundation Logo
http://www.jain-foundation.org

The Molkentin Lab Members

Molkentin Lab 2009
PI
Jeff Molkentin jeff.molkentin@cchmc.org
Faculty
Angela Lorts angela.lorts@cchmc.org
Hiroyuki Nakayama 
hiroyuki.nakayama@cchmc.org
Technicians
N. Scott Blair nscott.blair@cchmc.org
Zeenat Jamal zeenat.jamal@cchmc.org
Michelle Sargent michelle.sargent@cchmc.org
Jennifer Schwanekamp jennifer.schwanekamp@cchmc.org
Allen York allen.york@cchmc.org
Aryn Schloemer 
aryn.schloemer@cchmc.org
Research Fellows
Federica Accornero federica.accornero@cchmc.org
Mannix Auger-Messier mannix.auger-messier@cchmc.org
R. Nathan Correll rnathan.correll@cchmc.org
Jennifer Davis jennifer.davis@cchmc.org
Petra Eder petra.eder@cchmc.org
John Elrod john.elrod@cchmc.org
Sanjeewa Goonasekera sanjeewa.goonasekera@cchmc.org
Izhak Kehat izhak.kehat@cchmc.org
Jennifer Kwong jennifer.kwong@cchmc.org
Qinghang Liu qinghang.liu@cchmc.org
Jeffrey M. Lynch jeffreyM.lynch@cchmc.org
Marjorie Maillet marjorie.maillet@cchmc.org
Doug Millay doug.millay@cchmc.org
Jop van Berlo jop.vanberlo@cchmc.org
Xu Wu xu.wu@cchmc.org
Students
Matthew Benard benardmj@email.uc.edu
Erin Wissing erin.wissing@cchmc.org
Jason Karch jason.karch@cchmc.org
Former members
Christopher Baines bainesc@missouri.edu
Julian Braz julian.braz@roche.com
Orlando Bueno OBueno@its.jnj.com
Yan-Shan Dai ydai@abraxisbio.com
Leon DeWindt dewindt@niob.knaw.nl
Michael Hambleton mike_hambleton@hotmail.com
Joerg Heineke Heineke.Joerg@mh-hannover.de
Rob Kaiser rkaiser14@gmail.com
Qiangrong Liang qliang@usd.edu
Toru Oka toka115@gmail.com
Stephanie Parsons steph_parsons735@hotmail.com
Nicole Purcell nhpetunia@yahoo.com
Bastiano Sanna bastiano.sanna@gmail.com
Jian Xu eeytaxu@gmail.com

Research Overview

The laboratory is interested in understanding the intracellular signaling pathways and transcriptional regulatory circuits that control mammalian cell growth and differentiation. In response to various growth factors or stress stimuli, discrete signal transduction pathways are activated at the cell membrane and within the cytoplasm that subsequently modify the activity of key transcription factors resulting in the reprogramming of gene expression. Important model systems for the investigation of growth and stress responses include cardiac myocytes, skeletal muscle myocytes, and T lymphocytes. The laboratory is specifically interested in characterizing signal transduction through the calcium-activated phosphatase calcineurin and the downstream transcriptional effector protein NFAT. Calcineurin directly dephosphorylates NFAT transcription factors allowing their nuclear import as a mechanism of inducible gene regulation in cardiac and skeletal muscle cells and T cells. We are also interested in mitogen-activated protein kinase (MAPK) signaling pathways and their role in altering gene expression in mammalian cells. The laboratory uses transgenic mouse models and gene knock-out technology towards dissecting intracellular signaling pathways and transcriptional regulatory factors, as well as routine molecular approaches.

Research Interests

Learn more about our multiple interest areas, including the following:

Learn more about research tools from our laboratory, now available through Seven Hills Bioreagents, a venture of Cincinnati Children's Research Foundation.

You may also learn more about Jeff Molkentin at his biographical sketch page.

Contact Us

The Molkentin Laboratory is part of the Division of Molecular Cardiovascular Biology at Cincinnati Children's Research Foundation. The lab is located in Location R (Research Foundation Building), Room 3030.

Jeffery D. Molkentin, PhD
Professor, Howard Hughes Medical Institute
Cincinnati Children's Hospital Medical Center
240 Albert Sabin Way; MLC7020
Cincinnati, OH 45229-3039
Telephone: 513-636-3557
Email: jeff.molkentin@cchmc.org