Regulation of Cardiac Development
The laboratory is also interested in understanding the early transcriptional regulatory code that specifies the cardiac myocyte cell lineage during embryonic development. Transcription factors such as Nkx2.5, GATA4, GATA6, TBX5, HAND1, HAND2, MEF2, and SRF are thought to generate a combinatorial code that directs the determination and differentiation of cardiac myocytes. Using genetic loss-of-function approaches in the mouse, the laboratory is attempting to dissect the critical components of this transcriptional code.
Contact Us
The Molkentin Laboratory is part of the Division of Molecular Cardiovascular Biology at Cincinnati Children's Research Foundation. The lab is located in Location R (Research Foundation Building), Room 3030.
Jeffery D. Molkentin PhD
Professor
Cincinnati Children's Hospital Medical Center
3333 Burnet Ave, MLC7020
Room 3030
Cincinnati, OH 45229-3039
Telephone: 513-636-3557
Email: jeff.molkentin@cchmc.org
