Regulation of T-lymphocyte Development
The laboratory is also interested in understanding the intracellular signaling pathways that mediate T-lymphocyte maturation and activation during antigen challenge. Specifically, the calcium-calmodulin-activated protein phosphatase calcineurin (PP2B) and its downstream transcriptional activator NFAT serve as important regulators of T-lymphocyte positive selection and activation following TCR stimulation. The lab is interested in understanding regulatory mechanisms in T lymphocytes in comparison with cardiac and skeletal muscle cells to enable the construction of a more comprehensive perspective on mammalian signaling circuitry in general.
Contact Us
The Molkentin Laboratory is part of the Division of Molecular Cardiovascular Biology at Cincinnati Children's Research Foundation. The lab is located in Location R (Research Foundation Building), Room 3030.
Jeffery D. Molkentin PhD
Professor
Cincinnati Children's Hospital Medical Center
3333 Burnet Ave, MLC7020
Room 3030
Cincinnati, OH 45229-3039
Telephone: 513-636-3557
Email: jeff.molkentin@cchmc.org
