Regulation of Transcription
The laboratory is also interested in defining basic mechanisms of gene expression regulation in mammalian cells through alterations in transcription factor potency as mediated by phosphorylation or by alterations in subcellular localization. Alternatively, transcription factors also participate in multi-protein complexes with each other as well as with basal regulators of transcription such as p300/CBP or histone deacetylases (HDACs). For example, the cardiac-expressed zinc finger-containing transcription factor GATA4 interacts with CBP/p300, as well as a large number of other cardiac-expressed transcription factors. An understanding of basic transcriptional regulatory mechanisms will shed additional light on the regulatory paradigms that underlie cellular differentiation and various disease states.
Contact Us
The Molkentin Laboratory is part of the Division of Molecular Cardiovascular Biology at Cincinnati Children's Research Foundation. The lab is located in Location R (Research Foundation Building), Room 3030.
Jeffery D. Molkentin PhD
Professor
Cincinnati Children's Hospital Medical Center
3333 Burnet Ave, MLC7020
Room 3030
Cincinnati, OH 45229-3039
Telephone: 513-636-3557
Email: jeff.molkentin@cchmc.org
