Regulation of Skeletal Muscle Development and Hypertrophy
We are also investigating the regulatory mechanisms that control skeletal muscle hypertrophy and fiber-type switching between the fast/glycolytic and the slow/oxidative programs. Specific signal transduction pathways are dedicated to the regulation of skeletal muscle hypertrophy, some of which are in common to the myocardium, while others are distinct. Specific signal transduction pathways also regulate the plasticity of skeletal muscle in its ability to adapt and switch between the fast and slow fiber-type programs. We are also attempting to understand the signaling pathways that underlie various disease processes associated with muscular dystrophy. Our studies of skeletal muscle mostly utilize tissue-specific gene targeting in the mouse, as well as skeletal muscle myoblast cultures in vitro.
Contact Us
The Molkentin Laboratory is part of the Division of Molecular Cardiovascular Biology at Cincinnati Children's Research Foundation. The lab is located in Location R (Research Foundation Building), Room 3030.
Jeffery D. Molkentin, PhD
Professor
Cincinnati Children's Hospital Medical Center
3333 Burnet Ave, MLC7020
Room 3030
Cincinnati, OH 45229-3039
Telephone: 513-636-3557
Email: jeff.molkentin@cchmc.org
