Trainees in the Robbins Lab
The laboratory trains at all levels: undergraduates, graduate students, post-doctoral fellows and clinicians who wish to apply their knowledge to basic research as well. Normally, the laboratory consists of a mix of these trainees, with post-doctoral fellows making up the majority of the 12- to 18-person lab.
A trainee will have the opportunity to make defined changes in the cardiovascular complement and then understand those changes at the molecular, biochemical, cellular, organ and whole animal levels. S/he will then have the opportunity to pursue the downstream targets responsible for those changes by carrying out interrogations of the total genome using in silico and bioinformatic approaches.
Sample Publications
Nakamura T, Colbert MC, Robbins J. (2006) Neural crest cells retain multipotential characteristics in the developing valves and label the cardiac conduction system. Circ Res.
Sadayappan S, Gulick J, Osinska H, Martin LA, Hahn HS, Dorn GW, 2nd, Klevitsky R, Seidman CE, Seidman JG, Robbins J. (2005) Cardiac myosin-binding protein-C phosphorylation and cardiac function. Circ Res 97:1156-63.
Sanbe A, Osinska H, Villa C, Gulick J, Klevitsky R, Glabe CG, Kayed R, Robbins J. (2005) Reversal of amyloid-induced heart disease in desmin-related cardiomyopathy. Proc Natl Acad Sci U S A 102:13592-7.
Maloyan A, Sanbe A, Osinska H, Westfall M, Robinson D, Imahashi K, Murphy E, Robbins J. (2005) Mitochondrial dysfunction and apoptosis underlie the pathogenic process in alpha-B-crystallin desmin-related cardiomyopathy. Circulation 112:3451-61.
Krenz M, Yutzey KE, Robbins J. (2005) Noonan syndrome mutation Q79R in Shp2 increases proliferation of valve primordia mesenchymal cells via extracellular signal-regulated kinase 1/2 signaling. Circ Res 97:813-20.
Sanbe A, James J, Tuzcu V, Nas S, Martin L, Gulick J, Osinska H, Sakthivel S, Klevitsky R, Ginsburg KS, Bers DM, Zinman B, Lakatta EG, Robbins J. (2005) Transgenic rabbit model for human troponin I-based hypertrophic cardiomyopathy. Circulation 111:2330-8.
James J, Martin L, Krenz M, Quatman C, Jones F, Klevitsky R, Gulick J, Robbins J. (2005) Forced expression of alpha-myosin heavy chain in the rabbit ventricle results in cardioprotection under cardiomyopathic conditions. Circulation 111:2339-46.
Learn more about training in the Robbins Lab
Jeffrey Robbins
Molecular Cardiovascular Biology
ML 7020
Children's Hospital
3333 Burnet Ave
Cincinnati, OH 45229-3039
jeff.robbins@cchmc.org
