Katherine Yutzey, PhD
Professor - Pediatrics Affiliated
Contact Dr. Yutzey
Division of Molecular Cardiovascular Biology
Cincinnati Children's Medical Center, ML7020
3333 Burnet Avenue
Cincinnati, OH 45229
Phone 513-636-8340
Fax 513-636-5958
Email yutzey@cchmc.org Research Description
The focus of our studies is the molecular regulation of embryonic heart development. Experimental embryological, genetic and molecular approaches are used for mechanistic analyses of early cardiac lineage determination and heart morphogenesis. We use both chick and mouse embryonic systems to identify critical regulatory interactions responsible for these events and to manipulate these interactions in vivo. In addition, several in vitro culture systems have been developed in which to examine the molecular regulatory events that control cardiac lineage determination and early heart chamber morphogenesis. Together these strategies are employed to establish the relationships between signaling pathways and transcription factors that control the specification of the cardiomyogenic lineage and heart chamber formation. These studies have potential clinical implications in efforts to convert multipotential stem cells to the cardiac lineage and in the diagnosis and treatment of congenital heart disease.
- Bushdid PB, Osinska H, Waclaw RR, Molkentin JD, Yutzey KE. (2003) NFATc3 and NFATc4 are required for cardiac development and mitochondrial function. Circ Res 92:1305-13.
- Yutzey KE, Benson DW. (2003) TBX5: a developmental key that fits many locks. J Mol Cell Cardiol 35:1175-7.
- Schulz RA, Yutzey KE. (2004) Calcineurin signaling and NFAT activation in cardiovascular and skeletal muscle development. Dev Biol 266:1-16.
- Lange AW, Molkentin JD, Yutzey KE. (2004) DSCR1 gene expression is dependent on NFATc1 during cardiac valve formation and colocalizes with anomalous organ development in trisomy 16 mice. Dev Biol 266:346-60.
- Liberatore CM, Yutzey KE. (2004) Calcineurin signaling in avian cardiovascular development. Dev Dyn 229:300-11.
- Lincoln J, Alfieri CM, Yutzey KE. (2004) Development of heart valve leaflets and supporting apparatus in chicken and mouse embryos. Dev Dyn 230:239-50.
- Plageman TF, Jr., Yutzey KE. (2004) Differential expression and function of Tbx5 and Tbx20 in cardiac development. J Biol Chem 279:19026-34.
- Parsons SA, Millay DP, Wilkins BJ, Bueno OF, Tsika GL, Neilson JR, Liberatore CM, Yutzey KE, Crabtree GR, Tsika RW, Molkentin JD. (2004) Genetic loss of calcineurin blocks mechanical overload-induced skeletal muscle fiber type switching but not hypertrophy. J Biol Chem 279:26192-200.
- Liberatore CM, Yutzey KE. (2004) MAP kinase activation in avian cardiovascular development. Dev Dyn 230:773-80.
- Plageman TF, Jr., Yutzey KE. (2005) T-box genes and heart development: putting the "T" in heart. Dev Dyn 232:11-20.
- Hinton RB Jr, Yutzey KE, Benson DW. (2005) Congenital heart disease: Genetic causes and developmental insights. Progress in Pediatric Cardiology 20:101-111.
- Lange AW, Rothermel BA, Yutzey KE. (2005) Restoration of DSCR1 to disomy in the trisomy 16 mouse model of Down syndrome does not correct cardiac or craniofacial development anomalies. Dev Dyn 233:954-63.
- Krenz M, Yutzey KE, Robbins J. (2005) Noonan syndrome mutation Q79R in Shp2 increases proliferation of valve primordia mesenchymal cells via extracellular signal-regulated kinase 1/2 signaling. Circ Res 97:813-20.
- Yutzey KE, Colbert M, Robbins J. (2005) Ras-related signaling pathways in valve development: ebb and flow. Physiology (Bethesda) 20:390-7.
- Clark KL, Yutzey KE, Benson DW. (2006) Transcription factors and congenital heart defects. Annu Rev Physiol 68:97-121.
- Lincoln J, Alfieri CM, Yutzey KE. (2006) BMP and FGF regulatory pathways control cell lineage diversification of heart valve precursor cells. Dev Biol 292:292-302.
- Lange AW, Yutzey KE. (2006) NFATc1 expression in the developing heart valves is responsive to the RANKL pathway and is required for endocardial expression of cathepsin K. Dev Biol 292:407-17.
- Lincoln J, Lange AW, Yutzey KE. (2006) Hearts and bones: shared regulatory mechanisms in heart valve, cartilage, tendon, and bone development. Dev Biol 294:292-302.
- Hinton RB, Jr., Lincoln J, Deutsch GH, Osinska H, Manning PB, Benson DW, Yutzey KE. (2006) Extracellular matrix remodeling and organization in developing and diseased aortic valves. Circ Res 98:1431-8.
- Plageman TF, Jr., Yutzey KE. (2006) Microarray analysis of Tbx5-induced genes expressed in the developing heart. Dev Dyn 235:2868-80.
- Karamboulas C, Dakubo GD, Liu J, De Repentigny Y, Yutzey K, Wallace VA, Kothary R, Skerjanc IS. (2006) Disruption of MEF2 activity in cardiomyoblasts inhibits cardiomyogenesis. J Cell Sci 119:4315-21.
- Lincoln J, Florer JB, Deutsch GH, Wenstrup RJ, Yutzey KE. (2006) ColVa1 and ColXIa1 are required for myocardial morphogenesis and heart valve development. Dev Dyn 235:3295-305.
- Shelton EL, Yutzey KE. (2007) Tbx20 regulation of endocardial cushion cell proliferation and extracellular matrix gene expression. Dev Biol 302:376-388.
- Yutzey KE, Robbins J. (2007) Principles of genetic murine models for cardiac disease. Circulation 115:792-9.
- Alfieri CM, Evans-Anderson HJ, Yutzey KE. (2007) Developmental regulation of the mouse IGF-I exon 1 promoter region by calcineurin activation of NFAT in skeletal muscle. Am J Physiol Cell Physiol 292:C1887-94.
- Lincoln J, Kist R, Scherer G, Yutzey KE. (2007) Sox9 is required for precursor cell expansion and extracellular matrix organization during mouse heart valve development. Dev Biol 305:120-32.
- Shelton EL, Yutzey KE. (2007) Heart development and T-box transcription factors: Lessons from avian embryos. Adv. Dev. Biol. 18:69-91.
- Evans-Anderson, H.J., C.M. Alfieri, and K.E. Yutzey (2008) Regulation of cardiomyocyte proliferation and myocardial growth during development by FOXO transcription factors. Circ. Res. 102:686-694.
- Shelton, E.L. and K.E. Yutzey. (2008) Twist1 function in endocardial cushion cell proliferation, migration and differentiation during heart valve development. Dev. Biol. 317: 282-295.
- Yutzey, K.E. (2008) Teed off: Cardiac conduction system development requires T-box transcription factors. Circ Res. 102:1295-1297 (invited editorial).
- Hinton, R.B., C.M. Alfieri, S.A. Witt, B.J. Glascock, P.R. Khoury, D.W. Benson, and K.E. Yutzey. (2008) Mouse heart valve structure and function: Echocardiographic and morphometric analyses from the fetus through the aged adult. Am. J. Physiol. Heart and Circ. Physiol. (In Press)
- Conlon F, Yutzey KE. (2007) T-box factors. In: Heart Development and Regeneration. Academic Press. N. Rosenthal and R. Harvey ed. (submitted).
Go to Katherine Yutzey's publications as listed by PubMed.
Research Grants and Awards
Current Support
2002-12 - NIH 1P01 HL069779-06 The Akt/FoxO pathway in heart development. K. Yutzey, component P.I. (25% effort); J. Robbins, PPG P.I. Total component direct costs $1,053,839
2004-08 - NIH 1P50 HL074728 Regulation of valvuloseptal development by DSCR1 K. Yutzey, component P.I. (20% effort); D.W. Benson, SCCOR P.I. Total component direct costs $1,135,000.
2006-10 - NIH 1R01 HL082716 Tbx20 regulation of heart valve development. K. Yutzey, P.I. (25% effort). Total direct costs $1,000,000.
Trainee Support
Member of training faculty for NIH training grants in Teratology, Cardiology, Pulmonary and Cardiovascular Biology, and Physiology at Children's Medical Center and The University of Cincinnati College of Medicine
2007-2008 American Heart Association-Great Rivers Affiliate, Pre-doctoral Fellowship
#0715360B The functions of Tbx20 and Twist1 in endocardial cushion development.
Elaine (Howells) Shelton, Fellow. K. Yutzey, Sponsor. Total direct costs $21,000.
2007-2009 American Heart Association-Great Rivers Affiliate, Pre-doctoral Fellowship
#0715107B NFATc1 regulation of extracellular matrix remodeling and cell proliferation in heart valve development.
Michelle Combs, Fellow. K. Yutzey, Sponsor. Total direct costs $42,000.
2007-2009 American Heart Association-Great Rivers Affiliate, Post-doctoral Fellowship
#0725321B Regulation of myocardial growth by FOXO transcription factors.
Heather Evans-Anderson, Fellow. K. Yutzey, Sponsor. Total direct costs $86,000.
Professional Experience
1992 - 1995 Post-doctoral Research Associate, Cornell University Medical College, New York, NY. Mentor: David Bader
1995 - 2002 Assistant Professor, Pediatrics-Affiliated, Division of Molecular Cardiovascular Biology, Cincinnati Children's Hospital Medical Center
2002 - 2007 Associate Professor, Pediatrics-Affiliated, Division of Molecular Cardiovascular Biology, Cincinnati Children's Hospital Medical Center
2007 - Present Professor, Pediatrics-Affiliated, Division of Molecular Cardiovascular Biology, Cincinnati Children's Hospital Medical Center
2004 - Present Director, Molecular and Developmental Biology Graduate Program, Cincinnati Children's Hospital Medical Center
National Memberships and Honors
- 1996-98 Trustee Grant Award, Children's Hospital Research Foundation
- 1998-99 Fifth Third Bank/Charlotte R. Schmidlapp Award
- 2001-2004 Established Investigator, American Heart Association
- 2002-2003 Co-Chair, Basic Cell and Molecular Biology-2 Peer Review Committee: American Heart Association-National
- 2002 Ad Hoc Peer Review: Cardiovascular B Special Emphasis Panel NIH
- 2002 Member Tissue Engineering Special Emphasis Panel NIH/NHLBI
- 2002-present Developmental Dynamics Editorial Board
- 2003 Program Project Grant Special Emphasis Panels (2) NIH/NHLBI
- 2003 Ad Hoc Peer Review: Cell Development and Function 5 (CDF-5) NIH
- 2003-present AHA Basic Research Council, Ohio/Virginia/Florida Affiliate
- 2004 Chair, American Heart Association, Basic-2 Peer Review Committee
- 2004-2005 Ad Hoc Peer Review: Cardiovascular Diff'n and Development (CDD) NIH
- 2005 AHA-National Science Classification Task Force
- 2005-present Stem Cells, Editorial Board
- 2005-present Weinstein Conference on Cardiovascular Development, Organizing Committee
- 2006-2010 Member, Program Project Review Parent Committee NIH/NHLBI
- 2007-present Developmental Biology, Editorial Board
- 2008-present Fellow of the Graduate School, University of Cincinnati
