Molecular Immunology

Edith Janssen, PhD

Appointment

Assistant Professor

Email

edith.janssen@cchmc.org

Phone

513-803-1055

Fax

513-636-5355

Credentials

MS: Utrecht University, The Netherlands, in Biology; 1995

Ph.D: Utrecht University, The Netherlands, in Immunology/Pharmacology; 1999

Awards and Honors

Career development Award, Leukemia and Lymphoma Society; 2004
Mucosal Immunology Fellowship (NOW); 1998
Erasmus Award for Excellence in Research; 1995
Erasmus Scholarship for Exchange Students; 1994

Publications, Most Recent

E.M. Janssen, N.M. Droin, E.E. Lemmens, M.J. Pinkoski, S.J. Bensinger, T.S. Griffith, D.R. Green, S.P. Schoenberger. T help controls CD8+ T cell memory through regulation of TRAIL-mediated AICD.Nature 2005 434:88-92.

J.A. Encinas, E.M. Janssen, D.B. Weiner, S.A. Calarota, D. Nieto, T. Moll, D.J. Carlo, R.B. Moss. Anti-T-cell Ig and mucin domain-containing protein 1 antibody decreases T(H)2 airway inflammation in a mouse model of asthma.J Allergy Clin Immunol. 2005 116:1343-1349.

R. Barouch-Bentov, E.E. Lemmens, J. Hu, E.M. Janssen, N.M. Droin, J. Song, S.P. Schoenberger, A. Altman. Protein kinase C-theta is an early survival factor required for differentiation of effector CD8+ T cells.J Immunol. 2005 175:5126-34.

K. Tabeta, K. Hoebe, E.M. Janssen, X. Du, P. Georgel, K. Crozat, S. Mudd, N. Mann, S. Sovath, J. Goode, L. Shamel, A.A. Herskovits, D.A. Portnoy, M. Cooke, L.M. Tarantino, T. Wiltshire, B.E. Steinberg, S. Grinstein, B. Beutler. 3d, a missense mutation that disrupts exogenous antigen presentation and signaling via Toll-like receptors 3, 7, and 9.Nature Immunology 2006 7;156-164.

K. Hoebe, Z. Jiang, P. Georgel, K. Tabeta, E. Janssen, X. Du, B. Beutler. TLR signaling pathways: opportunities for activation and blockade in persuit of therapy.Curr Pharm Des. 2006 12:4123-34.

E. Janssen, K. Tabeta, M. Barnes, S. McBride, S. Schoenberger, A.N. Theofilopoulos, B. Beutler, K. Hoebe. A cell-death induced TIR-independent pathway drives efficient T cell activation.Immunity 2006 24:787-799.

S.P. Schoenberger and E.M. Janssen. IL-2 gets with the Program.Nature Immunology 2006 7;798-800.

S. McBride, K. Hoebe, P. Georgel, E. Janssen, Cell-associated double-stranded RNA enhances anti-tumor activity through the production of Type I IFN.J. Immunol. 2006 177:6122-6218.

E. Gallagher, T. Enzler, A. Matsuzawa, A. Anzelon-Mills, D. Otero, R. Holzer, E. Janssen, M. Gao, M. Karin. Kinase MEKK1 is required for CD40-dependent activation of the kinases Jnk and p38, germinal center formation, B cell proliferation and antibody production.Nature Immunology 2006 8:57-63.

P. Georgel, Z. Jiang, S. Kunz, E. Janssen, J. Mols, K. Hoebe, S. Bahram, M.B.A. Oldstone, B. Beutler. Vesicular Stomatitis Virus Glycoprotein G activates a specific antiviral Toll-like Receptor 4-dependent pathway.Virology 2007 362:304-313.

K. Crozat, K. Hoebe, S. Ugolini, N.A. Hong, E. Janssen, S. Rutschmann, S. Mudd, S. Sovath, E. Vivier, B. Beutler. Jinx, an MCMV susceptibility phenotype caused by disruption of Unc13d: a mouse model of type 3 familial hemophagocytic lymphohistiocytosis.J. Exp. Med 2007 204:853-863.

B. Mothé, B. Stewart, C. Oseroff, H. Bui, S. Stogiera, Z. Garcia, C. Dow, M. Rodriguez-Carreno, M. Kotturi, V. Pasquetto, J. Botten, S. Crotty, E. Janssen, M. Buchmeier, and A. Sette. Chronic LCMV infection actively down regulates CD4+ T-cell responses directed against a broad range of epitopes.J. Immunol. 2007 179:1058-1067.

C.A Benedict, E.M. Janssen. Immunesuppression, learning from the masters.ERCI 2007, 3:659-662

C.A Benedict, A. Loewendorf, Z.Garcia, B.R. Blazar, E.M. Janssen. Dendritic cell programming by cytomegalovirus stunts naïve T cell responses via the PD-L1/PD-1 pathway. J.Immunol. 2008 180:4836-4847