Edith Janssen, PhD
Appointment
Assistant Professor
Email
edith.janssen@cchmc.org
Phone
513-803-1055
Fax
513-636-5355
Credentials
MS: Utrecht University, The Netherlands, in Biology; 1995
PhD: Utrecht University, The Netherlands, in Immunology/Pharmacology; 1999
Awards and Honors
- Career development Award, Leukemia and Lymphoma Society; 2004
- Mucosal Immunology Fellowship (NOW); 1998
- Erasmus Award for Excellence in Research; 1995
- Erasmus Scholarship for Exchange Students; 1994
Publications, Most Recent
E. Gallagher, T. Enzler, A. Matsuzawa, A. Anzelon-Mills, D. Otero, R. Holzer, E. Janssen, M. Gao, M. Karin. Kinase MEKK1 is required for CD40-dependent activation of the kinases Jnk and p38, germinal center formation, B cell proliferation and antibody production.Nature Immunology 2006 8:57-63.
E. Janssen, K. Tabeta, M. Barnes, S. McBride, S. Schoenberger, A.N. Theofilopoulos, B. Beutler, K. Hoebe. A cell-death induced TIR-independent pathway drives efficient T cell activation.Immunity 2006 24:787-799.
K. Hoebe, Z. Jiang, P. Georgel, K. Tabeta, E. Janssen, X. Du, B. Beutler. TLR signaling pathways: opportunities for activation and blockade in persuit of therapy.Curr Pharm Des. 2006 12:4123-34.
K. Tabeta, K. Hoebe, E.M. Janssen, X. Du, P. Georgel, K. Crozat, S. Mudd, N. Mann, S. Sovath, J. Goode, L. Shamel, A.A. Herskovits, D.A. Portnoy, M. Cooke, L.M. Tarantino, T. Wiltshire, B.E. Steinberg, S. Grinstein, B. Beutler. 3d, a missense mutation that disrupts exogenous antigen presentation and signaling via Toll-like receptors 3, 7, and 9.Nature Immunology 2006 7;156-164.
S. McBride, K. Hoebe, P. Georgel, E. Janssen, Cell-associated double-stranded RNA enhances anti-tumor activity through the production of Type I IFN.J. Immunol. 2006 177:6122-6218.
S.P. Schoenberger and E.M. Janssen. IL-2 gets with the Program.Nature Immunology 2006 7;798-800.
B. Mothé, B. Stewart, C. Oseroff, H. Bui, S. Stogiera, Z. Garcia, C. Dow, M. Rodriguez-Carreno, M. Kotturi, V. Pasquetto, J. Botten, S. Crotty, E. Janssen, M. Buchmeier, and A. Sette. Chronic LCMV infection actively down regulates CD4+ T-cell responses directed against a broad range of epitopes.J. Immunol. 2007 179:1058-1067.
C.A Benedict, E.M. Janssen. Immunesuppression, learning from the masters.ERCI 2007, 3:659-662P.
Georgel, Z. Jiang, S. Kunz, E. Janssen, J. Mols, K. Hoebe, S. Bahram, M.B.A. Oldstone, B. Beutler. Vesicular Stomatitis Virus Glycoprotein G activates a specific antiviral Toll-like Receptor 4-dependent pathway.Virology 2007 362:304-313.
K. Crozat, K. Hoebe, S. Ugolini, N.A. Hong, E. Janssen, S. Rutschmann, S. Mudd, S. Sovath, E. Vivier, B. Beutler. Jinx, an MCMV susceptibility phenotype caused by disruption of Unc13d: a mouse model of type 3 familial hemophagocytic lymphohistiocytosis.J. Exp. Med 2007 204:853-863.
C.A Benedict, A. Loewendorf, Z.Garcia, B.R. Blazar, E.M. Janssen. Dendritic cell programming by cytomegalovirus stunts naïve T cell responses via the PD-L1/PD-1 pathway. J.Immunol. 2008 180:4836-4847
Hildeman D, Janssen E. IFN-gamma and self-absorbed CD4+ T cells: a regulatory double negative. Nat Immunol. 2008 Nov;9(11):1210-2.]
Kim-Saijo M, Janssen EM, Sugie K. CD4 cell-secreted, posttranslationally modified cytokine GIF suppresses Th2 responses by inhibiting the initiation of IL-4 production.Proc Natl Acad Sci U S A. 2008 Dec 9;105(49):19402-7.
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Krebs P, Barnes MJ, Lampe K, Whitley K, Bahjat KS, Beutler B, Janssen E, Hoebe K. NK-cell-mediated killing of target cells triggers robust antigen-specific T-cell-mediated and humoral responses. Blood. 2009 Jun 25;113(26):6593-602
Professional Organization Memberships
- NVVI (Dutch Immunology Society)
- AACR (American Association for Cancer Research)
- AAI (American Association of Immunologists)
