Overview
We are a small and happy group studying cytokine (i.e. interleukin-2) receptor signaling in human T cells, and we are especially focussing on the role of lipid rafts, specialized areas within the cell membrane, in this process.
Learning more about these aspects of T cells is likely to improve our understanding of many immunological processes including, but not limited to, transplant rejection, a clinical problem we are frequently facing.
Publications
Goebel J, Forrest K, Morford L, Roszman TL (2002) Differential Localization of IL-2- and -15 Receptor Chains in Membrane Rafts of Human T Cells. J Leukocyte Biol 72:199-206
Morford LA, Forrest K, Logan B, Overstreet LK, Goebel J, Brooks WH, Roszman TL (2002) The Calcium-Dependent Cysteine Protease, Calpain II, Colocalizes With Detergent-Insoluble Glycosphingolipid Rafts in Jurkat Cells. Biochem Biophys Res Communications 295:540-6
Goebel J, Forrest K, Flynn D, Rao R, Roszman TL (2002) Lipid rafts, MHC Molecules and Immune Regulation. Human Immunology 63:813-20
Jensen S, Jackson EC, Simpson L, Reddy S, Goebel J (2003) Tacrolimus-Based Immunosuppression with Steroid Withdrawal in Pediatric Kidney Transplantation - 4-Year Experience at a Moderate-Volume Center. Pediatr Transplantation 7:119-24
Trachtman H, Frank R, Mahan JD, Portman R, Restaino I, Matoo TK, Tou C, Klibaner M (2003) Clinical trial of extended-release felodipine in pediatric essential hypertension. Pediatr Nephrol 18:548-53 (listed as local center PI in appendix)
Forrest K, Logan B, Strange J, Roszman TL, Goebel J (2005) Daclizumab Therapy in Kidney Transplantation - Different Mechanisms of Action in- versus ex-vivo? Transplant Immunology 14 (1):43-7
Mitsnefes MM, Subat-Dezulovic M, Khoury PR, Goebel J, Strife CF (in press, American Journal of Transplantation) Increased Incidence of Anemia After Kidney Transplantation In Children: Does It Affect Graft Survival?
Contact Us
Jens Goebel, MD
Associate Professor of Pediatrics
Medical Director of Kidney Transplantation
Cincinnati Children's Hospital Medical Center
Nephrology and Hypertension, MLC 7022
3333 Burnet Ave.
Cincinnati, OH 45229-3039
Phone: 513-636-4531 | Fax: 513-636-7407
